New Synthetic Route for the Enantioselective Total Synthesis of Salinosporamide A and Biologically Active Analogues

2005 ◽  
Vol 7 (13) ◽  
pp. 2699-2701 ◽  
Author(s):  
Leleti Rajender Reddy ◽  
Jean-François Fournier ◽  
B. V. Subba Reddy ◽  
E. J. Corey
Keyword(s):  
Total Synthesis ◽  
Biologically Active ◽  
Synthetic Route ◽  
Enantioselective Total Synthesis ◽  
Salinosporamide A

New Synthetic Route for the Enantioselective Total Synthesis of Salinosporamide A (I) and Biologically Active Analogues.

ChemInform ◽  
2005 ◽  
Vol 36 (45) ◽  
Author(s):  
Leleti Rajender Reddy ◽  
Jean-Francois Fournier ◽  
B. V. Subba Reddy ◽  
E. J. Corey
Keyword(s):  
Total Synthesis ◽  
Biologically Active ◽  
Synthetic Route ◽  
Enantioselective Total Synthesis ◽  
Salinosporamide A

Total Synthesis of (–)-Aristoquinoline via an Intramolecular Nitrilium Ion Cyclization

Synthesis ◽  
2021 ◽  
Author(s):  
Keith P. Reber ◽  
Priyansh D. Gujarati
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Building Block ◽  
Spectroscopic Properties ◽  
Ring System ◽  
Synthetic Route ◽  
Enantioselective Total Synthesis ◽  
Key Steps

AbstractThe enantioselective total synthesis of the alkaloid aristoquinoline has been achieved in seven steps and 26% overall yield. A new preparation of the useful synthetic building block (–)-α-terpinyl amine was also developed in order to avoid stoichiometric mercury reagents or azide-containing intermediates. Key steps in the optimized synthetic route include an intramolecular nitrilium ion cyclization to form the characteristic azabicyclo[3.3.1]nonane ring system and a dia­stereoselective reduction of the resulting imine mixture to afford the natural product. An isomer of aristoquinoline containing an exocyclic alkene was also obtained and found to exhibit unusual chromatographic and spectroscopic properties.

Enantioselective Total Synthesis of (−)-Salinosporamide A (NPI-0052)

2007 ◽  
Vol 9 (12) ◽  
pp. 2289-2292 ◽  
Author(s):  
Taotao Ling ◽  
Venkat R. Macherla ◽  
Rama Rao Manam ◽  
Katherine A. McArthur ◽  
Barbara C. M. Potts
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis ◽  
Salinosporamide A

scholarly journals Enantioselective Total Synthesis of (-)-Salinosporamide A (NPI-0052)

ChemInform ◽  
2007 ◽  
Vol 38 (42) ◽  
Author(s):  
Taotao Ling ◽  
Venkat R. Macherla ◽  
Rama Rao Manam ◽  
Katherine A. McArthur ◽  
Barbara C. M. Potts
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis ◽  
Salinosporamide A

scholarly journals Enantioselective Total Synthesis of (+)‐Garsubellin A

2021 ◽  
Author(s):  
Dongseok Jang ◽  
Minchul Choi ◽  
Jinglong Chen ◽  
Chulbom Lee
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis

Enantioselective Total Synthesis of ( – )‐Spiroxins A, C and D

2021 ◽  
Author(s):  
Xin Shu ◽  
Chong-Chong Chen ◽  
Tao Yu ◽  
Jiayi Yang ◽  
Xiangdong Hu
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis

Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C

2021 ◽  
Vol 67 ◽  
pp. 152895
Author(s):  
Shu Takahashi ◽  
Aoi Kimishima ◽  
Tomoyasu Hirose ◽  
Takeshi Yamada ◽  
Akihiro Sugawara ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Enantioselective Total Synthesis

Enantioselective total synthesis of sesquiterpenoid phellilane L and its diastereomer

Tetrahedron ◽  
2021 ◽  
Vol 87 ◽  
pp. 132110
Author(s):  
Gullapalli Kumaraswamy ◽  
Vankudoth Ramesh ◽  
Swargam Vijaykumar
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis
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