Concise Total Synthesis of (+)-Brefeldin A:  A Combined β-Lactone/Cross-Metathesis-Based Strategy

2002 ◽  
Vol 4 (19) ◽  
pp. 3231-3234 ◽  
Author(s):  
Yingcai Wang ◽  
Daniel Romo
Keyword(s):  
Total Synthesis ◽  
Brefeldin A ◽  
Cross Metathesis

Concise Total Synthesis of Curvulone B

Synlett ◽  
2020 ◽  
Author(s):  
Debendra K. Mohapatra ◽  
Shivalal Banoth ◽  
Utkal Mani Choudhury ◽  
Kanakaraju Marumudi ◽  
Ajit C. Kunwar
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Ring System ◽  
Bond Forming ◽  
Cross Metathesis ◽  
Bond Forming Reactions ◽  
Key Steps

AbstractA concise and convergent stereoselective synthesis of curvulone B is described. The synthesis utilized a tandem isomerization followed by C–O and C–C bond-forming reactions following Mukaiyama-type aldol conditions for the construction of the trans-2,6-disubstituted dihydropyran ring system as the key steps. Other important features of this synthesis are a cross-metathesis, epimerization, and Friedel–Crafts acylation.

A convergent total synthesis of a new antiepileptic ceramide and its triacetyl derivative using olefin cross metathesis

Tetrahedron ◽  
2010 ◽  
Vol 66 (38) ◽  
pp. 7504-7509 ◽  
Author(s):  
Partha Ghosal ◽  
Vikas Kumar ◽  
Arun K. Shaw
Keyword(s):  
Total Synthesis ◽  
Cross Metathesis

First Stereoselective Total Synthesis of Isoaspinonene through a Baylis-Hillman/Olefin Cross-Metathesis Protocol

2011 ◽  
Vol 2012 (3) ◽  
pp. 616-622 ◽  
Author(s):  
Palakodety Radha Krishna ◽  
Munagala Alivelu ◽  
Tadikamalla Prabhakar Rao
Keyword(s):  
Total Synthesis ◽  
Cross Metathesis

Total Synthesis of 5-Hydroxygoniothalamin

Synthesis ◽  
2018 ◽  
Vol 51 (03) ◽  
pp. 780-786 ◽  
Author(s):  
Srinivas Kantevari ◽  
Santhosh Patpi ◽  
Guangyi Jin
Keyword(s):  
Total Synthesis ◽  
Good Yield ◽  
Cross Metathesis

The total synthesis of 5-hydroxygoniothalamin is achieved from commercially available l-xylose. The α,β-unsaturated-δ-lactone core is constructed in very good yield by utilizing one-carbon and two-carbon cis-Wittig olefinations and δ-lactonization using Yamaguchi conditions. Subsequent Grubbs cross-metathesis followed by desilylation results in 5-hydroxygoniothalamin.

Enantioselective Total Synthesis of (+)-Brefeldin A and 7-epi-Brefeldin A

2004 ◽  
Vol 69 (11) ◽  
pp. 3857-3865 ◽  
Author(s):  
Yikang Wu ◽  
Xin Shen ◽  
Yong-Qing Yang ◽  
Qi Hu ◽  
Jia-Hui Huang
Keyword(s):  
Total Synthesis ◽  
Brefeldin A ◽  
Enantioselective Total Synthesis

Synthesis of an analog of mycothiazole and total synthesis of pseudotrienic acid B

2007 ◽  
Vol 79 (4) ◽  
pp. 677-684 ◽  
Author(s):  
Dominique Amans ◽  
Alexandre Le Flohic ◽  
Véronique Bellosta ◽  
Christophe Meyer ◽  
Janine Cossy
Keyword(s):  
Total Synthesis ◽  
Ring Closing Metathesis ◽  
Cross Metathesis

An analog of mycothiazole and pseudotrienic acid B were synthesized efficiently by using ring-closing metathesis or cross-metathesis as key reactions.

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