Catalytic Enantioselective Synthesis of Quaternary All-Carbon Stereogenic Centers. Preparation of α,α‘-Disubstituted β,γ-Unsaturated Esters through Cu-Catalyzed Asymmetric Allylic Alkylations

Kerry E. Murphy; Amir H. Hoveyda

doi:10.1021/ol047331r

Catalytic Enantioselective Synthesis of Quaternary All-Carbon Stereogenic Centers. Preparation of α,α‘-Disubstituted β,γ-Unsaturated Esters through Cu-Catalyzed Asymmetric Allylic Alkylations

Organic Letters ◽

10.1021/ol047331r ◽

2005 ◽

Vol 7 (7) ◽

pp. 1255-1258 ◽

Cited By ~ 48

Author(s):

Kerry E. Murphy ◽

Amir H. Hoveyda

Keyword(s):

Enantioselective Synthesis ◽

Unsaturated Esters ◽

Stereogenic Centers ◽

Allylic Alkylations

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Catalytic Enantioselective Synthesis of Quaternary All-Carbon Stereogenic Centers. Preparation of α,α′-Disubstituted β,γ-Unsaturated Esters Through Cu-Catalyzed Asymmetric Allylic Alkylations.

ChemInform ◽

10.1002/chin.200533038 ◽

2005 ◽

Vol 36 (33) ◽

Author(s):

Kerry E. Murphy ◽

Amir H. Hoveyda

Keyword(s):

Enantioselective Synthesis ◽

Unsaturated Esters ◽

Stereogenic Centers ◽

Allylic Alkylations

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Enantioselective Synthesis of α-Alkyl-β,γ-unsaturated Esters through Efficient Cu-Catalyzed Allylic Alkylations

Journal of the American Chemical Society ◽

10.1021/ja0300618 ◽

2003 ◽

Vol 125 (16) ◽

pp. 4690-4691 ◽

Cited By ~ 86

Author(s):

Kerry E. Murphy ◽

Amir H. Hoveyda

Keyword(s):

Enantioselective Synthesis ◽

Unsaturated Esters ◽

Allylic Alkylations

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Assembly of Fluorinated Chromanones via Enantioselective Tandem Reaction

Chemical Communications ◽

10.1039/d1cc01187a ◽

2021 ◽

Author(s):

Mengxue Lu ◽

Zongli Xiong ◽

Yuqiao Zhou ◽

Xin Wang ◽

Xiaoyi Li ◽

...

Keyword(s):

Enantioselective Synthesis ◽

Tandem Reaction ◽

Unsaturated Aldehydes ◽

Stereogenic Centers ◽

First Time

The enantioselective synthesis of fluorinated tricyclic chromanones with multiple vicinal stereogenic centers has been realized for the first time, through the tandem reaction between 2-fluorinated 1-(2-hydroxyaryl)-1,3-diketones and α,β-unsaturated aldehydes. In...

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ChemInform Abstract: The First Asymmetric Carroll Rearrangement Diastereo- and Enantioselective Synthesis of Polyfunctional Ketones with Vicinal Quaternary and Tertiary Stereogenic Centers.

ChemInform ◽

10.1002/chin.199640055 ◽

2010 ◽

Vol 27 (40) ◽

pp. no-no

Author(s):

D. ENDERS ◽

M. KNOPP ◽

J. RUNSINK ◽

G. RAABE

Keyword(s):

Enantioselective Synthesis ◽

Stereogenic Centers

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Enantioselective Synthesis of Alkyne-Substituted Quaternary Carbon Stereogenic Centers through NHC−Cu-Catalyzed Allylic Substitution Reactions with (i-Bu)2(Alkynyl)aluminum Reagents

Journal of the American Chemical Society ◽

10.1021/ja2010829 ◽

2011 ◽

Vol 133 (13) ◽

pp. 4778-4781 ◽

Cited By ~ 105

Author(s):

Jennifer A. Dabrowski ◽

Fang Gao ◽

Amir H. Hoveyda

Keyword(s):

Enantioselective Synthesis ◽

Allylic Substitution ◽

Quaternary Carbon ◽

Substitution Reactions ◽

Stereogenic Centers

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Enantioselective Synthesis of CF3S-Containing Compounds via Ir-Catalyzed Allylic Alkylations of CF3S-Substituted Functionalized Methylene Derivatives

The Journal of Organic Chemistry ◽

10.1021/acs.joc.9b02123 ◽

2019 ◽

Vol 84 (23) ◽

pp. 15648-15654 ◽

Cited By ~ 1

Author(s):

Tao Song ◽

Xiaoming Zhao ◽

Xiaolin Wang

Keyword(s):

Enantioselective Synthesis ◽

Allylic Alkylations

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Enantioselective Synthesis of Quaternary Carbon Stereogenic Centers through Copper-Catalyzed Conjugate Additions of Aryl- and Alkylaluminum Reagents to Acyclic Trisubstituted Enones

Angewandte Chemie International Edition ◽

10.1002/anie.201304035 ◽

2013 ◽

Vol 52 (31) ◽

pp. 8156-8159 ◽

Cited By ~ 46

Author(s):

Jennifer A. Dabrowski ◽

Matthew T. Villaume ◽

Amir H. Hoveyda

Keyword(s):

Enantioselective Synthesis ◽

Quaternary Carbon ◽

Conjugate Additions ◽

Stereogenic Centers

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Organocatalyzed Enantioselective Synthesis of Nitroalkanes Bearing All-Carbon Quaternary Stereogenic Centers through Conjugate Addition of Acetone Cyanohydrin

Synlett ◽

10.1055/s-2008-1078496 ◽

2008 ◽

Vol 2008 (12) ◽

pp. 1857-1861 ◽

Cited By ~ 5

Author(s):

Mariafrancesca Fochi ◽

Alfredo Ricci ◽

Luca Bernardi ◽

Francesco Fini

Keyword(s):

Conjugate Addition ◽

Enantioselective Synthesis ◽

Acetone Cyanohydrin ◽

Stereogenic Centers ◽

Quaternary Stereogenic Centers

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ChemInform Abstract: Diastereofacial Selectivity in Uncatalyzed Diels-Alder Cycloadditions Involving α,β-Unsaturated Esters and Lactones with Stereogenic Centers Containing Oxygen Functionalities.

ChemInform ◽

10.1002/chin.199230046 ◽

2010 ◽

Vol 23 (30) ◽

pp. no-no

Author(s):

R. CASAS ◽

T. PARELLA ◽

V. BRANCHADELL ◽

A. OLIVA ◽

R. M. ORTUNO ◽

...

Keyword(s):

Diels Alder ◽

Unsaturated Esters ◽

Stereogenic Centers

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Recoverable Resin-Supported Pyridylamide Ligand for Microwave-Accelerated Molybdenum-Catalyzed Asymmetric Allylic Alkylations: Enantioselective Synthesis of Baclofen (V).

ChemInform ◽

10.1002/chin.200341092 ◽

2003 ◽

Vol 34 (41) ◽

Author(s):

Oscal Belda ◽

Stina Lundgren ◽

Christina Moberg

Keyword(s):

Enantioselective Synthesis ◽

Allylic Alkylations

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