Indium Chloride Catalyzed Alkylative Rearrangement of Propargylic Acetates Using Alkyl Chlorides, Alcohols, and Acetates: Facile Synthesis of α-Alkyl-α,β-Unsaturated Carbonyl Compounds

2014 ◽  
Vol 16 (4) ◽  
pp. 1176-1179 ◽  
Author(s):  
Yoshiharu Onishi ◽  
Yoshihiro Nishimoto ◽  
Makoto Yasuda ◽  
Akio Baba
Keyword(s):  
Carbonyl Compounds ◽  
Facile Synthesis ◽  
Indium Chloride

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

2015 ◽  
Vol 12 (1) ◽  
pp. 3910-3918 ◽  
Author(s):  
Dr Remon M Zaki ◽  
Prof Adel M. Kamal El-Dean ◽  
Dr Nermin A Marzouk ◽  
Prof Jehan A Micky ◽  
Mrs Rasha H Ahmed
Keyword(s):  
Biological Activity ◽  
Carbonyl Compounds ◽  
Mass Spectra ◽  
The Other ◽  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
High Biological Activity ◽  
Basic Hydrolysis ◽  
Pyridine Carboxylate ◽  
Hydrolysis Of

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

Facile Synthesis of Aryl-Substituted 1,2,5,6-Tetrahydropyrimidines and Their Stereochemical Investigation

2004 ◽  
Vol 69 (4) ◽  
pp. 897-904 ◽  
Author(s):  
Valentin A. Chebanov ◽  
Elena A. Muravyova ◽  
Yulia V. Sadchikova ◽  
Sergey M. Desenko ◽  
Vitaly N. Chernenko ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Facile Synthesis ◽  
Unsaturated Ketones ◽  
Nmr Data

The present work is devoted to the investigation of 2,4,6-triaryl-1,2,5,6-tetrahydropyrimidine derivatives. A new facile approach to their synthesis based on the reaction of α,β-unsaturated ketones, carbonyl compounds and ammonia was developed. Some stereochemical features of the compounds obtained were fixed on the base of NMR data (including COSY and NOESY experiments).

A New and Facile Synthesis of 2-Alkenenitriles from Carbonyl Compounds

Synthesis ◽  
1979 ◽  
Vol 1979 (11) ◽  
pp. 890-891 ◽  
Author(s):  
Kazuhiko Tanaka ◽  
Noboru Ono ◽  
Yoshihiro Kubo ◽  
Aritsune Kaji
Keyword(s):  
Carbonyl Compounds ◽  
Facile Synthesis
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