Tandem Nucleophilic Addition−Intramolecular Aza-Michael Reaction: Facile Synthesis of Chiral Fluorinated Isoindolines

2010 ◽  
Vol 12 (23) ◽  
pp. 5494-5497 ◽  
Author(s):  
Santos Fustero ◽  
Javier Moscardó ◽  
María Sánchez-Roselló ◽  
Elsa Rodríguez ◽  
Pablo Barrio
Keyword(s):  
Nucleophilic Addition ◽  
Michael Reaction ◽  
Facile Synthesis

ChemInform Abstract: Tandem Nucleophilic Addition-Intramolecular Aza-Michael Reaction: Facile Synthesis of Chiral Fluorinated Isoindolines.

ChemInform ◽  
2011 ◽  
Vol 42 (12) ◽  
pp. no-no
Author(s):  
Santos Fustero ◽  
Javier Moscardo ◽  
Maria Sanchez-Rosello ◽  
Elsa Rodriguez ◽  
Pablo Barrio
Keyword(s):  
Nucleophilic Addition ◽  
Michael Reaction ◽  
Facile Synthesis

A Facile Synthesis of a Spironitrone and a Study of Its Cycloaddition and Nucleophilic Addition Reactions

Synthesis ◽  
2008 ◽  
Vol 2008 (20) ◽  
pp. 3319-3325
Author(s):  
Margaret Brimble ◽  
Daryl Crimmins ◽  
Ivaylo Dimitrov ◽  
Patrick O’Connor ◽  
Vittorio Caprio
Keyword(s):  
Nucleophilic Addition ◽  
Addition Reactions ◽  
Facile Synthesis

Mechanism of Mukaiyama−Michael Reaction of Ketene Silyl Acetal:  Electron Transfer or Nucleophilic Addition?

1996 ◽  
Vol 61 (9) ◽  
pp. 2951-2962 ◽  
Author(s):  
Junzo Otera ◽  
Yukihiro Fujita ◽  
Nobuyuki Sakuta ◽  
Morifumi Fujita ◽  
Shunichi Fukuzumi
Keyword(s):  
Electron Transfer ◽  
Nucleophilic Addition ◽  
Michael Reaction

Facile synthesis of quinoxaline-2-thiol and quinoxaline from α-oxo sulfines and o-aryl diamines

Synthesis ◽  
2022 ◽  
Author(s):  
Jun Dong ◽  
Youwei Chen ◽  
Xingcai Huang
Keyword(s):  
Reaction Mechanism ◽  
Nucleophilic Addition ◽  
Current Method ◽  
Facile Synthesis ◽  
Simple Strategy

A series of quinoxaline-2-thiol and quinoxaline were prepared in moderate to good yields from various phenacyl sulfoxides bearing 1-methyl-1H-tetrazole and o-aryl diamines. The proposed reaction mechanism involves generation of sulfines from the phenacyl sulfoxides bearing 1-methyl-1H-tetrazole through thermolysis elimination. Then, site-selectively carbophilic addition of sulfines by o-aryl diamines, followed by elimination, intramolecular nucleophilic addition and dehydration condensation. The current method provides a direct and simple strategy for the preparation of quinoxaline-2-thiols and quinoxalines.

ChemInform Abstract: Tandem Nucleophilic Addition/Oxa-Michael Reaction for the Synthesis of cis-2,6-Disubstituted Tetrahydropyrans.

ChemInform ◽  
2015 ◽  
Vol 46 (6) ◽  
pp. no-no
Author(s):  
Santosh J. Gharpure ◽  
J. V. K. Prasad ◽  
Kalisankar Bera
Keyword(s):  
Nucleophilic Addition ◽  
Michael Reaction
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