Asymmetric Synthesis of Both Mirror Images of 3′-Fluorothalidomide by Enantiodivergent Fluorination Using a Single, Cinchona Alkaloid

2011 ◽  
Vol 13 (3) ◽  
pp. 470-473 ◽  
Author(s):  
Takeshi Yamamoto ◽  
Yuka Suzuki ◽  
Emi Ito ◽  
Etsuko Tokunaga ◽  
Norio Shibata
Keyword(s):  
Asymmetric Synthesis ◽  
Cinchona Alkaloid

Cinchona Alkaloid Catalyzed Asymmetric Synthesis of Chiral Aldehydes

Synfacts ◽  
2006 ◽  
Vol 2006 (8) ◽  
pp. 0841-0841
Author(s):  
L. Deng ◽  
F. Wu ◽  
R. Hong ◽  
J. Khan ◽  
X. Liu
Keyword(s):  
Asymmetric Synthesis ◽  
Cinchona Alkaloid

Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts

2018 ◽  
Vol 16 (45) ◽  
pp. 8704-8709 ◽  
Author(s):  
Weihua Li ◽  
Yifeng Wang ◽  
Danqian Xu
Keyword(s):  
Asymmetric Synthesis ◽  
Nucleophilic Addition ◽  
Phase Transfer ◽  
Cinchona Alkaloid ◽  
Reaction Products ◽  
Chiral Phase ◽  
Phase Transfer Catalysts ◽  
Chiral Phase Transfer Catalysts ◽  
The Mannich Reaction ◽  
High Yields

A highly enantioselective nucleophilic addition of ketones to versatile imines catalyzed by chiral PTC has been developed, and the process affords the Mannich reaction products with tertiary stereocenters in good to high yields and excellent enantioselectivities. This protocol is effective for gram scale reaction.

scholarly journals The Rational Design of Modified Cinchona Alkaloid Catalysts. Application to a New Asymmetric Synthesis of Chiral Chromanes.

ChemInform ◽  
2004 ◽  
Vol 35 (38) ◽  
Author(s):  
Alain Merschaert ◽  
Pieter Delbeke ◽  
Desire Daloze ◽  
Georges Dive
Keyword(s):  
Asymmetric Synthesis ◽  
Rational Design ◽  
Cinchona Alkaloid

scholarly journals One-pot Fluorination and Organocatalytic Robinson Annulation for Asymmetric Synthesis of Mono- and Difluorinated Cyclohexenones

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2251 ◽  
Author(s):  
Xin Huang ◽  
Weizhao Zhao ◽  
Xiaofeng Zhang ◽  
Miao Liu ◽  
Stanley Vasconcelos ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Cinchona Alkaloid ◽  
One Pot ◽  
Robinson Annulation

A one-pot fluorination and organocatalytic Robinson annulation sequence has been developed for asymmetric synthesis of 6-fluoroyclohex-2-en-1-ones and 4,6-difluorocyclohex-2-en-1-ones. The reactions promoted by cinchona alkaloid amine afforded products bearing two or three stereocenters in good to excellent yields with up to 99% ee and 20:1 dr.

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