Organocatalytic Sequential Michael Reactions: Stereoselective Synthesis of Multifunctionalized Tetrahydroindan Derivatives

Peng He; Xiaohua Liu; Jian Shi; Lili Lin; Xiaoming Feng

doi:10.1021/ol1029832

Organocatalytic Sequential Michael Reactions: Stereoselective Synthesis of Multifunctionalized Tetrahydroindan Derivatives

Organic Letters ◽

10.1021/ol1029832 ◽

2011 ◽

Vol 13 (5) ◽

pp. 936-939 ◽

Cited By ~ 39

Author(s):

Peng He ◽

Xiaohua Liu ◽

Jian Shi ◽

Lili Lin ◽

Xiaoming Feng

Keyword(s):

Stereoselective Synthesis ◽

Michael Reactions

Download Full-text

Stereoselective Synthesis of 2,6-cis- and 2,6-trans-Piperidines through Organocatalytic Aza-Michael Reactions: A Facile Synthesis of (+)-Myrtine and (−)-Epimyrtine

Organic Letters ◽

10.1021/ol103064f ◽

2011 ◽

Vol 13 (4) ◽

pp. 796-799 ◽

Cited By ~ 54

Author(s):

Yongcheng Ying ◽

Hyoungsu Kim ◽

Jiyong Hong

Keyword(s):

Stereoselective Synthesis ◽

Facile Synthesis ◽

Michael Reactions

Download Full-text

ChemInform Abstract: Organocatalytic Domino Mannich Aza-Michael Reactions Towards the Stereoselective Synthesis of Highly Substituted Pipecolic Esters.

ChemInform ◽

10.1002/chin.200908168 ◽

2009 ◽

Vol 40 (8) ◽

Author(s):

Souad Khaliel ◽

Mecheril Valsan Nandakumar ◽

Harald Krautscheid ◽

Christoph Schneider

Keyword(s):

Stereoselective Synthesis ◽

Michael Reactions

Download Full-text

Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 1. Stereoselective Synthesis of the C1-C13 FragmentviaConstruction of the B and A Rings by Kinetically and thermodynamically Controlled Intramolecular Michael Reactions.

Synlett ◽

10.1055/s-1994-22730 ◽

1994 ◽

Vol 1994 (01) ◽

pp. 38-40 ◽

Cited By ~ 26

Author(s):

K. Horita ◽

S. Hachiya ◽

M. Nagasawa ◽

M. Hikota ◽

O. Yonemitsu

Keyword(s):

Marine Sponge ◽

Stereoselective Synthesis ◽

Halichondrin B ◽

Michael Reactions ◽

Synthetic Studies

Download Full-text

ChemInform Abstract: Organocatalytic Sequential Michael Reactions: Stereoselective Synthesis of Multifunctionalized Tetrahydroindan Derivatives.

ChemInform ◽

10.1002/chin.201122086 ◽

2011 ◽

Vol 42 (22) ◽

pp. no-no

Author(s):

Peng He ◽

Xiaohua Liu ◽

Jian Shi ◽

Lili Lin ◽

Xiaoming Feng

Keyword(s):

Stereoselective Synthesis ◽

Michael Reactions

Download Full-text

ChemInform Abstract: Thionium Ion Promoted Michael Acceptor: A Sequence of Pummerer/Michael Reactions for the Stereoselective Synthesis of 5-(1-(Arylthio)vinyl)-oxazolines.

ChemInform ◽

10.1002/chin.201428116 ◽

2014 ◽

Vol 45 (28) ◽

pp. no-no

Author(s):

Shimin Xu ◽

Qianyun Zhang ◽

Hongwei Zhou

Keyword(s):

Stereoselective Synthesis ◽

Michael Reactions ◽

Michael Acceptor

Download Full-text

Thionium ion promoted Michael acceptor: a sequence of Pummerer/Michael reactions for the stereoselective synthesis of 5-(1-(arylthio)vinyl)-oxazolines

Tetrahedron Letters ◽

10.1016/j.tetlet.2013.12.112 ◽

2014 ◽

Vol 55 (6) ◽

pp. 1196-1198 ◽

Cited By ~ 2

Author(s):

Shimin Xu ◽

Qianyun Zhang ◽

Hongwei Zhou

Keyword(s):

Stereoselective Synthesis ◽

Michael Reactions ◽

Michael Acceptor

Download Full-text

Organocatalytic Domino Mannich Aza-Michael Reactions towards the Stereoselective Synthesis of Highly Substituted Pipecolic Esters

Synlett ◽

10.1055/s-0028-1083377 ◽

2008 ◽

Vol 2008 (17) ◽

pp. 2705-2707 ◽

Cited By ~ 2

Author(s):

Christoph Schneider ◽

Souad Khaliel ◽

Mecheril Nandakumar ◽

Harald Krautscheid

Keyword(s):

Stereoselective Synthesis ◽

Michael Reactions

Download Full-text

Stereoselective Synthesis of the A,E-Ring Bicyclic Core of Calyciphylline B-Type Alkaloids

Synlett ◽

10.1055/s-0039-1690721 ◽

2019 ◽

Vol 30 (19) ◽

pp. 2157-2160

Author(s):

Balagani Satish Kumar ◽

Sadagopan Raghavan

Keyword(s):

Claisen Rearrangement ◽

Stereoselective Synthesis ◽

Oxidative Cleavage ◽

Mitsunobu Reaction ◽

Subsequent Reduction ◽

Enzymatic Resolution ◽

Michael Reactions

A stereoselective synthesis of the bicyclic unit constituting the A and E rings of calyciphylline B-type alkaloids is disclosed. The propionate ester of (1R)-cyclohex-2-en-1-ol, obtained by enzymatic resolution, is subjected to an Ireland–Claisen rearrangement. Subsequent reduction of the acid, Mitsunobu reaction to introduce a nitrogen functionality, oxidative cleavage to a dialdehyde, and intramolecular aldol and aza-Michael reactions afford the bicyclic subunit.

Download Full-text