scholarly journals Stereospecific Synthesis ofsyn-α-Oximinoamides by a Three-Component Reaction of Isocyanides,syn-Chlorooximes, and Carboxylic Acids

2011 ◽  
Vol 13 (14) ◽  
pp. 3734-3737 ◽  
Author(s):  
Tracey Pirali ◽  
Riccardo Mossetti ◽  
Simona Galli ◽  
Gian Cesare Tron
Keyword(s):  
Carboxylic Acids ◽  
Stereospecific Synthesis ◽  
Three Component Reaction

A non-stereospecific synthesis of (±)-davanone

1970 ◽  
Vol 23 (9) ◽  
pp. 1811 ◽  
Author(s):  
AJ Birch ◽  
JET Corrie ◽  
Rao GSR Subba
Keyword(s):  
Carboxylic Acids ◽  
Stereospecific Synthesis ◽  
Inactive Form ◽  
Relative Stereochemistry ◽  
Steric Control

A synthesis of the optically inactive form of the natural sesquiterpene davanone (1)together with three stereoisomers has been carried out as in Scheme. Although not subject to steric control, the synthesis confirms the structure of davanone, and leads to the suggestion that the relative stereochemistry may be that shown in (16). The preparation and some reactions with carboxylic acids of 3-methylbut-2-enyllithium are described.

Regioselective and Stereospecific Synthesis of β,γ-Unsaturated Carboxylic Acids Using Allylbariums

Synlett ◽  
1992 ◽  
Vol 1992 (07) ◽  
pp. 593-594 ◽  
Author(s):  
Akira Yanagisawa ◽  
Katsutaka Yasue ◽  
Hisashi Yamamoto
Keyword(s):  
Carboxylic Acids ◽  
Stereospecific Synthesis ◽  
Unsaturated Carboxylic Acids

Three-Component Reaction between Alkyl Isocyanides, Dialkyl Acetylenedicarboxylates, and Carboxylic Acids

2011 ◽  
Vol 35 (11) ◽  
pp. 661-663 ◽  
Author(s):  
Alireza Hassanabadi ◽  
Mohammad H. Mosslemin ◽  
Sonia Singh ◽  
Seyyed Ali Shaterchi
Keyword(s):  
Carboxylic Acids ◽  
Dialkyl Acetylenedicarboxylates ◽  
Alkyl Isocyanides ◽  
Three Component Reaction

scholarly journals The Flögel-three-component reaction with dicarboxylic acids – an approach to bis(β-alkoxy-β-ketoenamides) for the synthesis of complex pyridine and pyrimidine derivatives

2014 ◽  
Vol 10 ◽  
pp. 394-404 ◽  
Author(s):  
Mrinal K Bera ◽  
Moisés Domínguez ◽  
Paul Hommes ◽  
Hans-Ulrich Reissig
Keyword(s):  
Dft Calculations ◽  
Carboxylic Acids ◽  
Aromatic Compounds ◽  
Dicarboxylic Acids ◽  
Membered Ring ◽  
Simple Synthesis ◽  
Pyrimidine Derivatives ◽  
Three Component Reaction ◽  
Palladium Catalyzed ◽  
Pyridine And Pyrimidine Derivatives

An extension of the substrate scope of the Flögel-three-component reaction of lithiated alkoxyallenes, nitriles and carboxylic acids is presented. The use of dicarboxylic acids allowed the preparation of symmetrical bis(β-ketoenamides) from simple starting materials in moderate yields. Cyclocondensations of these enamides to 4-hydroxypyridine derivatives or to functionalized pyrimidines efficiently provided symmetrically and unsymmetrically substituted fairly complex (hetero)aromatic compounds containing up to six conjugated aryl and hetaryl groups. In addition, subsequent functionalizations of the obtained heterocycles by palladium-catalyzed couplings or by oxidations are reported. We also describe the simple synthesis of a structurally interesting macrocyclic bispyrimidine derivative incorporating a 17-membered ring, whose configuration was elucidated by DFT calculations and by subsequent reactions.

Synthesis of Aminocarbonyl N-Acylhydrazones by a Three-Component Reaction of Isocyanides, Hydrazonoyl Chlorides, and Carboxylic Acids

2014 ◽  
Vol 16 (20) ◽  
pp. 5332-5335 ◽  
Author(s):  
Mariateresa Giustiniano ◽  
Fiorella Meneghetti ◽  
Valentina Mercalli ◽  
Monica Varese ◽  
Francesco Giustiniano ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Hydrazonoyl Chlorides ◽  
Three Component Reaction
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