Sulfinimine-Mediated Asymmetric Synthesis of 1,3-Disubstituted Tetrahydroisoquinolines:  A Stereoselective Synthesis ofcis- andtrans-6,8-Dimethoxy-1,3-dimethyl- 1,2,3,4-tetrahydroisoquinoline

2000 ◽  
Vol 2 (24) ◽  
pp. 3901-3903 ◽  
Author(s):  
Franklin A. Davis ◽  
Pradyumna K. Mohanty ◽  
David M. Burns ◽  
Yemane W. Andemichael
Keyword(s):  
Asymmetric Synthesis ◽  
Stereoselective Synthesis

scholarly journals Chiral Thioureas—Preparation and Significance in Asymmetric Synthesis and Medicinal Chemistry

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 401 ◽  
Author(s):  
Franz Steppeler ◽  
Dominika Iwan ◽  
Elżbieta Wojaczyńska ◽  
Jacek Wojaczyński
Keyword(s):  
Hydrogen Bond ◽  
Drug Development ◽  
Asymmetric Synthesis ◽  
Stereoselective Synthesis ◽  
Strong Hydrogen Bond ◽  
Hydrogen Bond Donor ◽  
Drug Candidates ◽  
Current State ◽  
The Family ◽  
Donor Capability

For almost 20 years, thioureas have been experiencing a renaissance of interest with the emerged development of asymmetric organocatalysts. Due to their relatively high acidity and strong hydrogen bond donor capability, they differ significantly from ureas and offer, appropriately modified, great potential as organocatalysts, chelators, drug candidates, etc. The review focuses on the family of chiral thioureas, presenting an overview of the current state of knowledge on their synthesis and selected applications in stereoselective synthesis and drug development.

A Highly Stereoselective Synthesis of Glycidic Amides Based on a New Class of Chiral Sulfonium Salts: Applications in Asymmetric Synthesis

2012 ◽  
Vol 18 (47) ◽  
pp. 15190-15201 ◽  
Author(s):  
Francisco Sarabia ◽  
Carlos Vivar-García ◽  
Miguel García-Castro ◽  
Cristina García-Ruiz ◽  
Francisca Martín-Gálvez ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Stereoselective Synthesis ◽  
Sulfonium Salts ◽  
New Class

scholarly journals P(III) vs. P(V): A P(V) Reagent for Thiophosphoramidate Linkages and Application to An Asymmetric Synthesis of a Cyclic Dinucleotide STING Agonist

2021 ◽  
Author(s):  
Bin Zheng ◽  
Chao Hang ◽  
Jason Zhu ◽  
Geoffrey Purdum ◽  
Melda Sezen-Edmonds ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Functional Groups ◽  
Stereoselective Synthesis ◽  
Key Functional Groups ◽  
First Time ◽  
Cyclic Dinucleotide

A highly stereoselective synthesis of a cyclic dinucleotide (CDN) STING agonist containing two chiral thiophosphoramidate linkages is described. These rare, yet key functional groups were, for the first time, installed efficiently and with high diastereoselectivity using a specially designed P(V) reagent. By utilizing this strategy, the CDN was prepared in greater than sixteen-fold higher yield than the prior P(III) approach, with fewer hazardous reagents and chromatographic purifications.

ChemInform Abstract: A Highly Stereoselective Synthesis of Glycidic Amides Based on a New Class of Chiral Sulfonium Salts: Applications in Asymmetric Synthesis.

ChemInform ◽  
2013 ◽  
Vol 44 (16) ◽  
pp. no-no
Author(s):  
Francisco Sarabia ◽  
Carlos Vivar-Garcia ◽  
Miguel Garcia-Castro ◽  
Cristina Garcia-Ruiz ◽  
Francisca Martin-Galvez ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Stereoselective Synthesis ◽  
Sulfonium Salts ◽  
New Class
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