Palladium-Catalyzed Asymmetric Hydrogenation of Functionalized Ketones

2005 ◽  
Vol 7 (15) ◽  
pp. 3235-3238 ◽  
Author(s):  
You-Qing Wang ◽  
Sheng-Mei Lu ◽  
Yong-Gui Zhou
Keyword(s):  
Asymmetric Hydrogenation ◽  
Palladium Catalyzed

Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles

2018 ◽  
Vol 5 (19) ◽  
pp. 2805-2809 ◽  
Author(s):  
Chang-Bin Yu ◽  
Jie Wang ◽  
Yong-Gui Zhou
Keyword(s):  
Asymmetric Hydrogenation ◽  
Hydrogenation Process ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Facile Synthesis ◽  
One Pot ◽  
Brönsted Acid ◽  
Palladium Catalyzed ◽  
Intramolecular Condensation

A concise synthesis of chiral indolines has been developed through intramolecular condensation, deprotection and palladium-catalyzed asymmetric hydrogenation in a one-pot process with up to 96% ee. A strong Brønsted acid played an important role in both the formation of indoles and asymmetric hydrogenation process.

Palladium-catalyzed asymmetric hydrogenation of 3-phthalimido substituted quinolines

2014 ◽  
Vol 50 (67) ◽  
pp. 9588-9590 ◽  
Author(s):  
Xian-Feng Cai ◽  
Wen-Xue Huang ◽  
Zhang-Pei Chen ◽  
Yong-Gui Zhou
Keyword(s):  
Asymmetric Hydrogenation ◽  
Substituted Quinolines ◽  
Palladium Catalyzed

Homogeneous Pd-catalyzed asymmetric hydrogenation of 3-phthalimido substituted quinolines was successfully developed with up to 90% ee.

Homogeneous palladium-catalyzed asymmetric hydrogenation

2013 ◽  
Vol 42 (2) ◽  
pp. 497-511 ◽  
Author(s):  
Qing-An Chen ◽  
Zhi-Shi Ye ◽  
Ying Duan ◽  
Yong-Gui Zhou
Keyword(s):  
Asymmetric Hydrogenation ◽  
Palladium Catalyzed

Palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones for the synthesis of trans cycloalkanols through dynamic kinetic resolution under acidic conditions

2020 ◽  
Vol 56 (43) ◽  
pp. 5815-5818 ◽  
Author(s):  
Xiang Li ◽  
Zi-Biao Zhao ◽  
Mu-Wang Chen ◽  
Bo Wu ◽  
Han Wang ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Asymmetric Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Cyclic Ketones ◽  
Palladium Catalyzed ◽  
Acidic Conditions

The first efficient palladium-catalyzed asymmetric hydrogenation of 2-aryl cyclic ketones has been described through dynamic kinetic resolution under acidic conditions, providing a facile access to chiral trans cycloalkanols.

ChemInform Abstract: Palladium-Catalyzed Asymmetric Hydrogenation of Simple Ketones Activated by Broensted Acids.

ChemInform ◽  
2011 ◽  
Vol 42 (37) ◽  
pp. no-no
Author(s):  
Xiao-Yu Zhou ◽  
Duo-Sheng Wang ◽  
Ming Bao ◽  
Yong-Gui Zhou
Keyword(s):  
Asymmetric Hydrogenation ◽  
Palladium Catalyzed

scholarly journals NeoPHOX – a structurally tunable ligand system for asymmetric catalysis

2016 ◽  
Vol 12 ◽  
pp. 1185-1195 ◽  
Author(s):  
Jaroslav Padevět ◽  
Marcus G Schrems ◽  
Robin Scheil ◽  
Andreas Pfaltz
Keyword(s):  
Asymmetric Catalysis ◽  
Asymmetric Hydrogenation ◽  
Tertiary Alcohol ◽  
Allylic Substitution ◽  
Ligand System ◽  
Methoxycarbonyl Group ◽  
Palladium Catalyzed ◽  
Stereogenic Center

A synthesis of new NeoPHOX ligands derived from serine or threonine has been developed. The central intermediate is a NeoPHOX derivative bearing a methoxycarbonyl group at the stereogenic center next to the oxazoline N atom. The addition of methylmagnesium chloride leads to a tertiary alcohol, which can be acylated or silylated to produce NeoPHOX ligands with different sterical demand. The new NeoPHOX ligands were tested in the iridium-catalyzed asymmetric hydrogenation and palladium-catalyzed allylic substitution. In both reactions high enantioselectivities were achieved, that were comparable to the enantioselectivities obtained with the up to now best NeoPHOX ligand derived from expensive tert-leucine.

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