Volume 1. Polyketides and Other Secondary Metabolites Including Fatty Acids and Their Derivatives Edited by Ushio Sankawa (Toyama Medical and Pharmaceutical University, Japan). xl + 1007 pp.

2000 ◽  
Vol 63 (2) ◽  
pp. 287-288
Author(s):  
A. Douglas Kinghorn
Keyword(s):  
Fatty Acids ◽  
Secondary Metabolites ◽  
Toyama Medical

Obtaining and Characterization of Alhagi persarum Boiss. et Buhse Callus Cell Cultures, Isoflavonoid Producers

2020 ◽  
Vol 36 (6) ◽  
pp. 35-48
Author(s):  
D.V. Коchkin ◽  
G.I. Sobolkovа ◽  
А.А. Fоmеnkov ◽  
R.А. Sidorov ◽  
А.М. Nоsоv
Keyword(s):  
Fatty Acids ◽  
Cell Culture ◽  
Liquid Chromatography ◽  
Secondary Metabolites ◽  
Cell Cultures ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection ◽  
Gas Liquid Chromatography ◽  
Callus Cell

The physiological characteristics of the callus cell cultures of Alhagi persarum Boiss et Buhse, a member of the legume family, widely used in folk medicine, have been studied. It was shown that the source of the explant was an important factor in the initiation of callusogenesis: more intense callusogenesis (almost 100%) was observed for explants from various organs of sterile seedlings, rather than intact plants (less than 30%). As a result, more than 20 lines of morphologically different callus cell cultures were obtained, and the growth parameters for the 5 most intensively growing lines were determined. The composition of fatty acids (FA) of total lipids and secondary metabolites in the most physiologically stable callus line Aр-207 was analyzed. Using capillary gas-liquid chromatography with mass spectrometric detection (GLC-MS), 19 individual C12--C24 FAs were identified, the main fraction of which were palmitic (~ 23%), stearic (~ 22%), linoleic (~ 14%) and α-linolenic (~ 33%) acids. The established atypical ratio of FAs (a simultaneous high content of both saturated FAs and polyunsaturated α-linolenic acid) is possibly due to the adaptation of cells to in vitro growth conditions. Phytochemical analysis of the secondary metabolites was carried out using ultra-performance liquid chromatography with electrospray ionization mass spectrometric detection (UPLC MS). Compounds belonging to different structural groups of isoflavones were found. Aglycones (calycosin, formononetin and afrormosin isomer), glucosides (formononetin glucoside), as well as esters of glucosides (malonylglycosides of calicosin, formononetin, afrormosin isomers, glycitein and genistein) were detected. These secondary metabolites are widespread in plants of the Fabaceae family; however, isoflavones are rare in representatives of the Alhagi genus. The presence of malonylated isoflavone glycosides in Alhagi spp. was shown for the first time. endemic plant species, Alhagi, in vitro cell culture, callus cell culture, isoflavones, fatty acids All studies were carried out using the equipment of the "Experimental Biotechnological Facility" and the "All-Russian Collection of Cell Cultures of Higher Plants" of IРР RAS. This work was supported by the Russian Foundation for Basic Research (RFBR), contract no.18-54-06021 (Az_a), and the Government of the Russian Federation, Megagrant Project no. 075-15-2019-1882.

scholarly journals QUANTITATIVE ANALYSIS OF BIOACTIVE COMPOUNDS OF ARTEMISIA NILAGIRICA (CLARKE) PAMP. LEAF EXTRACT

2016 ◽  
pp. 183
Author(s):  
Parameswari P ◽  
Devika Rengaswamy
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Quantitative Analysis ◽  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Leaf Extract ◽  
Metabolic Reaction ◽  
Quantitative Investigation ◽  
Artemisia Nilagirica ◽  
Quantitative Examination

<p>ABSTRACT<br />Objective: The points of this exploration work were to decide the quantitative examination of bioactive mixes. Customarily, cutting edge meds rely<br />on the phytochemicals got from the plant source in bigger extents. Numerous bioactive auxiliary metabolites have a positive metabolic reaction on<br />different human diseases.<br />Methods: In the present examination, Artemisia nilagirica, leaves were gathered, dried, powdered and put away in hermetically sealed compartments<br />for quantitative investigation of phytochemicals according to standard strategies.<br />Results: The methanolic leaf concentrate of enrolled 4.33 mg of alkaloids, 1.22 mg of saponins, 12.4 mg of tannins, 24.3 mg of glycosides, 10.2 mg<br />terpenoids, 1.33 mg of coumarin, 59.4 mg of amino acids, 12.2 mg of fatty acids, 17.2 mg of flavonoids, 10.2 mg of phenols, and steroids in follows<br />separately.<br />Conclusion: The plant has a high helpful quality as far as an assortment of phytochemicals from leaf remove and had let to a sure level toward<br />extraction and refinement of specific bioactive mixes for human nourishment.<br />Keywords: Artemisia nilagirica, Secondary metabolites, Quantitative analysis, Leaf extract, Flavonoids.</p>

scholarly journals AGERATUM CONYZOIDES L. (PEMANFAATAN SEBAGAI OBAT DAN BIOAKTIVITASNYA)

2019 ◽  
Vol 11 (3) ◽  
pp. 197
Author(s):  
Marina Silalahi
Keyword(s):  
Fatty Acids ◽  
Secondary Metabolites ◽  
Traditional Medicine ◽  
Wild Plants ◽  
Ageratum Conyzoides ◽  
Comprehensive Information

ABSTRACTAgeratum conyzoides or badotan is a wild plants which uses as traditional medicine. This plant has a distinctive aroma similar to "the smell of goats" so it is called "goatweed". This article aims to explain the use of A. conyzoides as a drug and its bioactivity. The writing of this article is based on the study of literature obtained online and offline including various scientific articles then reviewed and synthesized so as to provide comprehensive information regarding the use of A. conyzoides as traditional medicine. In traditional medicine, Ageratum conyzoides is used as medicine for wounds, ulcers, and fever. Ageratum conyzoides have secondary metabolites such as terpenoids, flavonoids, steroids, terpenes, saponins, fatty acids, and alkaloids, with the main compounds stigmasterol and β-sitosterol. Bioactivity of A. conyzoides are antihistamine, antimicrobial, antiplasmodial, cytoprotective, analgesic, antioxidant and anti diabetes mellitus.Keywords: Ageratum conyzoides, antimicrobial, β-sitosterol, cytoprotective, analgesic. ABSTRAKAgeratum conyzoides atau badotan merupakan salah satu tumbuhan liar yang banyak dimanfaatkan sebagai obat tradisional. Tumbuhan ini memiliki aroma khas mirip dengan “bau kambing” sehingga disebut juga sebagai “goatweed”. Artikel ini bertujuan untuk menjelaskan pemanfaatan A. conyzoides sebagai obat dan bioaktivitasnya. Penulisan artikel ini didasarkan pada kajian literatur yang diperoleh secara online maupun offline meliputi berbagai artikel ilmiah kemudian dikaji dan disintesakan sehingga memberikan informasi yang kompehensif mengenai pemanfaatan A. conyzoides sebagai obat tradisional. Dalam pengobatan tradisional Ageratum conyzoides dimanfaatkan sebagai obat luka, bisul, dan demam. Ageratum conyzoides mengandung metabolit sekunder dari golongan terpenoid, flavonoid, steroid, terpen, senyawa, saponin, asam lemak, dan alkaloid, dengan senyawa utama stigmasterol dan β‐sitosterol. Bioaktivitas yang dimiliki oleh A. conyzoides antara lain sebagai anti histamin, antimikroba, antiplasmodial, sitoprotektif, analgesik, antioksidan dan anti diabetes mellitus.Kata Kunci : Ageratum conyzoides, antimikroba, β‐sitosterol, sitoprotektif, analgesik.

Secondary metabolites of the genus Crotalaria (Rattlepods) and their medicinal importance – A review

2020 ◽  
pp. 1-7
Author(s):  
Muhammad Sarwar Yaqub ◽  
Bushra Basher ◽  
Rozina Aslam
Keyword(s):  
Rheumatoid Arthritis ◽  
Fatty Acids ◽  
Wound Healing ◽  
Drug Discovery ◽  
Secondary Metabolites ◽  
Metabolic Pathways ◽  
Growth And Development ◽  
Chemical Compounds ◽  
Diverse Group ◽  
The World

This review describes the genus Crotalaria focusing on its secondary metabolites and their medicinal applications. The genus Crotalaria of Fabaceae or Leguminosae family have about 600 species which are distributed in tropic and sub-tropic regions of the world. They are medicinally important due to production of various compounds. Traditional early medicines and drug discovery were based on natural products. Organisms produce some chemical compounds by their metabolic pathways that are not necessary for their growth and development and are known as secondary metabolites. This diverse group of compounds is synthesized by algae, plants, animals and fungi. These metabolites consist of variety of compounds such as phenols, coumarins, terpenoids, flavonoids, alkaloids, steroids and fatty acids. Secondary metabolites obtained from crotalaria exhibit anticancer, anti-rheumatoid arthritis, anti-allergic, antioxidant, antimicrobial, antiaging and wound healing activities along with many other medicinal applications.

scholarly journals Distribution and evolution of secondary metabolites in Eriocaulaceae, Lythraceae and Velloziaceae from "campos rupestres"

2000 ◽  
Vol 23 (4) ◽  
pp. 931-940 ◽  
Author(s):  
Antonio Salatino ◽  
Maria Luiza Faria Salatino ◽  
Déborah Yara A.C. dos Santos ◽  
Márcia Cristina B. Patrício
Keyword(s):  
Fatty Acids ◽  
Secondary Metabolites ◽  
Salient Feature ◽  
Morphological Characters ◽  
Epicuticular Wax ◽  
Campos Rupestres ◽  
Carbon Chains ◽  
Cladistic Analyses ◽  
Flavonoid Patterns ◽  
Molecular Characters

Hypotheses are presented on the evolution of structural patterns of secondary metabolites (flavonoids and foliar wax alkanes) and fatty acids of families of "campos rupestres". The distribution of fatty acids is given for genera of Lythraceae, with emphasis on Cuphea (supposedly more advanced) and Diplusodon. Compounds with saturated short chains represent a derived condition in Lythraceae although they are probably restricted to Cuphea. It is suggested that evolution selected for more complex flavonoid patterns in Cuphea, with the inclusion of C-glycoflavones and methoxylated flavonols (rhamnetin and isorhamnetin), which are not found in members of Diplusodon and Lafoensia. The supposedly primitive groups of Eriocaulaceae (e.g., Paepalanthus) presented more complex flavonoid patterns characterized by flavones and flavonols, the latter frequently being 6-hydroxylated or methoxylated. More advanced groups of Eriocaulaceae (e.g., Leiothrix and Syngonanthus) apparently possess only flavones, C-glycoflavones are a salient feature of species with smaller habits. In Velloziaceae, members of the primitive subfamily Vellozioideae show distribution of alkanes of foliar epicuticular wax in which C27, C29 or C31 predominate; members of the derived subfamily Barbacenioideae usually show distributions with a predominance of C33 or C35, while species of Pleurostima (Barbacenioideae) have C31 as the main homologue, thus being intermediate between the two subfamilies. It is suggested that the evolution of alkanes in Velloziaceae follows a trend toward elongation of carbon chains. The condition of advanced or primitive chemical patterns is inferred from the results of cladistic analyses based on morphological characters (Eriocaulaceae and Lythraceae), and morphological and molecular characters (Velloziaceae).

Theoretical Study on Adiabatic Electron Affinity of Fatty Acids

2021 ◽  
Author(s):  
Yaxin Yang ◽  
Wenrui Zheng ◽  
Hongyun Xie ◽  
Lufei Ren ◽  
Xiaofei Xu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Secondary Metabolites ◽  
Electron Affinity ◽  
Theoretical Study ◽  
Vital Role ◽  
Energy Sources ◽  
Signal Molecules ◽  
Human Metabolism ◽  
Adiabatic Electron Affinity

As nutrients, secondary metabolites, essential signal molecules and energy sources, fatty acids play a vital role in biomedicine, pharmacokinetics and human metabolism. The reduction of fatty acids is one of...

scholarly journals A SYSTEMATIC REVIEW OF TRADITIONAL USES BIOACTIVE PHYTOCONSTITUENTS OF GENUS EHRETIA

2018 ◽  
Vol 11 (6) ◽  
pp. 88
Author(s):  
Abha Shukla ◽  
Amanpreet Kaur
Keyword(s):  
Systematic Review ◽  
Fatty Acids ◽  
North America ◽  
Secondary Metabolites ◽  
Biological Activities ◽  
Tropical Asia ◽  
Medicinal Use ◽  
Pharmacological Studies ◽  
Long Time ◽  
India And China

 The plants of the genus Ehretia composed of about 150 species mainly distributed in tropical Asia, Africa, Australia, and North America. They have been used as traditional and folk medicines to treat various ailments in Japan, India, and China for a long time. Previous phytochemical screenings demonstrated that the Ehretia plants mainly contain fatty acids, phenolic acids, flavonoids, cyanogenetic glycosides, and benzoquinones and other constituents from different chemical classes. The pharmacological studies confirmed that the crude extracts or individual compounds from the genus showed antioxidant, anti-inflammatory, antibacterial, antiarthritic, antitubercular, and antiallergic activities, as well as anti-snake venom property. In this review, we presented a summary of the secondary metabolites isolated from different species of Ehretia based on the published literatures up to March 2017. In addition to the traditional medicinal use of Ehretia plants, we focused on the known biological activities of the plants and discussed them in detail here.

scholarly journals Description of aSulfitobacterStrain and Its Extracellular Cyclodipeptides

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Cong Long ◽  
Xiao-Ling Lu ◽  
Yun Gao ◽  
Bing-Hua Jiao ◽  
Xiao-Yu Liu
Keyword(s):  
Fatty Acids ◽  
Secondary Metabolites ◽  
Sequence Comparison ◽  
Marine Bacterium ◽  
Gene Sequence ◽  
Growth Conditions ◽  
The East China Sea ◽  
Deep Seawater ◽  
16S Rdna Gene ◽  
Series Of Experiments

A marine bacterium M44 was separated from 30 m deep seawater in the East China Sea (26° 28.3′ N 122° 29.0′ E) in 2006. 16S rDNA gene sequence comparison showed that the strain M44 was a member of the genusSulfitobacterand highly similar to KMM 3554T. A series of experiments demonstrated that this strain M44 had many distinctive characteristics: its cells were gram-negative and mesophilic; its colonies were slightly yellowish, round, convex, and smooth; and it could grow at 10–28°C, pH 6.0–10.0, and in the presence of 0–12.5% (w/v) NaCl; the optimum growth conditions were 25°C and pH 7.0, and the optimum Na+concentration was 2.5%. In addition, strain M44 contained 18 : 1 ω7c, 11 methyl 18 : 1 ω7c and 16 : 0 fatty acids as major fatty acids, and the genomic DNA G+C content was 58.04 mol%. According to our results of the secondary metabolites, six cyclodipeptides were isolated from the strain M44, which were Cyclo (Val-Leu), Cyclo (Phe-Val), Cyclo (Phe-Leu), Cyclo (Leu-Ile), Cyclo (Phe-Ile), and Cyclo (Trp-Pro). It is the first study of secondary metabolites isolated from this genus.

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