Stereoselective Synthesis of Substituted γ-Butyrolactones by the [3 + 2] Annulation of Allylic Silanes with Chlorosulfonyl Isocyanate:  Enantioselective Total Synthesis of (+)-Blastmycinone

2001 ◽  
Vol 3 (5) ◽  
pp. 675-678 ◽  
Author(s):  
Zhi-Hui Peng ◽  
K. A. Woerpel
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Enantioselective Total Synthesis ◽  
Allylic Silanes ◽  
Chlorosulfonyl Isocyanate

scholarly journals Enantioselective Total Synthesis of the Archaeal Lipid Parallel GDGT-0

2021 ◽  
Author(s):  
Isaac D. Falk ◽  
Bálint Gál ◽  
Ahanjit Bhattacharya ◽  
Jeremy H. Wei ◽  
Paula V. Welander ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Self Assembly ◽  
Stereoselective Synthesis ◽  
Membrane Lipids ◽  
Biophysical Properties ◽  
Limited Access ◽  
Enantioselective Total Synthesis ◽  
Polar Groups ◽  
Tetraether Lipid ◽  
Significant Interest

Archaeal glycerol dibiphytanyl glycerol tetraethers (GDGT) are some of the most unusual membrane lipids identified in nature. These amphiphiles are the major constituents of the membranes of numerous <i>Archaea</i>, some of which are extremophilic organisms. Due to their unique structures, there has been significant interest in studying both the biophysical properties and the biosynthesis of these molecules. However, these studies have thus far been hampered by limited access to chemically pure samples. Herein, we report a concise and stereoselective synthesis of the archaeal tetraether lipid GDGT-0 and the synthesis and self-assembly of derivatives bearing different polar groups.

scholarly journals Enantioselective Total Synthesis of the Archaeal Lipid Parallel GDGT-0

2021 ◽  
Author(s):  
Isaac D. Falk ◽  
Bálint Gál ◽  
Ahanjit Bhattacharya ◽  
Jeremy H. Wei ◽  
Paula V. Welander ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Self Assembly ◽  
Stereoselective Synthesis ◽  
Membrane Lipids ◽  
Biophysical Properties ◽  
Limited Access ◽  
Enantioselective Total Synthesis ◽  
Polar Groups ◽  
Tetraether Lipid ◽  
Significant Interest

Archaeal glycerol dibiphytanyl glycerol tetraethers (GDGT) are some of the most unusual membrane lipids identified in nature. These amphiphiles are the major constituents of the membranes of numerous <i>Archaea</i>, some of which are extremophilic organisms. Due to their unique structures, there has been significant interest in studying both the biophysical properties and the biosynthesis of these molecules. However, these studies have thus far been hampered by limited access to chemically pure samples. Herein, we report a concise and stereoselective synthesis of the archaeal tetraether lipid GDGT-0 and the synthesis and self-assembly of derivatives bearing different polar groups.

scholarly journals Enantioselective Total Synthesis of the Archaeal Lipid Parallel GDGT-0

2021 ◽  
Author(s):  
Isaac D. Falk ◽  
Bálint Gál ◽  
Ahanjit Bhattacharya ◽  
Jeremy H. Wei ◽  
Paula V. Welander ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Self Assembly ◽  
Stereoselective Synthesis ◽  
Membrane Lipids ◽  
Biophysical Properties ◽  
Limited Access ◽  
Enantioselective Total Synthesis ◽  
Polar Groups ◽  
Tetraether Lipid ◽  
Significant Interest

Archaeal glycerol dibiphytanyl glycerol tetraethers (GDGT) are some of the most unusual membrane lipids identified in nature. These amphiphiles are the major constituents of the membranes of numerous <i>Archaea</i>, some of which are extremophilic organisms. Due to their unique structures, there has been significant interest in studying both the biophysical properties and the biosynthesis of these molecules. However, these studies have thus far been hampered by limited access to chemically pure samples. Herein, we report a concise and stereoselective synthesis of the archaeal tetraether lipid GDGT-0 and the synthesis and self-assembly of derivatives bearing different polar groups.

Concise Total Synthesis of Curvulone B

Synlett ◽  
2020 ◽  
Author(s):  
Debendra K. Mohapatra ◽  
Shivalal Banoth ◽  
Utkal Mani Choudhury ◽  
Kanakaraju Marumudi ◽  
Ajit C. Kunwar
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Ring System ◽  
Bond Forming ◽  
Cross Metathesis ◽  
Bond Forming Reactions ◽  
Key Steps

AbstractA concise and convergent stereoselective synthesis of curvulone B is described. The synthesis utilized a tandem isomerization followed by C–O and C–C bond-forming reactions following Mukaiyama-type aldol conditions for the construction of the trans-2,6-disubstituted dihydropyran ring system as the key steps. Other important features of this synthesis are a cross-metathesis, epimerization, and Friedel–Crafts acylation.

scholarly journals Enantioselective Total Synthesis of (+)‐Garsubellin A

2021 ◽  
Author(s):  
Dongseok Jang ◽  
Minchul Choi ◽  
Jinglong Chen ◽  
Chulbom Lee
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis

Enantioselective Total Synthesis of ( – )‐Spiroxins A, C and D

2021 ◽  
Author(s):  
Xin Shu ◽  
Chong-Chong Chen ◽  
Tao Yu ◽  
Jiayi Yang ◽  
Xiangdong Hu
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis

Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C

2021 ◽  
Vol 67 ◽  
pp. 152895
Author(s):  
Shu Takahashi ◽  
Aoi Kimishima ◽  
Tomoyasu Hirose ◽  
Takeshi Yamada ◽  
Akihiro Sugawara ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Enantioselective Total Synthesis
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