Facile Synthesis of Fully Substituted Dihydro-β-carbolines via Brønsted Acid Promoted Cascade Reactions of α-Indolyl Propargylic Alcohols with Nitrones

2012 ◽  
Vol 14 (23) ◽  
pp. 5848-5851 ◽  
Author(s):  
Lu Wang ◽  
Xin Xie ◽  
Yuanhong Liu
Keyword(s):  
Cascade Reactions ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Facile Synthesis ◽  
Propargylic Alcohols ◽  
Brönsted Acid

Facile synthesis of 9H-pyrrolo[1,2-a]indoles via Brønsted acid catalyzed cascade reactions

2019 ◽  
Vol 55 (97) ◽  
pp. 14613-14616 ◽  
Author(s):  
Kunhua Xu ◽  
Wenming Chen ◽  
Jin Lin ◽  
Guifang Chen ◽  
Biao Wang ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Cascade Reaction ◽  
Bronsted Acid ◽  
Acid System ◽  
Brønsted Acid ◽  
Facile Synthesis ◽  
Brönsted Acid ◽  
Acid Catalyzed

A Brønsted acid system promotes the Friedel–Crafts alkenylation/1,6-addition/condensation cascade reaction of ynones with indoles to access 9H-pyrrolo[1,2-a]indoles.

Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles

2018 ◽  
Vol 5 (19) ◽  
pp. 2805-2809 ◽  
Author(s):  
Chang-Bin Yu ◽  
Jie Wang ◽  
Yong-Gui Zhou
Keyword(s):  
Asymmetric Hydrogenation ◽  
Hydrogenation Process ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Facile Synthesis ◽  
One Pot ◽  
Brönsted Acid ◽  
Palladium Catalyzed ◽  
Intramolecular Condensation

A concise synthesis of chiral indolines has been developed through intramolecular condensation, deprotection and palladium-catalyzed asymmetric hydrogenation in a one-pot process with up to 96% ee. A strong Brønsted acid played an important role in both the formation of indoles and asymmetric hydrogenation process.

Synthesis of 3-Allenylindoles and 3-Dienylindoles by Brønsted Acid Catalyzed Allenylation of 2-Arylindoles with Tertiary Propargylic Alcohols

Synlett ◽  
2009 ◽  
Vol 2009 (12) ◽  
pp. 1985-1989 ◽  
Author(s):  
Roberto Sanz ◽  
Mukut Gohain ◽  
Delia Miguel ◽  
Alberto Martínez ◽  
Félix Rodríguez
Keyword(s):  
Bronsted Acid ◽  
Brønsted Acid ◽  
Propargylic Alcohols ◽  
Brönsted Acid ◽  
Acid Catalyzed

Brønsted Acid Catalyzed Alkylation of Indoles with Tertiary Propargylic Alcohols: Scope and Limitations

2010 ◽  
Vol 2010 (36) ◽  
pp. 7027-7039 ◽  
Author(s):  
Roberto Sanz ◽  
Delia Miguel ◽  
Alberto Martínez ◽  
Mukut Gohain ◽  
Patricia García-García ◽  
...  
Keyword(s):  
Bronsted Acid ◽  
Brønsted Acid ◽  
Propargylic Alcohols ◽  
Brönsted Acid ◽  
Acid Catalyzed

Brønsted acid-catalyzed selective C–C bond cleavage of 1,3-diketones: a facile synthesis of 4(3H)-quinazolinones in aqueous ethyl lactate

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85646-85651 ◽  
Author(s):  
Guanshuo Shen ◽  
Haifeng Zhou ◽  
Peng Du ◽  
Sensheng Liu ◽  
Kun Zou ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Ethyl Lactate ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Facile Synthesis ◽  
Brönsted Acid ◽  
Acid Catalyzed

Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

2014 ◽  
Vol 50 (17) ◽  
pp. 2196-2198 ◽  
Author(s):  
Lin Qiu ◽  
Xin Guo ◽  
Chaoqun Ma ◽  
Huang Qiu ◽  
Shunying Liu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cascade Reactions ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Efficient Synthesis ◽  
Mannich Reactions ◽  
Cyclic Acetals ◽  
Brönsted Acid

Four-component Mannich reactions subsequently followed by an intramolecular oxo-Michael addition were developed to efficiently produce chiral cyclic acetals with high diastereoselectivity and enantioselectivity.

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