Novel Synthesis of 3-Substituted 2,3-Dihydrobenzofurans via ortho-Quinone Methide Intermediates Generated in Situ

2014 ◽  
Vol 16 (5) ◽  
pp. 1478-1481 ◽  
Author(s):  
Abdul kadar Shaikh ◽  
George Varvounis
Keyword(s):  
Quinone Methide ◽  
Novel Synthesis

Metal-Free Oxidative C(sp3)–N Coupling by HBr and DMSO: A Novel Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Synlett ◽  
2018 ◽  
Vol 29 (07) ◽  
pp. 912-917 ◽  
Author(s):  
Parviz Ranjbar ◽  
Narjes Rezaei ◽  
Ehsan Sheikhi
Keyword(s):  
Oxidative Cyclization ◽  
Cyclization Reaction ◽  
Primary Amines ◽  
Isatoic Anhydride ◽  
Reaction Conditions ◽  
Coupling Process ◽  
Benzylic Alcohols ◽  
Metal Free ◽  
Novel Synthesis

A metal-free oxidative C(sp3)–N coupling process has been developed for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones. The reaction between primary amines, isatoic anhydride, and benzylic alcohols in the presence of HBr in DMSO at 80 °C affords 2,3-dihydroquinazolin-4(1H)-ones in excellent yields. Under these reaction conditions, benzylic alcohols react with in situ generated bromodimethylsulfonium bromide to form alkoxysulfonium intermediates. These intermediates undergo an oxidative cyclization reaction with primary amines and isatoic anhydride to produce the title products.

scholarly journals An ortho-quinone methide based strategy towards the rubromycin spiroketal family

RSC Advances ◽  
2015 ◽  
Vol 5 (98) ◽  
pp. 80212-80215 ◽  
Author(s):  
N. J. Willis ◽  
C. D. Bray
Keyword(s):  
Diels Alder ◽  
Quinone Methide

A method for the generation/in situhetero-Diels–Alder cycloaddition of a trisubstitutedortho-quinone methide (o-QM) is described.

Sulfur synchronously electrodeposited onto exfoliated graphene sheets as a cathode material for advanced lithium–sulfur batteries

2015 ◽  
Vol 3 (32) ◽  
pp. 16513-16519 ◽  
Author(s):  
Liyuan Zhang ◽  
Hui Huang ◽  
Hailin Yin ◽  
Yang Xia ◽  
Jianmin Luo ◽  
...  
Keyword(s):  
Cathode Material ◽  
Graphene Sheets ◽  
Exfoliated Graphene ◽  
Novel Synthesis ◽  
Lithium Sulfur Batteries ◽  
Lithium Sulfur

A novel synthesis of graphene–sulfur composites is designed by electrolytic exfoliation of graphite coupled with in situ electrodeposition of sulfur.

One-pot cascade synthesis of 2,3-disubstituted 2,3-dihydrobenzofurans via ortho-quinone methide intermediates generated in situ

RSC Advances ◽  
2015 ◽  
Vol 5 (19) ◽  
pp. 14892-14896 ◽  
Author(s):  
Abdul kadar Shaikh ◽  
George Varvounis
Keyword(s):  
Cascade Reaction ◽  
Regioselective Synthesis ◽  
Quinone Methide ◽  
One Pot

A simple and efficient one-pot cascade reaction for the regioselective synthesis of trans or cis/trans-2,3-disubstituted 2,3-dihydrobenzofurans, is described.

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