scholarly journals Intramolecular Alkene Carboamination Reactions for the Synthesis of Enantiomerically Enriched Tropane Derivatives

2011 ◽  
Vol 13 (11) ◽  
pp. 2962-2965 ◽  
Author(s):  
Danielle M. Schultz ◽  
John P. Wolfe
Keyword(s):  
Tropane Derivatives

A New Synthesis of Tropane Derivatives

1961 ◽  
Vol 83 (24) ◽  
pp. 4999-5003 ◽  
Author(s):  
G. Cignarella ◽  
G. G. Gallo ◽  
E. Testa
Keyword(s):  
New Synthesis ◽  
Tropane Derivatives

scholarly journals Comparative Study of Two Oxidizing Agents, Chloramine T and Iodo-Gen®, for the Radiolabeling of β-CIT with Iodine-131: Relevance for Parkinson’s Disease

2019 ◽  
Vol 12 (1) ◽  
pp. 25
Author(s):  
Ana R. Durante ◽  
Danielle V. Sobral ◽  
Ana C. Miranda ◽  
Érika V. de Almeida ◽  
Leonardo L. Fuscaldi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Comparative Study ◽  
Radiochemical Yield ◽  
Substantia Nigra Pars Compacta ◽  
Oxidizing Agent ◽  
Oxidizing Agents ◽  
Tropane Derivatives ◽  
Chloramine T ◽  
Iodine 131

Parkinson’s disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to alteration of the integrity of dopaminergic transporters (DATs). In recent years, some radiopharmaceuticals have been used in the clinic to evaluate the integrity of DATs. These include tropane derivatives such as radiolabeled β-CIT and FP-CIT with iodine-123 (123I), and TRODAT-1 with metastable technetium-99 (99mTc). Radiolabeling of β-CIT with radioactive iodine is based on electrophilic radioiodination using oxidizing agents, such as Chloramine T or Iodo-Gen®. For the first time, the present work performed a comparative study of the radiolabeling of β-CIT with iodine-131 (131I), using either Chloramine T or Iodo-Gen® as oxidizing agents, in order to improve the radiolabeling process of β-CIT and to choose the most advantageous oxidizing agent to be used in nuclear medicine. Both radiolabeling methods were similar and resulted in high radiochemical yield (> 95%), with suitable 131I-β-CIT stability up to 72 h. Although Chloramine T is a strong oxidizing agent, it was as effective as Iodo-Gen® for β-CIT radiolabeling with 131I, with the advantage of briefer reaction time and solubility in aqueous medium.

Solid phase synthesis of tropane derivatives

1998 ◽  
Vol 39 (9) ◽  
pp. 1059-1062 ◽  
Author(s):  
Daniel Jönsson ◽  
Håkan Molin ◽  
Anders Undén
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Tropane Derivatives

ChemInform Abstract: THE CHEMISTRY OF TROPANE DERIVATIVES, VIII. INVESTIGATIONS ON THE STRUCTURES OF THE TWO ISOMERIC N-OXIDES OF TROPINE

1976 ◽  
Vol 7 (29) ◽  
pp. no-no
Author(s):  
GOTTFRIED WERNER ◽  
MANFRED WIECHMANN ◽  
PAL SCHEIBER ◽  
ALFRED GIEREN ◽  
THOMAS FISCHER ◽  
...  
Keyword(s):  
Tropane Derivatives
Sign in / Sign up

Export Citation Format

Share Document