Synthesis ofO-Glycolyl-Linked Neuraminic Acids through a Spirocyclic Intermediate

2002 ◽  
Vol 4 (18) ◽  
pp. 3067-3069 ◽  
Author(s):  
Joseph C. McAuliffe ◽  
David Rabuka ◽  
Ole Hindsgaul
Keyword(s):  
Neuraminic Acids

scholarly journals Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS

2020 ◽  
Vol 7 (2) ◽  
pp. e676 ◽  
Author(s):  
Kayluz F. Boligan ◽  
Johanna Oechtering ◽  
Christian W. Keller ◽  
Benjamin Peschke ◽  
Robert Rieben ◽  
...  
Keyword(s):  
Igg Antibodies ◽  
Glycan Array ◽  
Neurologic Diseases ◽  
Acetylneuraminic Acid ◽  
Neuraminic Acids ◽  
Relapsing Remitting ◽  
Specific Immunoglobulin ◽  
Treatment Naïve ◽  
Relapsing Remitting Multiple Sclerosis ◽  
Unique Signature

ObjectiveTo explore the repertoire of glycan-specific immunoglobulin G (IgG) antibodies in treatment-naive patients with relapsing-remitting multiple sclerosis (RRMS).MethodsA systems-level approach combined with glycan array technologies was used to determine specificities and binding reactivities of glycan-specific IgGs in treatment-naive patients with RRMS compared with patients with noninflammatory and other inflammatory neurologic diseases.ResultsWe identified a unique signature of glycan-binding IgG in MS with high reactivities to the dietary xenoglycan N-glycolylneuraminic acid (Neu5Gc) and the self-glycan N-acetylneuraminic acid (Neu5Ac). Increased reactivities of serum IgG toward Neu5Gc and Neu5Ac were additionally observed in an independent, treatment-naive cohort of patients with RRMS.ConclusionPatients with MS show increased IgG reactivities to structurally related xenogeneic and human neuraminic acids. The discovery of these glycan-specific epitopes as immune targets and potential biomarkers in MS merits further investigation.

scholarly journals ERRATUM

1964 ◽  
Vol 12 (8) ◽  
pp. 646-646
Keyword(s):  
Letter To The Editor ◽  
Neuraminic Acids ◽  
Histochemical Identification

In the Letter to the Editor from Dr. Carlo Ravetto entitled "Histochemical Identification of Sialic (Neuraminic) Acids", which appeared in the April issue of this JOURNAL (12:306, 1964), the author's name was given as Ravetto Carlo. Index and abstract journals please note especially. The JOURNAL regrets this error.

Synthesis ofN-Acetyl-3-fluoro-neuraminic Acids

1988 ◽  
Vol 52 (5) ◽  
pp. 1209-1215 ◽  
Author(s):  
Tatsuo Nakajima ◽  
Hiroshi Hori ◽  
Hiroshi Ohrui ◽  
Hiroshi Meguro ◽  
Tatsuo Ido
Keyword(s):  
Neuraminic Acids

The Chemistry of Neuraminic Acids. I. The Ehrlich Reaction1

1962 ◽  
Vol 27 (10) ◽  
pp. 3696-3697 ◽  
Author(s):  
L. R. Morgan ◽  
R. Schunior
Keyword(s):  
Neuraminic Acids

ChemInform Abstract: Synthesis of Methyl 4-Acetamido-N-acetyl-4-deoxy-α- and β-4- epi-neuraminic Acids.

ChemInform ◽  
2010 ◽  
Vol 27 (9) ◽  
pp. no-no
Author(s):  
B. P. BANDGAR ◽  
S. V. PATIL ◽  
E. ZBIRAL
Keyword(s):  
Neuraminic Acids

scholarly journals Anti–SARS-CoV-2 Natural Products as Potentially Therapeutic Agents

2021 ◽  
Vol 12 ◽  
Author(s):  
Cheorl-Ho Kim
Keyword(s):  
Natural Products ◽  
Large Scale ◽  
Vaccine Development ◽  
Computational Simulation ◽  
Antiviral Agent ◽  
Host Cells ◽  
Inhibitory Compounds ◽  
Neuraminic Acids ◽  
Relationship Of ◽  
Plant Sources

Severe acute respiratory syndrome–related coronavirus-2 (SARS-CoV-2), a β-coronavirus, is the cause of the recently emerged pandemic and worldwide outbreak of respiratory disease. Researchers exchange information on COVID-19 to enable collaborative searches. Although there is as yet no effective antiviral agent, like tamiflu against influenza, to block SARS-CoV-2 infection to its host cells, various candidates to mitigate or treat the disease are currently being investigated. Several drugs are being screened for the ability to block virus entry on cell surfaces and/or block intracellular replication in host cells. Vaccine development is being pursued, invoking a better elucidation of the life cycle of the virus. SARS-CoV-2 recognizes O-acetylated neuraminic acids and also several membrane proteins, such as ACE2, as the result of evolutionary switches of O-Ac SA recognition specificities. To provide information related to the current development of possible anti–SARS-COV-2 viral agents, the current review deals with the known inhibitory compounds with low molecular weight. The molecules are mainly derived from natural products of plant sources by screening or chemical synthesis via molecular simulations. Artificial intelligence–based computational simulation for drug designation and large-scale inhibitor screening have recently been performed. Structure–activity relationship of the anti–SARS-CoV-2 natural compounds is discussed.

Preparation and fractionation of goat κ-casein: analysis of the glycan and peptide components

1978 ◽  
Vol 45 (2) ◽  
pp. 191-196 ◽  
Author(s):  
Francesco Addeo ◽  
Solange Soulier ◽  
Jean-Pierre Pelissier ◽  
Jean-Marc Chobert ◽  
Jean-Claude Mercier ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Amino Acid ◽  
Amino Acid Composition ◽  
Acid Composition ◽  
Deae Cellulose ◽  
Phosphate Content ◽  
Carbohydrate Composition ◽  
Neuraminic Acids ◽  
Main Fraction ◽  
Carbohydrate Contents

SummaryWhole goat κ-casein was prepared by chromatography of whole casein on hydroxyapatite. Chromatography of whole κ-casein on DEAE-cellulose separated 5 fractions. All of them were sensitive to chymosin. Their amino acid and carbohydrate composition, phosphate content and molecular weight were determined. Galactose, N-acetylgalactosamine, N-acetyl and N-glycolyl neuraminic acids were identified in whole κ-casein. It appears that goat κ-casein, like cow, buffalo and ewe κ-caseins, is composed of several fractions having identical peptide chains and differing in their carbohydrate contents. The main fraction, devoid of carbohydrate, was treated with chymosin. The para-κ-casein and caseinomacropeptide were isolated. Their amino acid composition and phosphate content were determined.

Gas-liquid chromatography of N- and O-acylated neuraminic acids

1975 ◽  
Vol 65 (1-2) ◽  
pp. 507-524 ◽  
Author(s):  
Jorge Casals-Stenzel ◽  
Hans-Peter Buscher ◽  
Roland Schauer
Keyword(s):  
Liquid Chromatography ◽  
Gas Liquid Chromatography ◽  
Neuraminic Acids
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