scholarly journals Dragmacidin E Synthesis Studies. Preparation of a Model Heptacyclic Core Structure

2010 ◽  
Vol 12 (20) ◽  
pp. 4502-4505 ◽  
Author(s):  
Ken S. Feldman ◽  
Paiboon Ngernmeesri
Keyword(s):  
2017 ◽  
Vol 82 (5) ◽  
pp. 2787-2793 ◽  
Author(s):  
Naoya Inoue ◽  
Shun-ichi Nakano ◽  
Shingo Harada ◽  
Yasumasa Hamada ◽  
Tetsuhiro Nemoto

1983 ◽  
Vol 44 (C4) ◽  
pp. C4-37-C4-42 ◽  
Author(s):  
K. W. Lodge ◽  
A. Lapiccirella ◽  
N. Tomassini ◽  
S. L. Altmann

1988 ◽  
Vol 49 (C5) ◽  
pp. C5-251-C5-256 ◽  
Author(s):  
K. L. MERKLE ◽  
J. F. REDDY ◽  
C. L. WILEY ◽  
D. J. SMITH
Keyword(s):  

2020 ◽  
Vol 35 (10) ◽  
pp. 1000-1005
Author(s):  
Jian LI ◽  
◽  
Zhao-yi CHE ◽  
Ling-chao MO ◽  
Ming-gang HU ◽  
...  

2020 ◽  
Author(s):  
Xuan Zhang ◽  
Yanjun Tong ◽  
Xiaomei Lyu ◽  
Jianfen Ye ◽  
Ruijin Yang

Author(s):  
Hideko Abe

This article discusses how the intersection of grammatical gender and social gender, entwined in the core structure of language, can be analyzed to understand the dynamic status of selfhood. After reviewing a history of scholarship that demonstrates this claim, the discussion analyzes the language practices of transgender individuals in Japan, where transgender identity is currently understood in terms of sei-dōitsusei-shōgai (gender identity disorder). Based on fieldwork conducted between 2011 and 2017, the analysis reveals how individuals identifying with sei-dōitsusei-shōgai negotiate subject positions by manipulating the specific indexical meanings attached to grammatical structures.


2021 ◽  
Vol 22 (5) ◽  
pp. 2409
Author(s):  
Anastasia A. Bizyaeva ◽  
Dmitry A. Bunin ◽  
Valeria L. Moiseenko ◽  
Alexandra S. Gambaryan ◽  
Sonja Balk ◽  
...  

Nucleic acid aptamers are generally accepted as promising elements for the specific and high-affinity binding of various biomolecules. It has been shown for a number of aptamers that the complexes with several related proteins may possess a similar affinity. An outstanding example is the G-quadruplex DNA aptamer RHA0385, which binds to the hemagglutinins of various influenza A virus strains. These hemagglutinins have homologous tertiary structures but moderate-to-low amino acid sequence identities. Here, the experiment was inverted, targeting the same protein using a set of related, parallel G-quadruplexes. The 5′- and 3′-flanking sequences of RHA0385 were truncated to yield parallel G-quadruplex with three propeller loops that were 7, 1, and 1 nucleotides in length. Next, a set of minimal, parallel G-quadruplexes with three single-nucleotide loops was tested. These G-quadruplexes were characterized both structurally and functionally. All parallel G-quadruplexes had affinities for both recombinant hemagglutinin and influenza virions. In summary, the parallel G-quadruplex represents a minimal core structure with functional activity that binds influenza A hemagglutinin. The flanking sequences and loops represent additional features that can be used to modulate the affinity. Thus, the RHA0385–hemagglutinin complex serves as an excellent example of the hypothesis of a core structure that is decorated with additional recognizing elements capable of improving the binding properties of the aptamer.


2021 ◽  
Vol 115 ◽  
pp. 111016
Author(s):  
Jihai Duan ◽  
Pengxia Sun ◽  
Hui Zhao ◽  
Zhengnan Ji ◽  
Delu Zhang ◽  
...  

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