Catalytic Asymmetric Simmons−Smith Cyclopropanation of Silyl Enol Ethers. Efficient Synthesis of Optically Active Cyclopropanol Derivatives

2006 ◽  
Vol 8 (13) ◽  
pp. 2827-2829 ◽  
Author(s):  
Haifeng Du ◽  
Jiang Long ◽  
Yian Shi
Keyword(s):  
Optically Active ◽  
Efficient Synthesis ◽  
Enol Ethers ◽  
Silyl Enol Ethers ◽  
Catalytic Asymmetric

scholarly journals Direct Access to Mono-Protected Homoallylic 1,2-Diols via Dual Chromium/ Photoredox Catalysis

2020 ◽  
Author(s):  
Felix Schäfers ◽  
Linda Quach ◽  
J. Luca Schwarz ◽  
Mar Saladrigas ◽  
Constantin G. Daniliuc ◽  
...  
Keyword(s):  
Functional Group ◽  
Protecting Groups ◽  
Direct Access ◽  
Photoredox Catalysis ◽  
Efficient Synthesis ◽  
Enol Ethers ◽  
Silyl Enol Ethers

<p>A dual catalytic strategy enables the efficient synthesis of mono-protected homoallylic 1,2-diols by coupling abundant aldehydes with simple (silyl) enol ethers, thus providing direct access to this important motif without the (super)stoichiometric use of prefunctionalized metal-allyl species. A variety of silyl- and alkyl-based protecting groups is shown and functional group tolerance, chemoselectivity and scalability are highlighted. </p>

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