scholarly journals Total Synthesis of Rhazinilam: Axial to Point Chirality Transfer in an Enantiospecific Pd-Catalyzed Transannular Cyclization

2010 ◽  
Vol 12 (19) ◽  
pp. 4224-4227 ◽  
Author(s):  
Zhenhua Gu ◽  
Armen Zakarian
Keyword(s):  
Total Synthesis ◽  
Chirality Transfer ◽  
Transannular Cyclization

Golden opportunities in catalysis

2008 ◽  
Vol 80 (5) ◽  
pp. 1063-1069 ◽  
Author(s):  
Norbert Krause ◽  
Volker Belting ◽  
Carl Deutsch ◽  
Jörg Erdsack ◽  
Hong-Tao Fan ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
High Reactivity ◽  
Donor Ligands ◽  
Cyclization Product ◽  
Chirality Transfer ◽  
Key Features ◽  
Stereogenic Center

The gold-catalyzed endo-cycloisomerization of allenes bearing nucleophilic substituents in the α- or β-position opens up a versatile access to various five- and six-membered heterocycles. Key features of these transformations are the high reactivity of the allene in the presence of Lewis-acidic, carbophilic gold(I) or gold(III) catalysts, and the chirality transfer from the allenic axis of chirality to the new stereogenic center in the cyclization product. Recent contributions of our group include the optimization of chirality transfer by using σ-donor ligands to gold, and applications in the total synthesis of natural products, e.g., of the β-carboline alkaloids (-)-isocyclocapitelline and (-)-isochrysotricine.

Asymmetric Total Synthesis of (+)-Brefeldin A from (S)-Lactate by Triple Chirality Transfer Process and Nitrile Oxide Cycloaddition†,1

2002 ◽  
Vol 67 (3) ◽  
pp. 764-771 ◽  
Author(s):  
Deukjoon Kim ◽  
Jongkook Lee ◽  
Phil Jong Shim ◽  
Joong Inn Lim ◽  
Hyunil Jo ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Transfer Process ◽  
Brefeldin A ◽  
Nitrile Oxide ◽  
Asymmetric Total Synthesis ◽  
Chirality Transfer

Asymmetric Total Synthesis of (+)‐Neooxazolomycin Using a Chirality‐Transfer Strategy

2019 ◽  
Vol 58 (32) ◽  
pp. 11018-11022 ◽  
Author(s):  
Jae Hyun Kim ◽  
Illan Kim ◽  
Yeonghun Song ◽  
Min Jung Kim ◽  
Sanghee Kim
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis ◽  
Chirality Transfer
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