2,3-Dihalo-1-propenes as Building Blocks in Cu(I)-Catalyzed Domino Reactions: Efficient and Selective Synthesis of Furans

2014 ◽  
Vol 16 (18) ◽  
pp. 4862-4865 ◽  
Author(s):  
Dietmar Schmidt ◽  
Chandi C. Malakar ◽  
Uwe Beifuss
Keyword(s):  
Building Blocks ◽  
Selective Synthesis ◽  
Domino Reactions

ChemInform Abstract: Selective Synthesis of Polyfunctionalized Pyrido[2,3-b]indoles by Multicomponent Domino Reactions.

ChemInform ◽  
2015 ◽  
Vol 46 (10) ◽  
pp. no-no
Author(s):  
Jun-Die Hu ◽  
Cheng-Pao Cao ◽  
Wei Lin ◽  
Ming-Hua Hu ◽  
Zhi-Bin Huang ◽  
...  
Keyword(s):  
Selective Synthesis ◽  
Domino Reactions

scholarly journals Domino reactions of cyclic enaminones leading to selective synthesis of pentacyclic indoles and its functionalization

Tetrahedron ◽  
2016 ◽  
Vol 72 (32) ◽  
pp. 4867-4877 ◽  
Author(s):  
Wei Fan ◽  
Yan-Rong Li ◽  
Qun Li ◽  
Bo Jiang ◽  
Guigen Li
Keyword(s):  
Selective Synthesis ◽  
Domino Reactions ◽  
Cyclic Enaminones

Selective Synthesis of Polyfunctionalized Pyrido[2,3-b]indoles by Multicomponent Domino Reactions

2014 ◽  
Vol 79 (17) ◽  
pp. 7935-7944 ◽  
Author(s):  
Jun-Die Hu ◽  
Cheng-Pao Cao ◽  
Wei Lin ◽  
Ming-Hua Hu ◽  
Zhi-Bin Huang ◽  
...  
Keyword(s):  
Selective Synthesis ◽  
Domino Reactions

scholarly journals Polyhalonitrobutadienes as Versatile Building Blocks for the Biotargeted Synthesis of Substituted N-Heterocyclic Compounds

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2863 ◽  
Author(s):  
Viktor A. Zapol’skii ◽  
Ursula Bilitewski ◽  
Sören R. Kupiec ◽  
Isabell Ramming ◽  
Dieter E. Kaufmann
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Heterocyclic Compounds ◽  
Nitrogen Heterocycles ◽  
Building Blocks ◽  
Antibacterial Activities ◽  
Synthetic Approach ◽  
Selective Synthesis ◽  
Ic50 Values ◽  
Thiophene Derivatives

Substituted nitrogen heterocycles are structural key units in many important pharmaceuticals. A new synthetic approach towards heterocyclic compounds displaying antibacterial activity against Staphylococcus aureus or cytotoxic activity has been developed. The selective synthesis of a series of 64 new N-heterocycles from the three nitrobutadienes 2-nitroperchloro-1,3-butadiene, 4-bromotetrachloro-2-nitro-1,3-butadiene and (Z)-1,1,4-trichloro-2,4-dinitrobuta-1,3-diene proved feasible. Their reactions with N-, O- and S-nucleophiles provide rapid access to push-pull substituted benzoxazolines, benzimidazolines, imidazolidines, thiazolidinones, pyrazoles, pyrimidines, pyridopyrimidines, benzoquinolines, isothiazoles, dihydroisoxazoles, and thiophenes with unique substitution patterns. Antibacterial activities of 64 synthesized compounds were examined. Additionally, seven compounds (thiazolidinone, nitropyrimidine, indole, pyridopyrimidine, and thiophene derivatives) exhibited a significant cytotoxicity with IC50-values from 1.05 to 20.1 µM. In conclusion, it was demonstrated that polyhalonitrobutadienes have an interesting potential as structural backbones for a variety of highly functionalized, pharmaceutically active heterocycles.

Microwave-Assisted Domino Reactions of Propargylamines with Isothiocyanates: Selective Synthesis of 2-Aminothiazoles and 2-Amino-4-methylenethiazolines

Synlett ◽  
2016 ◽  
Vol 27 (12) ◽  
pp. 1883-1887 ◽  
Author(s):  
Daniele Castagnolo ◽  
Nicoló Scalacci ◽  
Chiara Pelloja ◽  
Marco Radi
Keyword(s):  
Selective Synthesis ◽  
Domino Reactions ◽  
Microwave Assisted

Cu ion-exchanged and Cu nanoparticles decorated mesoporous ZSM-5 catalysts for the activation and utilization of phenylacetylene in a sustainable chemical synthesis

RSC Advances ◽  
2016 ◽  
Vol 6 (90) ◽  
pp. 87066-87081 ◽  
Author(s):  
Bhaskar Sarmah ◽  
Biswarup Satpati ◽  
Rajendra Srivastava
Keyword(s):  
Chemical Synthesis ◽  
External Surface ◽  
Building Blocks ◽  
Selective Synthesis ◽  
Cu Nanoparticles ◽  
Excellent Activity ◽  
Highly Dispersed

Highly dispersed Cu nanoparticles supported on the large external surface of Meso-ZSM-5 exhibited excellent activity in the selective synthesis of indolizines, chalcones, and triazoles using phenylacetylene as one of the building blocks.

scholarly journals Base-Promoted Selective Synthesis of 2H-Pyranones and Tetrahydronaphthalenes via Domino Reactions

ACS Omega ◽  
2017 ◽  
Vol 2 (8) ◽  
pp. 4900-4910 ◽  
Author(s):  
Solaimalai Thimmarayaperumal ◽  
Sivakumar Shanmugam
Keyword(s):  
Selective Synthesis ◽  
Domino Reactions
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