New Synthetic Method for Indole-2-carboxylate and Its Application to the Total Synthesis of Duocarmycin SA

2004 ◽  
Vol 6 (17) ◽  
pp. 2953-2956 ◽  
Author(s):  
Kou Hiroya ◽  
Shigemitsu Matsumoto ◽  
Takao Sakamoto
Keyword(s):  
Total Synthesis ◽  
Synthetic Method ◽  
Duocarmycin Sa

scholarly journals New Synthetic Method for Indole-2-carboxylate and Its Application to the Total Synthesis of Duocarmycin SA.

ChemInform ◽  
2004 ◽  
Vol 35 (50) ◽  
Author(s):  
Kou Hiroya ◽  
Shigemitsu Matsumoto ◽  
Takao Sakamoto
Keyword(s):  
Total Synthesis ◽  
Synthetic Method ◽  
Duocarmycin Sa

scholarly journals Total Synthesis and Evaluation ofiso-Duocarmycin SA andiso-Yatakemycin

2009 ◽  
Vol 131 (3) ◽  
pp. 1187-1194 ◽  
Author(s):  
Karen S. MacMillan ◽  
Trihn Nguyen ◽  
Inkyu Hwang ◽  
Dale L. Boger
Keyword(s):  
Total Synthesis ◽  
Duocarmycin Sa

An Enantioselective Total Synthesis of (+)-Duocarmycin SA

2018 ◽  
Vol 83 (7) ◽  
pp. 3928-3940 ◽  
Author(s):  
Michael A. Schmidt ◽  
Eric M. Simmons ◽  
Carolyn S. Wei ◽  
Hyunsoo Park ◽  
Martin D. Eastgate
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis ◽  
Duocarmycin Sa

A simple synthetic method for chiral 1,2-epoxides and the total synthesis of a chiral pheromone epoxide

2000 ◽  
pp. 53-57 ◽  
Author(s):  
Zhi-Bo Zhang ◽  
Zhi-Min Wang ◽  
Yu-Xiu Wang ◽  
Huan-Quan Liu ◽  
Gui-Xin Lei ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Synthetic Method ◽  
Chiral Pheromone

ChemInform Abstract: Total Synthesis and Preliminary Evaluation of (+)- and ent-(-)- Duocarmycin SA.

ChemInform ◽  
2010 ◽  
Vol 25 (4) ◽  
pp. no-no
Author(s):  
D. L. BOGER ◽  
K. MACHIYA ◽  
D. L. HERTZOG ◽  
P. A. KITOS ◽  
D. HOLMES
Keyword(s):  
Total Synthesis ◽  
Preliminary Evaluation ◽  
Duocarmycin Sa

Total synthesis of (+)-pederine. A simple synthetic method for N-(1-methoxyalkyl)amides

1982 ◽  
Vol 23 (39) ◽  
pp. 4043-4046 ◽  
Author(s):  
Fuyuhiko Matsuda ◽  
Mitsutoshi Yanagiya ◽  
Takeshi Matsumoto
Keyword(s):  
Total Synthesis ◽  
Synthetic Method

Heterocycle synthesis via radical reactions

2008 ◽  
Vol 80 (4) ◽  
pp. 717-726 ◽  
Author(s):  
Takeaki Naito
Keyword(s):  
Total Synthesis ◽  
Heterocyclic Compounds ◽  
Alkyl Radical ◽  
Radical Addition ◽  
Synthetic Method ◽  
Asymmetric Total Synthesis ◽  
Heterocycle Synthesis ◽  
Leaving Group ◽  
Martinellic Acid ◽  
Type Radical

A novel synthetic method for the preparation of nitrogen-containing heterocycles via the route involving domino-type radical addition/cyclization reaction of oxime ethers is described. Alkyl radical addition/cyclization of oxime ethers carrying an appropriate leaving group proceeded smoothly to form the alkylated nitrogen-containing heterocyclic compounds. Additionally, tin-mediated radical addition/cyclization/elimination (RACE) reaction of oxime ethers is newly found and successfully applied to an asymmetric total synthesis of (-)-martinellic acid.

scholarly journals The Pictet-Spengler Reaction Updates Its Habits

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 414 ◽  
Author(s):  
Andrea Calcaterra ◽  
Laura Mangiardi ◽  
Giuliano Delle Monache ◽  
Deborah Quaglio ◽  
Silvia Balducci ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Multicomponent Reaction ◽  
Michael Addition ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Synthetic Method ◽  
Ring Closing Metathesis ◽  
Phase Synthesis ◽  
Acid Catalyzed ◽  
High Yields

The Pictet-Spengler reaction (P-S) is one of the most direct, efficient, and variable synthetic method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), and polyheterocyclic frameworks. In the lustro (five-year period) following its centenary birthday, the P-S reaction did not exit the stage but it came up again on limelight with new features. This review focuses on the interesting results achieved in this period (2011–2015), analyzing the versatility of this reaction. Classic P-S was reported in the total synthesis of complex alkaloids, in combination with chiral catalysts as well as for the generation of libraries of compounds in medicinal chemistry. The P-S has been used also in tandem reactions, with the sequences including ring closing metathesis, isomerization, Michael addition, and Gold- or Brønsted acid-catalyzed N-acyliminium cyclization. Moreover, the combination of P-S reaction with Ugi multicomponent reaction has been exploited for the construction of highly complex polycyclic architectures in few steps and high yields. The P-S reaction has also been successfully employed in solid-phase synthesis, affording products with different structures, including peptidomimetics, synthetic heterocycles, and natural compounds. Finally, the enzymatic version of P-S has been reported for biosynthesis, biotransformations, and bioconjugations.

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