High Efficiency Synthesis of F-18 Fluoromethyl Ethers: An Attractive Alternative for C-11 Methyl Groups in Positron Emission Tomography Radiopharmaceuticals

2013 ◽  
Vol 15 (17) ◽  
pp. 4346-4349 ◽  
Author(s):  
Chansoo Park ◽  
Byoung Se Lee ◽  
Dae Yoon Chi
Keyword(s):  
Positron Emission Tomography ◽  
High Efficiency ◽  
Emission Tomography ◽  
Attractive Alternative ◽  
Methyl Groups ◽  
Positron Emission

scholarly journals 18F-positron-emitting/fluorescent labeled erythrocytes allow imaging of internal hemorrhage in a murine intracranial hemorrhage model

2017 ◽  
Vol 37 (3) ◽  
pp. 776-786 ◽  
Author(s):  
Ye Wang ◽  
Fei-Fei An ◽  
Mark Chan ◽  
Beth Friedman ◽  
Erik A Rodriguez ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Red Blood Cells ◽  
Intracranial Hemorrhage ◽  
Blood Cells ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Tomography ◽  
Attractive Alternative ◽  
Emission Computed Tomography ◽  
Positron Emission

An agent for visualizing cells by positron emission tomography is described and used to label red blood cells. The labeled red blood cells are injected systemically so that intracranial hemorrhage can be visualized by positron emission tomography (PET). Red blood cells are labeled with 0.3 µg of a positron-emitting, fluorescent multimodal imaging probe, and used to non-invasively image cryolesion induced intracranial hemorrhage in a murine model (BALB/c, 2.36 × 108 cells, 100 µCi, <4 mm hemorrhage). Intracranial hemorrhage is confirmed by histology, fluorescence, bright-field, and PET ex vivo imaging. The low required activity, minimal mass, and high resolution of this technique make this strategy an attractive alternative for imaging intracranial hemorrhage. PET is one solution to a spectrum of issues that complicate single photon emission computed tomography (SPECT). For this reason, this application serves as a PET alternative to [99mTc]-agents, and SPECT technology that is used in 2 million annual medical procedures. PET contrast is also superior to gadolinium and iodide contrast angiography for its lack of clinical contraindications.

Positron Emission Tomography of Cocaine Binding Sites on the Dopamine Transporter

1994 ◽  
Author(s):  
Bertha K. Madras ◽  
◽  
David R. Elmaleh ◽  
Peter C. Meltzer ◽  
Anna Y. Liung ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Dopamine Transporter ◽  
Binding Sites ◽  
Emission Tomography ◽  
Positron Emission
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