Total Synthesis of (+)-Phomopsolide C by Ring-Size Selective Ring-Closing Metathesis/Cross-Metathesis

2005 ◽  
Vol 7 (24) ◽  
pp. 5513-5516 ◽  
Author(s):  
Simon Michaelis ◽  
Siegfried Blechert
Keyword(s):  
Total Synthesis ◽  
Ring Size ◽  
Ring Closing Metathesis ◽  
Cross Metathesis

Synthesis of an analog of mycothiazole and total synthesis of pseudotrienic acid B

2007 ◽  
Vol 79 (4) ◽  
pp. 677-684 ◽  
Author(s):  
Dominique Amans ◽  
Alexandre Le Flohic ◽  
Véronique Bellosta ◽  
Christophe Meyer ◽  
Janine Cossy
Keyword(s):  
Total Synthesis ◽  
Ring Closing Metathesis ◽  
Cross Metathesis

An analog of mycothiazole and pseudotrienic acid B were synthesized efficiently by using ring-closing metathesis or cross-metathesis as key reactions.

scholarly journals Recent Advances in Total Synthesis via Metathesis Reactions

Synthesis ◽  
2018 ◽  
Vol 50 (19) ◽  
pp. 3749-3786 ◽  
Author(s):  
Francisco Sarabia ◽  
Iván Cheng-Sánchez
Keyword(s):  
Total Synthesis ◽  
Tandem Reactions ◽  
Alkyne Metathesis ◽  
Enyne Metathesis ◽  
Metathesis Reaction ◽  
Ring Closing Metathesis ◽  
Total Syntheses ◽  
Cross Metathesis ◽  
Carbon Carbon Bonds ◽  
Metathesis Reactions

The metathesis reactions, in their various versions, have become a powerful and extremely valuable tool for the formation of carbon–carbon bonds in organic synthesis. The plethora of available catalysts to perform these reactions, combined with the various transformations that can be accomplished, have positioned the metathesis processes as one of the most important reactions of this century. In this review, we highlight the most relevant synthetic contributions published between 2012 and early 2018 in the field of total synthesis, reflecting the state of the art of this chemistry and demonstrating the significant synthetic potential of these methodologies.1 Introduction2 Alkene Metathesis in Total Synthesis2.1 Total Synthesis Based on a Ring-Closing-Metathesis Reaction2.2 Total Synthesis Based on a Cross-Metathesis Reaction2.3 Strategies for Selective and Efficient Metathesis Reactions of Alkenes2.3.1 Temporary Tethered Ring-Closing Metathesis2.3.2 Relay Ring-Closing Metathesis2.3.3 Stereoselective Alkene Metathesis2.3.4 Alkene Metathesis in Tandem Reactions3 Enyne Metathesis in Total Synthesis3.1 Total Syntheses Based on a Ring-Closing Enyne-Metathesis Reaction3.2 Total Syntheses Based on an Enyne Cross-Metathesis Reaction3.3 Enyne Metathesis in Tandem Reactions4 Alkyne Metathesis in Total Synthesis4.1 Total Synthesis Based on a Ring-Closing Alkyne-Metathesis Reaction4.2 Other Types of Alkyne-Metathesis Reactions5 Conclusions

scholarly journals First Total Synthesis of Cryptopyranmoscatone A3 and Crypto­pyranmoscatone B4

SynOpen ◽  
2018 ◽  
Vol 02 (01) ◽  
pp. 0058-0063 ◽  
Author(s):  
A. Reddy ◽  
Gowravaram Sabitha
Keyword(s):  
Total Synthesis ◽  
Michael Addition ◽  
Ring Closing Metathesis ◽  
Cross Metathesis ◽  
Key Steps

The first total synthesis of cryptopyranmoscatones A3 and B4 has been accomplished from d-ribose or but-3-ynol. The key steps involved in the synthesis are oxa-Michael addition, highly diastereo­selective Brown allylation, and ring closing metathesis (RCM) and cross metathesis (CM) reactions.

Concise Total Synthesis of Curvulone B

Synlett ◽  
2020 ◽  
Author(s):  
Debendra K. Mohapatra ◽  
Shivalal Banoth ◽  
Utkal Mani Choudhury ◽  
Kanakaraju Marumudi ◽  
Ajit C. Kunwar
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Ring System ◽  
Bond Forming ◽  
Cross Metathesis ◽  
Bond Forming Reactions ◽  
Key Steps

AbstractA concise and convergent stereoselective synthesis of curvulone B is described. The synthesis utilized a tandem isomerization followed by C–O and C–C bond-forming reactions following Mukaiyama-type aldol conditions for the construction of the trans-2,6-disubstituted dihydropyran ring system as the key steps. Other important features of this synthesis are a cross-metathesis, epimerization, and Friedel–Crafts acylation.

A convergent total synthesis of a new antiepileptic ceramide and its triacetyl derivative using olefin cross metathesis

Tetrahedron ◽  
2010 ◽  
Vol 66 (38) ◽  
pp. 7504-7509 ◽  
Author(s):  
Partha Ghosal ◽  
Vikas Kumar ◽  
Arun K. Shaw
Keyword(s):  
Total Synthesis ◽  
Cross Metathesis

First Stereoselective Total Synthesis of Isoaspinonene through a Baylis-Hillman/Olefin Cross-Metathesis Protocol

2011 ◽  
Vol 2012 (3) ◽  
pp. 616-622 ◽  
Author(s):  
Palakodety Radha Krishna ◽  
Munagala Alivelu ◽  
Tadikamalla Prabhakar Rao
Keyword(s):  
Total Synthesis ◽  
Cross Metathesis

Total Synthesis of the Salicylate Enamide Macrolide Oximidine III: Application of Relay Ring-Closing Metathesis.

ChemInform ◽  
2004 ◽  
Vol 35 (42) ◽  
Author(s):  
Xiang Wang ◽  
Emma Jean Bowman ◽  
Barry J. Bowman ◽  
John A. Jr. Porco
Keyword(s):  
Total Synthesis ◽  
Ring Closing Metathesis
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