Cu-Catalyzed C(sp3)–H Bond Activation Reaction for Direct Preparation of Cycloallyl Esters from Cycloalkanes and Aromatic Aldehydes

2014 ◽  
Vol 16 (9) ◽  
pp. 2530-2533 ◽  
Author(s):  
Jincan Zhao ◽  
Hong Fang ◽  
Jianlin Han ◽  
Yi Pan
Keyword(s):  
Bond Activation ◽  
Aromatic Aldehydes ◽  
Activation Reaction ◽  
Direct Preparation

Cu-catalyzed C–H Activation Reaction: One Pot Direct Synthesis of Xanthine and Uric Acid Derivatives from 5-Bromo Uracil

Synlett ◽  
2021 ◽  
Author(s):  
Habibur Rahaman ◽  
Brindaban Roy ◽  
Somjit Hazra ◽  
Biplab Mondal
Keyword(s):  
Uric Acid ◽  
Bond Activation ◽  
Direct Synthesis ◽  
One Pot ◽  
Activation Reaction

Abstract: A one pot direct synthesis of xanthine and uric acid derivates is reported. This simple yet efficient methodology illustrates concurrent formation of two C-N bonds using CuBr2 as catalyst and one of those C-N bonds is formed by uracil C6-H bond activation.

scholarly journals Rh-catalyzed decarbonylation of conjugated ynones via carbon–alkyne bond activation: reaction scope and mechanistic exploration via DFT calculations

2015 ◽  
Vol 6 (5) ◽  
pp. 3201-3210 ◽  
Author(s):  
Alpay Dermenci ◽  
Rachel E. Whittaker ◽  
Yang Gao ◽  
Faben A. Cruz ◽  
Zhi-Xiang Yu ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Bond Activation ◽  
Activation Reaction

We report a catalytic C–C bond activation of unstrained conjugated monoynonesviadecarbonylation to synthesize disubstituted alkynes.

scholarly journals Femtosecond Infrared Studies of Chemical Bond Activation

1999 ◽  
Vol 19 (1-4) ◽  
pp. 253-262 ◽  
Author(s):  
M. C. Asplund ◽  
H. Yang ◽  
K. T. Kotz ◽  
S. E. Bromberg ◽  
M. J. Wilkens ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Chemical Bond ◽  
Bond Activation ◽  
Product Formation ◽  
Organometallic Complexes ◽  
Activation Time ◽  
Activation Reaction ◽  
Infrared Studies ◽  
Important Intermediate ◽  
Solvent Complex

The identification of the intermediates observed in bond activation reactions involving organometallic complexes on time scales from femtoseconds to milliseconds has been accomplished through the use of ultrafast infrared spectroscopy. C—H bond activation by the molecule Tp*Rh(CO)2 showed a final activation time of 200 ns in cyclic solvents, indicating a reaction barrier of 8.3 kcal/mol. An important intermediate is the partially dechelated η2-Tp*Rh(CO)(S) solvent complex, which was formed 200 ps after the initial photoexcitation. Si—H bond activation by CpM(CO)3 (M=Mn, Re) showed some product formation in less than 5 ps, indicating that the Si—H activation reaction is barrierless. The activated product was formed on several timescales, from picoseconds to nanoseconds, suggesting that there are different pathways for forming final product which are partitioned by the initial photoexcitation.

scholarly journals Asymmetric Defluoroallylation of 4-Trifluoromethylpyridines Enabled by Umpolung C-F Bond Activation

2022 ◽  
Author(s):  
Fei-Yu Zhou ◽  
Lei Jiao
Keyword(s):  
Bond Activation ◽  
Chiral Center ◽  
Trifluoromethyl Group ◽  
Activation Reaction ◽  
Limited Success ◽  
Important Approach

Carbon-fluorine bond activation reaction of the trifluoromethyl group represent an important approach to fluorine-containing molecules. While selective defluorofunctionalization reactions of CF3-containing substrates have been achieved by invoking difluorocarbocation, difluorocarboradical, or difluoroorganometallic species as the key intermedi-ate, the transformations via fluorocarbanion mechanism remained a limited success. Furthermore, the enantioselective defluorotransformation of CF3 group has not yet been realized. Herein, we report a defluorofunctionalization reaction of 4-trifluoromethylpyridines involving pyridyldifluoromethyl anion as the key intermediate, which was developed based upon our previous studies on the N-boryl pyridyl anion chemistry. When combined with Ir-catalysis, asymmetric defluoroallylation of 4-trifluoromethylpyridines could be achieved to forge a difluoroalkyl-substituted chiral center. The present work opens up a new opportunity for the defluorofunctionalization of CF3 group, and provides new insights into the N-boryl pyridyl anion chemistry.

Sign in / Sign up

Export Citation Format

Share Document