Diastereoselective Synthesis of β-Heteroaryl syn-α-Methyl-β-Amino Acid Derivatives via a Double Chiral Auxiliary Approach

2013 ◽  
Vol 15 (3) ◽  
pp. 562-565 ◽  
Author(s):  
Jianwei Bian ◽  
David Blakemore ◽  
Joseph S. Warmus ◽  
Jianmin Sun ◽  
Matthew Corbett ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chiral Auxiliary ◽  
Amino Acid Derivatives ◽  
Diastereoselective Synthesis

ChemInform Abstract: Diastereoselective Synthesis of β-Heteroaryl syn-α-Methyl-β-amino Acid Derivatives via a Double Chiral Auxiliary Approach.

ChemInform ◽  
2013 ◽  
Vol 44 (26) ◽  
pp. no-no
Author(s):  
Jianwei Bian ◽  
David Blakemore ◽  
Joseph S. Warmus ◽  
Jianmin Sun ◽  
Matthew Corbett ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chiral Auxiliary ◽  
Amino Acid Derivatives ◽  
Diastereoselective Synthesis

scholarly journals Substrate-controlled Diastereoselective Michael Addition of Alkylidene Malonates by Grignard Reagents

2019 ◽  
Vol 25 (1) ◽  
pp. 116-121
Author(s):  
Wei Zhou ◽  
Qingwei Xiao ◽  
Yuanyuan Chang ◽  
Qifa Liu ◽  
Xiaohao Zang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Michael Addition ◽  
Chiral Auxiliary ◽  
Grignard Reagents ◽  
Amino Acid Derivatives ◽  
Catalyst Free ◽  
Chemical Efficiency

AbstractHerein is described a diastereoselective Michael addition of Grignard reagents to α, β- unsaturated diethyl malonates incorporated with a 2-oxazolidone chiral auxiliary. The catalyst-free Michael addition proceeds with good chemical efficiency and excellent stereoselectivity; and it provides new thoughts to the asymmetric synthesis of β-substituted β3 amino acid derivatives.

Preparation ofβ2-Amino Acid Derivatives (β2hThr,β2hTrp,β2hMet,β2hPro,β2hLys, Pyrrolidine-3-carboxylic Acid) by Using DIOZ as Chiral Auxiliary

2005 ◽  
Vol 88 (8) ◽  
pp. 2235-2250 ◽  
Author(s):  
Francois Gessier ◽  
Laurent Schaeffer ◽  
Thierry Kimmerlin ◽  
Oliver Flögel ◽  
Dieter Seebach
Keyword(s):  
Amino Acid ◽  
Carboxylic Acid ◽  
Chiral Auxiliary ◽  
Amino Acid Derivatives

scholarly journals Diastereoselective Synthesis of Fluorinated, Seven-Membered β-Amino Acid Derivatives via Ring-Closing Metathesis.

ChemInform ◽  
2003 ◽  
Vol 34 (48) ◽  
Author(s):  
Santos Fustero ◽  
Ana Bartolome ◽  
Juan F. Sanz-Cervera ◽  
Maria Sanchez-Rosello ◽  
Juan Garcia Soler ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis

scholarly journals 1-(2,4,6-Triisopropylphenyl)ethylamine: A New Chiral Auxiliary for the Asymmetric Synthesis of γ-Amino Acid Derivatives.

ChemInform ◽  
2007 ◽  
Vol 38 (21) ◽  
Author(s):  
Pascale Cividino ◽  
Sandrine Py ◽  
Philippe Delair ◽  
Andrew E. Greene
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Chiral Auxiliary ◽  
Amino Acid Derivatives

ChemInform Abstract: Hydrogen Bond Controlled anti-Aza-Michael Addition: Diastereoselective Synthesis of Cyclobutene-Containing Amino Acid Derivatives.

ChemInform ◽  
2015 ◽  
Vol 46 (39) ◽  
pp. no-no
Author(s):  
David Tejedor ◽  
Gabriela Mendez-Abt ◽  
Javier Gonzalez-Platas ◽  
Israel Fernandez ◽  
Fernando Garcia-Tellado
Keyword(s):  
Hydrogen Bond ◽  
Amino Acid ◽  
Michael Addition ◽  
Amino Acid Derivatives ◽  
Diastereoselective Synthesis
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