Convenient Method for the Preparation of Weinreb Amides via Pd-Catalyzed Aminocarbonylation of Aryl Bromides at Atmospheric Pressure

2006 ◽  
Vol 8 (21) ◽  
pp. 4843-4846 ◽  
Author(s):  
Joseph R. Martinelli ◽  
Dominique M. M. Freckmann ◽  
Stephen L. Buchwald
Keyword(s):  
Convenient Method ◽  
Atmospheric Pressure ◽  
Weinreb Amides ◽  
Aryl Bromides

ChemInform Abstract: Palladium-Catalyzed Carbonylation Reactions of Aryl Bromides at Atmospheric Pressure: A General System Based on Xantphos.

ChemInform ◽  
2009 ◽  
Vol 40 (5) ◽  
Author(s):  
Joseph R. Martinelli ◽  
Donald A. Watson ◽  
Dominique M. M. Freckmann ◽  
Timothy E. Barder ◽  
Stephen L. Buchwald
Keyword(s):  
Atmospheric Pressure ◽  
General System ◽  
Aryl Bromides ◽  
Palladium Catalyzed

scholarly journals Palladium-Catalyzed Carbonylation Reactions of Aryl Bromides at Atmospheric Pressure: A General System Based on Xantphos

2008 ◽  
Vol 73 (18) ◽  
pp. 7102-7107 ◽  
Author(s):  
Joseph R. Martinelli ◽  
Donald A. Watson ◽  
Dominique M. M. Freckmann ◽  
Timothy E. Barder ◽  
Stephen L. Buchwald
Keyword(s):  
Atmospheric Pressure ◽  
General System ◽  
Aryl Bromides ◽  
Palladium Catalyzed

A Convenient Method for the Conversion of Hindered Carboxylic Acids toN-Methoxy-N-methyl (Weinreb) Amides

2004 ◽  
Vol 69 (25) ◽  
pp. 8984-8986 ◽  
Author(s):  
Jacqueline C. S. Woo ◽  
Erik Fenster ◽  
Gregory R. Dake
Keyword(s):  
Carboxylic Acids ◽  
Convenient Method ◽  
Weinreb Amides

scholarly journals A Convenient Method of the Conversion of Hindered Carboxylic Acids to N-Methoxy-N-methyl (Weinreb) Amides.

ChemInform ◽  
2005 ◽  
Vol 36 (19) ◽  
Author(s):  
Jacqueline C. S. Woo ◽  
Erik Fenster ◽  
Gregory R. Dake
Keyword(s):  
Carboxylic Acids ◽  
Convenient Method ◽  
Weinreb Amides

scholarly journals PALLADIUM-CATALYZED ALKOXYCARBONYLATION OF ARYL BROMIDES AT ATMOSPHERIC PRESSURE

2021 ◽  
pp. 26-36
Author(s):  
Алексей Владимирович Быков ◽  
Галина Николаевна Демиденко ◽  
Дмитрий Александрович Паньков
Keyword(s):  
Liquid Phase ◽  
Catalytic System ◽  
Atmospheric Pressure ◽  
Reaction Mass ◽  
Phosphine Ligand ◽  
Aryl Bromides ◽  
Palladium Catalyzed

Исследование развивает направление каталитического алкоксикарбонилирования арилбромидов в жидкой фазе при атмосферном давлении. В качестве каталитической системы предложена система на основе бисацетонитрилхлорида палладия, стабилизированного в промышленной полистирольной сетке MN100. В ходе исследования было изучено влияние природы фосфинового лиганда, температуры реакционной массы, а также соотношения субстрат: катализатор на скорость и интегральную селективность процесса жидкофазного алкоксикарбонилирования пара-броманизола газообразным оксидом углерода (II). Исследована активность процесса в присутствии трифенилфосфина, трифенилфосфиноксида и 4,5-бис(дифенилфосфино)-9,9-диметилксантана. The study develops the direction of catalytic alkoxycarbonylation of aryl bromides in the liquid phase at atmospheric pressure. A catalyst based on palladium bisacetonitrile chloride stabilized in an industrial MN100 polystyrene mesh is proposed as a catalytic system. In the course of the study, the influence of the nature of the phosphine ligand, the temperature of the reaction mass was studied. The effect of the substrate-to-catalyst ratio on the rate and integral selectivity of the liquid-phase alkoxycarbonylation of para-bromanisole with carbon (II) oxide gas was also studied. The activity of the process was studied in the presence of triphenylphosphine, triphenylphosphinoxide, and in the presence of 4,5-bis (diphenylphosphino)-9,9-dimethylxanthane.

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