Synthesis of the C29−C37 Bicyclic Ether Core of (+)-Sorangicin A

2006 ◽  
Vol 8 (19) ◽  
pp. 4223-4225 ◽  
Author(s):  
Michael T. Crimmins ◽  
Matthew W. Haley
Keyword(s):  
Sorangicin A

scholarly journals RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus

2000 ◽  
Vol 44 (11) ◽  
pp. 3163-3166 ◽  
Author(s):  
Alexander O'Neill ◽  
Brunello Oliva ◽  
Christopher Storey ◽  
Anthony Hoyle ◽  
Colin Fishwick ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Drug Development ◽  
Rna Polymerase ◽  
Gene Mutations ◽  
Β Subunit ◽  
Polymerase Inhibitors ◽  
Resistant Mutants ◽  
Sorangicin A

ABSTRACT A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase β-subunit (rpoB) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, and ripostatin A retained activity against the rpoB mutants. The second group of inhibitors may be of interest as drug development candidates.

scholarly journals Total Synthesis of (+)-Sorangicin A

2009 ◽  
Vol 131 (34) ◽  
pp. 12109-12111 ◽  
Author(s):  
Amos B. Smith ◽  
Shuzhi Dong ◽  
Jehrod B. Brenneman ◽  
Richard J. Fox
Keyword(s):  
Total Synthesis ◽  
Sorangicin A

Antibiotika aus Gleitenden Bakterien, XXXVIII. Natürliche Strukturvarianten von Sorangicin A ausSorangium cellulosum, So ce12

1989 ◽  
Vol 1989 (3) ◽  
pp. 213-222 ◽  
Author(s):  
Rolf Jansen ◽  
Gerhard Höfle ◽  
Herbert Irschik ◽  
Hans Reichenbach ◽  
Victor Wray
Keyword(s):  
Sorangicin A
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