Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs

Paul A. Wender; Yu Nakagawa; Katherine E. Near; Daryl Staveness

doi:10.1021/ol502491f

Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs

Organic Letters ◽

10.1021/ol502491f ◽

2014 ◽

Vol 16 (19) ◽

pp. 5136-5139 ◽

Cited By ~ 30

Author(s):

Paul A. Wender ◽

Yu Nakagawa ◽

Katherine E. Near ◽

Daryl Staveness

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Design Synthesis ◽

Kinase C

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Faculty Opinions recommendation of Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726341354.793517944 ◽

2016 ◽

Author(s):

Boris Matija Peterlin

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Design Synthesis ◽

Kinase C

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Design, synthesis, and structure–activity relationship of new isobenzofuranone ligands of protein kinase C

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.02.097 ◽

2004 ◽

Vol 14 (11) ◽

pp. 2963-2967 ◽

Cited By ~ 23

Author(s):

Yoshiyasu Baba ◽

Yosuke Ogoshi ◽

Go Hirai ◽

Takeshi Yanagisawa ◽

Kumiko Nagamatsu ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Kinase C ◽

Structure Activity ◽

Relationship Of

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Design, Synthesis, and Structure—Activity Relationship of New Isobenzofuranone Ligands of Protein Kinase C.

ChemInform ◽

10.1002/chin.200438115 ◽

2004 ◽

Vol 35 (38) ◽

Author(s):

Yoshiyasu Baba ◽

Yosuke Ogoshi ◽

Go Hirai ◽

Takeshi Yanagisawa ◽

Kumiko Nagamatsu ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Kinase C ◽

Structure Activity ◽

Relationship Of

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Design, Synthesis, and Biological Activity of Isophthalic Acid Derivatives Targeted to the C1 Domain of Protein Kinase C

Journal of Medicinal Chemistry ◽

10.1021/jm900229p ◽

2009 ◽

Vol 52 (13) ◽

pp. 3969-3981 ◽

Cited By ~ 36

Author(s):

Gustav Boije af Gennäs ◽

Virpi Talman ◽

Olli Aitio ◽

Elina Ekokoski ◽

Moshe Finel ◽

...

Keyword(s):

Biological Activity ◽

Protein Kinase C ◽

Protein Kinase ◽

Isophthalic Acid ◽

Design Synthesis ◽

Kinase C ◽

C1 Domain

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Mapping Phorbol Ester Binding Domains of Protein Kinase C (PKC): The Design, Synthesis and Biological Activity of Novel Phorbol Ester Dimers

Synthesis ◽

10.1055/s-1999-3656 ◽

1999 ◽

Vol 1999 (S1) ◽

pp. 1401-1406 ◽

Cited By ~ 7

Author(s):

Paul A. Wender

Keyword(s):

Biological Activity ◽

Protein Kinase C ◽

Protein Kinase ◽

Phorbol Ester ◽

Design Synthesis ◽

Binding Domains ◽

Kinase C

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Toward a Biorelevant Structure of Protein Kinase C Bound Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogues for Analysis with Rotational Echo Double Resonance NMR Spectroscopy

Journal of the American Chemical Society ◽

10.1021/jacs.5b00886 ◽

2015 ◽

Vol 137 (10) ◽

pp. 3678-3685 ◽

Cited By ~ 19

Author(s):

Brian A. Loy ◽

Adam B. Lesser ◽

Daryl Staveness ◽

Kelvin L. Billingsley ◽

Lynette Cegelski ◽

...

Keyword(s):

Protein Kinase C ◽

Nmr Spectroscopy ◽

Protein Kinase ◽

Double Resonance ◽

Design Synthesis ◽

Kinase C ◽

Rotational Echo Double Resonance

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Design, Synthesis, and Investigation of Protein Kinase C Inhibitors: Total Syntheses of (+)-Calphostin D, (+)-Phleichrome, Cercosporin, and New Photoactive Perylenequinones

Journal of the American Chemical Society ◽

10.1021/ja902324j ◽

2009 ◽

Vol 131 (26) ◽

pp. 9413-9425 ◽

Cited By ~ 43

Author(s):

Barbara J. Morgan ◽

Sangeeta Dey ◽

Steven W. Johnson ◽

Marisa C. Kozlowski

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Design Synthesis ◽

Total Syntheses ◽

Protein Kinase C Inhibitors ◽

Kinase C

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Design, synthesis and investigation of mechanisms of action of novel protein kinase C inhibitors: perylenequinonoid pigments

Biochemical Pharmacology ◽

10.1016/0006-2952(94)90029-9 ◽

1994 ◽

Vol 47 (2) ◽

pp. 373-385 ◽

Cited By ~ 47

Author(s):

Zhenjun Diwu ◽

Jürg Zimmermann ◽

Th. Meyer ◽

J.William Lown

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Mechanisms Of Action ◽

Design Synthesis ◽

Protein Kinase C Inhibitors ◽

Kinase C ◽

Novel Protein

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Modulation of tight junction (TJ) structure by enteroinvasive E. coli (EIEC) is prevented by H2O2 scavengers and protein kinase C(PKC) inhibitors

Gastroenterology ◽

10.1016/s0016-5085(01)83509-5 ◽

2001 ◽

Vol 120 (5) ◽

pp. A705-A705

Author(s):

S RESTALENERT ◽

K BARRETT

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Tight Junction ◽

E Coli ◽

Kinase C ◽

Pkc Inhibitors

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Protein kinase C (PKC)-β1 mediates EGF-induced protection of the microtubule (MT) cytoskeleton & intestinal barrier function (BF) against oxidant injury

Gastroenterology ◽

10.1016/s0016-5085(01)83491-0 ◽

2001 ◽

Vol 120 (5) ◽

pp. A701-A701

Author(s):

A BANAN ◽

J FIELDS ◽

Y ZHANG ◽

E MUTLU ◽

A KESHAVARZIAN

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Barrier Function ◽

Intestinal Barrier ◽

Intestinal Barrier Function ◽

Oxidant Injury ◽

Kinase C

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