Synthesis ofN-(3-Arylpropyl)amino Acid Derivatives by Sonogashira Types of Reaction in Aqueous Media†

2001 ◽  
Vol 3 (18) ◽  
pp. 2823-2826 ◽  
Author(s):  
M. Pilar López-Deber ◽  
Luis Castedo ◽  
Juan R. Granja
Keyword(s):  
Amino Acid ◽  
Aqueous Media ◽  
Amino Acid Derivatives

scholarly journals Application of Polyamines and Amino Acid Derivatives Based on 2-Azabicycloalkane Backbone in Enantioselective Aldol Reaction

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5166
Author(s):  
Dominika Iwan ◽  
Karolina Kamińska ◽  
Elżbieta Wojaczyńska
Keyword(s):  
Catalytic Activity ◽  
Amino Acid ◽  
Aldol Reaction ◽  
Aqueous Media ◽  
Amino Acid Derivatives ◽  
Carbon Bond ◽  
Bond Forming ◽  
Backbone Amide ◽  
Carbon Carbon Bond ◽  
Excellent Chemical

Carbon–carbon bond forming reactions, such as aldol reaction and condensation, belong to extremely desired transformations as manifested by >25,000 entries in SciFinder. Their stereoselective variant requires the use of an appropriate catalyst with a strictly defined structure. Hence, chiral 2-azabicycloalkane-based catalysts were designed, synthesized and tested in a stereoselective aldol reaction between cyclic/acyclic ketone and p-nitrobenzaldehyde both in organic and aqueous media. Among catalysts containing a chiral bicyclic backbone, amide based on 2-azabicyclo[3.2.1]octane and pyrrolidine units showed the best catalytic activity and afforded aldol product in excellent chemical yields (up to 95%) and good diastereo- and enantioselectivity (dr 22:78, ee up to 63%).

ChemInform Abstract: Synthesis of N-(3-Arylpropyl)amino Acid Derivatives by Sonogashira Types of Reaction in Aqueous Media.

ChemInform ◽  
2010 ◽  
Vol 33 (2) ◽  
pp. no-no
Author(s):  
M. Pilar Lopez-Deber ◽  
Luis Castedo ◽  
Juan R. Granja
Keyword(s):  
Amino Acid ◽  
Aqueous Media ◽  
Amino Acid Derivatives

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

scholarly journals In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide

2019 ◽  
Vol 34 (1) ◽  
pp. 1247-1258 ◽  
Author(s):  
Asmaa F. Kassem ◽  
Gaber O. Moustafa ◽  
Eman S. Nossier ◽  
Hemat S. Khalaf ◽  
Marwa M. Mounier ◽  
...  
Keyword(s):  
Amino Acid ◽  
Molecular Modelling ◽  
Amino Acid Derivatives ◽  
Modelling Study

scholarly journals Synthesis and antimicrobial activity of some novel 1,2-dihydro-[1,2,4]triazolo[1,5-a]pyrimidines bearing amino acid moiety

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2905-2916
Author(s):  
Mounir A. A. Mohamed ◽  
Adnan A. Bekhit ◽  
Omyma A. Abd Allah ◽  
Asmaa M. Kadry ◽  
Tamer M. Ibrahim ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Green Chemistry ◽  
Antimicrobial Activities ◽  
Amino Acid Derivatives ◽  
Acid Moiety ◽  
Amino Acid Moiety

A new series of [1,2,4]-triazole bearing amino acid derivatives were synthesized under green chemistry conditions and evaluated for their antimicrobial activities.

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