A Few Molecules Can Control the Enantiomeric Outcome. Evidence Supporting Absolute Asymmetric Synthesis Using the Soai Asymmetric Autocatalysis

2003 ◽  
Vol 5 (23) ◽  
pp. 4337-4339 ◽  
Author(s):  
Daniel A. Singleton ◽  
Loan K. Vo
Keyword(s):  
Asymmetric Synthesis ◽  
Absolute Asymmetric Synthesis ◽  
Asymmetric Autocatalysis

Spontaneous absolute asymmetric synthesis in the presence of achiral silica gel in conjunction with asymmetric autocatalysis

Chirality ◽  
2006 ◽  
Vol 18 (7) ◽  
pp. 479-482 ◽  
Author(s):  
Tsuneomi Kawasaki ◽  
Kenta Suzuki ◽  
Masako Shimizu ◽  
Keisuke Ishikawa ◽  
Kenso Soai
Keyword(s):  
Asymmetric Synthesis ◽  
Silica Gel ◽  
Absolute Asymmetric Synthesis ◽  
Asymmetric Autocatalysis

scholarly journals Formation of enantioenriched alkanol with stochastic distribution of enantiomers in the absolute asymmetric synthesis under heterogeneous solid–vapor phase conditions

2019 ◽  
Vol 55 (36) ◽  
pp. 5223-5226 ◽  
Author(s):  
Yoshiyasu Kaimori ◽  
Yui Hiyoshi ◽  
Tsuneomi Kawasaki ◽  
Arimasa Matsumoto ◽  
Kenso Soai
Keyword(s):  
Asymmetric Synthesis ◽  
Vapor Phase ◽  
Absolute Asymmetric Synthesis ◽  
Asymmetric Autocatalysis ◽  
The Absolute ◽  
Stochastic Distribution ◽  
Heterogeneous Solid

Absolute asymmetric synthesis under heterogeneous solid–vapor phase conditions in conjunction with asymmetric autocatalysis was achieved.

Absolute Asymmetric Synthesis: A Commentary

2003 ◽  
Vol 68 (5) ◽  
pp. 849-864 ◽  
Author(s):  
Kurt Mislow
Keyword(s):  
Asymmetric Synthesis ◽  
Enantiomeric Excess ◽  
Optically Active ◽  
Random Chance ◽  
Chemical Reagents ◽  
Absolute Asymmetric Synthesis ◽  
Asymmetric Autocatalysis ◽  
Physical Forces ◽  
Biomolecular Homochirality ◽  
The Difference

Absolute asymmetric synthesis, i.e., the formation of enantiomerically enriched products from achiral precursors without the intervention of chiral chemical reagents or catalysts, is in practice unavoidable on statistical grounds alone. That random chance, combined with suitable amplification mechanisms, might ultimately account for biomolecular homochirality in Nature was recognized more than a century ago. Soai and collaborators have recently developed an asymmetric autocatalysis reaction that is capable of amplifying a tiny enantiomeric excess of far below 1% to yield a nearly enantiopure product. Although there is no easy way to tell the difference between an asymmetric autocatalysis reaction initiated by the tiny enantiomeric excess due to random chance and one initiated by minuscule quantities of unidentified chiral impurities, it is nevertheless all but certain that the Soai reaction is capable of producing optically active compounds by an absolute asymmetric synthesis, starting from nominally achiral reagents free of chiral contaminants and run under achiral conditions, e.g., without the intervention of chiral physical forces.

scholarly journals Spontaneous absolute asymmetric synthesis promoted by achiral amines in conjunction with asymmetric autocatalysis

2010 ◽  
Vol 1 (1) ◽  
pp. 5 ◽  
Author(s):  
Kenta Suzuki ◽  
Kunihiko Hatase ◽  
Daisuke Nishiyama ◽  
Tsuneomi Kawasaki ◽  
Kenso Soai
Keyword(s):  
Asymmetric Synthesis ◽  
Absolute Asymmetric Synthesis ◽  
Asymmetric Autocatalysis

Absolute Asymmetric Synthesis of Tertiary α-Amino Acids

2012 ◽  
Vol 124 (20) ◽  
pp. 5065-5068 ◽  
Author(s):  
Thi Thoa Mai ◽  
Mathieu Branca ◽  
Didier Gori ◽  
Régis Guillot ◽  
Cyrille Kouklovsky ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Absolute Asymmetric Synthesis
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