1,4-Hydrogen Radical Transfer as a New and Versatile Tool for the Synthesis of Enantiomerically Pure 1,2,3-Triols

2000 ◽  
Vol 2 (17) ◽  
pp. 2591-2594 ◽  
Author(s):  
Mihaela Gulea ◽  
Juan Manuel López-Romero ◽  
Louis Fensterbank ◽  
Max Malacria
Keyword(s):  
Enantiomerically Pure ◽  
Versatile Tool ◽  
Radical Transfer ◽  
Hydrogen Radical

ChemInform Abstract: 1,4-Hydrogen Radical Transfer as a New and Versatile Tool for the Synthesis of Enantiomerically Pure 1,2,3-Triols.

ChemInform ◽  
2000 ◽  
Vol 31 (47) ◽  
pp. no-no
Author(s):  
Mihaela Gulea ◽  
Juan Manuel Lopez-Romero ◽  
Louis Fensterbank ◽  
Max Malacria
Keyword(s):  
Enantiomerically Pure ◽  
Versatile Tool ◽  
Radical Transfer ◽  
Hydrogen Radical

scholarly journals Hydrogen radical-shuttle (HRS)-enabled photoredox synthesis of indanones via decarboxylative annulation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Bo Yang ◽  
Shi-Jun Li ◽  
Yongdong Wang ◽  
Yu Lan ◽  
Shifa Zhu
Keyword(s):  
Organic Synthesis ◽  
Carbonyl Compounds ◽  
Density Functional ◽  
Functional Group ◽  
Hydrogen Atom Transfer ◽  
Effective Strategy ◽  
Functional Theory ◽  
Slow Kinetics ◽  
Radical Transfer ◽  
Hydrogen Radical

AbstractHydrogen atom transfer (HAT) process is a powerful and effective strategy for activating C-H bonds followed by further functionalization. Intramolecular 1,n (n = 5 or 6)-HATs are common and frequently encountered in organic synthesis. However, intramolecular 1,n (n = 2 or 3)-HAT is very challenging due to slow kinetics. Compared to proton-shuttle process, which is well established for organic synthesis, hydrogen radical-shuttle (HRS) is unexplored. In this work, a HRS-enabled decarboxylative annulation of carbonyl compounds via photoredox catalysis for the synthesis of indanones is developed. This protocol features broad substrate scope, excellent functional group tolerance, internal hydrogen radical transfer, atom- and step-economy. Critical to the success of this process is the introduction of water, acting as both HRS and hydrogen source, which was demonstrated by mechanistic experiments and density functional theory (DFT) calculations. Importantly, this mechanistically distinctive HAT provides a complement to that of typical proton-shuttle-promoted, representing a breakthrough in hydrogen radical transfer, especially in the inherently challenging 1,2- or 1,3-HAT.

scholarly journals Hydride Transfer versus Hydrogen Radical Transfer in Thymidylate Synthase

2006 ◽  
Vol 128 (17) ◽  
pp. 5636-5637 ◽  
Author(s):  
Baoyu Hong ◽  
Majd Haddad ◽  
Frank Maley ◽  
Jan H. Jensen ◽  
Amnon Kohen
Keyword(s):  
Thymidylate Synthase ◽  
Hydride Transfer ◽  
Radical Transfer ◽  
Hydrogen Radical

Enzymatic Synthesis of Enantiomerically Pure Chiral Synthons: Lipase-Catalyzed Resolution of (R/S, 4E)-2-Methyl-4-hexen-l-ol

Synlett ◽  
1991 ◽  
Vol 1991 (04) ◽  
pp. 310-312
Author(s):  
Patrizia Ferraboschi ◽  
Daria Brembilla ◽  
Paride Grisenti ◽  
Enzo Santaniello
Keyword(s):  
Enzymatic Synthesis ◽  
Enantiomerically Pure

CRUCIBLE S7

Alloy Digest ◽  
1996 ◽  
Vol 45 (7) ◽  
Keyword(s):  
Heat Treatment ◽  
Fracture Toughness ◽  
Physical Properties ◽  
Tool Steel ◽  
Cold Work ◽  
Heat Treating ◽  
High Shock ◽  
Unusual Combination ◽  
Versatile Tool ◽  
Shock Resistance

Abstract Crucible S7 is a chromium/molybdenum tool steel developed to produce the unusual combination of high shock resistance and toughness together with ease of machining and heat treatment. It is a versatile tool steel applicable for both hot and cold work shock applications. This datasheet provides information on composition, physical properties, hardness, and elasticity as well as fracture toughness. It also includes information on heat treating, machining, and joining. Filing Code: TS-543. Producer or source: Crucible Service Centers.

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