Convergent Synthesis and Discovery of a Natural Product-Inspired Paralog-Selective Hsp90 Inhibitor

2011 ◽  
Vol 13 (19) ◽  
pp. 5108-5111 ◽  
Author(s):  
Valer Jeso ◽  
Lisa Cherry ◽  
Todd K. Macklin ◽  
Subhas Chandra Pan ◽  
Philip V. LoGrasso ◽  
...  
Keyword(s):  
Natural Product ◽  
Hsp90 Inhibitor ◽  
Convergent Synthesis

scholarly journals Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis

2016 ◽  
Vol 23 (2) ◽  
pp. 257-266 ◽  
Author(s):  
Dianrong Li ◽  
Chao Li ◽  
Lin Li ◽  
She Chen ◽  
Lei Wang ◽  
...  
Keyword(s):  
Natural Product ◽  
Hsp90 Inhibitor

A Convergent Synthesis of the 2-Formylpyrrole Spiroketal Natural Product Acortatarin A

Synlett ◽  
2012 ◽  
Vol 23 (06) ◽  
pp. 855-858 ◽  
Author(s):  
Margaret Brimble ◽  
Hui Geng ◽  
Jack Chen ◽  
Daniel Furkert ◽  
Shende Jiang
Keyword(s):  
Natural Product ◽  
Convergent Synthesis

150 POSTER MPC-3100: A non-natural product Hsp90 inhibitor with anti-tumor activity in pre-clinical models

2008 ◽  
Vol 6 (12) ◽  
pp. 48 ◽  
Author(s):  
D. Wettstein ◽  
V. Baichwal ◽  
D. Papac ◽  
D. Cimbora ◽  
R. McKinnon ◽  
...  
Keyword(s):  
Natural Product ◽  
Hsp90 Inhibitor ◽  
Clinical Models ◽  
Anti Tumor Activity

Glycal approach to the synthesis of macrolide (−)-A26771B

RSC Advances ◽  
2015 ◽  
Vol 5 (37) ◽  
pp. 29114-29120 ◽  
Author(s):  
Puli Saidhareddy ◽  
Arun K. Shaw
Keyword(s):  
Natural Product ◽  
Convergent Synthesis ◽  
Cross Metathesis ◽  
Yamaguchi Macrolactonization ◽  
Ferrier Rearrangement ◽  
Key Features

A convergent synthesis of macrolide natural product (−)-A26771B starting from d-glucal is reported. Key features of this synthesis involve Ferrier rearrangement, cross metathesis of chiral fragments 3 and 4 and Yamaguchi macrolactonization.

Synthetic studies toward inducamide C

2021 ◽  
Author(s):  
Ardalan A. Nabi ◽  
Lydia M. Scott ◽  
Daniel P. Furkert ◽  
Jonathan Sperry
Keyword(s):  
Natural Product ◽  
Structural Revision ◽  
Synthetic Studies

The rare benzoxazepine ring in the alkaloid inducamide C is unstable and prone to rearrangement, indicating that structural revision of the natural product may be necessary.

Lessons learned from the optimization of natural product based kinase inhibitors through molecular calculations

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
V Myrianthopoulos ◽  
P Magiatis ◽  
AL Skaltsounis ◽  
L Meijer ◽  
E Mikros
Keyword(s):  
Natural Product ◽  
Kinase Inhibitors ◽  
Lessons Learned ◽  
Molecular Calculations
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