Catalyst-Free Aromatic Nucleophilic Substitution of meso-Bromoporphyrins with Azide Anion: Efficient Synthesis and Structural Analyses of meso-Azidoporphyrins

2011 ◽  
Vol 14 (1) ◽  
pp. 190-193 ◽  
Author(s):  
Ken-ichi Yamashita ◽  
Kazuyuki Kataoka ◽  
Motoko S. Asano ◽  
Ken-ichi Sugiura
Keyword(s):  
Nucleophilic Substitution ◽  
Efficient Synthesis ◽  
Aromatic Nucleophilic Substitution ◽  
Azide Anion ◽  
Catalyst Free

scholarly journals Safe Synthesis of 4,7-Dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine and Its SNAr Reactions

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2576 ◽  
Author(s):  
Timofey Chmovzh ◽  
Ekaterina Knyazeva ◽  
Konstantin Lyssenko ◽  
Vadim Popov ◽  
Oleg Rakitin
Keyword(s):  
Liquid Crystals ◽  
Nucleophilic Substitution ◽  
Efficient Synthesis ◽  
Aromatic Nucleophilic Substitution ◽  
Nitrogen Base ◽  
Nitrogen Nucleophiles

A safe and efficient synthesis of 4,7-dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine from the commercial diaminomaleonitrile is reported. Conditions for selective aromatic nucleophilic substitution of one or two bromine atoms by oxygen and nitrogen nucleophiles are found, whereas thiols formed the bis-derivatives only. Buchwald-Hartwig or Ullmann techniques are successful for incorporation of a weak nitrogen base, such as carbazole, into the [1,2,5]thiadiazolo[3,4-d]pyridazine core. The formation of rather stable S…η2-(N=N) bound chains in 4,7-bis(alkylthio)-[1,2,5]thiadiazolo[3,4-d]pyridines makes these compounds promising for the design of liquid crystals.

Solvent-free and efficient synthesis of bicyclic 2-pyridone derivatives for endoplasmic reticulum imaging

2021 ◽  
Author(s):  
Xiaoyun Ran ◽  
Qian Zhou ◽  
Jin Zhang ◽  
Shanqiang Wang ◽  
Gui Wang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Citric Acid ◽  
Core Structure ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
The Core ◽  
Catalyst Free ◽  
Synthesis Approach ◽  
Ethylenediamine Derivatives

Started from citric acid (CA) and ethylenediamine derivatives, a solvent-free, catalyst-free and highly yield synthesis approach for bicyclic 2-pyridones was presented. Continuing to modify the core structure, a series of...

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