Novel Polycyclic Guanidine Alkaloids from Two Marine Sponges of the GenusMonanchora

2000 ◽  
Vol 63 (2) ◽  
pp. 193-196 ◽  
Author(s):  
J. C. Braekman ◽  
D. Daloze ◽  
R. Tavares ◽  
E. Hajdu ◽  
R. W. M. Van Soest
Keyword(s):  
Marine Sponges ◽  
Guanidine Alkaloids

Insights into the Biosynthesis of Cyclic Guanidine Alkaloids from Crambeidae Marine Sponges

2018 ◽  
Vol 58 (2) ◽  
pp. 520-525 ◽  
Author(s):  
Siguara B. L. Silva ◽  
François Oberhänsli ◽  
Marie-Aude Tribalat ◽  
Grégory Genta-Jouve ◽  
Jean-Louis Teyssié ◽  
...  
Keyword(s):  
Marine Sponges ◽  
Guanidine Alkaloids

scholarly journals Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges

Marine Drugs ◽  
2016 ◽  
Vol 14 (4) ◽  
pp. 77 ◽  
Author(s):  
Estelle Sfecci ◽  
Thierry Lacour ◽  
Philippe Amade ◽  
Mohamed Mehiri
Keyword(s):  
Marine Sponges ◽  
Guanidine Alkaloids

Insights into the Biosynthesis of Cyclic Guanidine Alkaloids from Crambeidae Marine Sponges

2018 ◽  
Vol 131 (2) ◽  
pp. 530-535
Author(s):  
Siguara B. L. Silva ◽  
François Oberhänsli ◽  
Marie-Aude Tribalat ◽  
Grégory Genta-Jouve ◽  
Jean-Louis Teyssié ◽  
...  
Keyword(s):  
Marine Sponges ◽  
Guanidine Alkaloids

scholarly journals Identification of Fromiamycalin and Halaminol A from Australian Marine Sponge Extracts with Anthelmintic Activity against Haemonchus contortus

Marine Drugs ◽  
2019 ◽  
Vol 17 (11) ◽  
pp. 598 ◽  
Author(s):  
H. Herath ◽  
Sarah Preston ◽  
Abdul Jabbar ◽  
Jose Garcia-Bustos ◽  
Aya Taki ◽  
...  
Keyword(s):  
Haemonchus Contortus ◽  
Marine Invertebrates ◽  
Anthelmintic Activity ◽  
Marine Sponges ◽  
Parasitic Nematodes ◽  
Natural Ecosystems ◽  
Bioassay Guided Fractionation ◽  
Guanidine Alkaloids ◽  
Nematocidal Activity

There is an urgent need to discover and develop new anthelmintics for the treatment of parasitic nematodes of veterinary importance to circumvent challenges linked to drug resistant parasites. Being one of the most diverse natural ecosystems, the marine environment represents a rich resource of novel chemical entities. This study investigated 2000 extracts from marine invertebrates, collected from Australian waters, for anthelmintic activity. Using a well-established in vitro bioassay, these extracts were screened for nematocidal activity against Haemonchus contortus — a socioeconomically important parasitic nematode of livestock animals. Extracts (designated Mu-1, Ha-1 and Ha-2) from two marine sponges (Monanchora unguiculata and Haliclona sp.) each significantly affected larvae of H. contortus. Individual extracts displayed a dose-dependent inhibition of both the motility of exsheathed third-stage larvae (xL3s) and the development of xL3s to fourth-stage larvae (L4s). Active fractions in each of the three extracts were identified using bioassay-guided fractionation. From the active fractions from Monanchora unguiculata, a known pentacyclic guanidine alkaloid, fromiamycalin (1), was purified. This alkaloid was shown to be a moderately potent inhibitor of L4 development (half-maximum inhibitory concentration (IC50) = 26.6 ± 0.74 µM) and L4 motility (IC50 = 39.4 ± 4.83 µM), although it had a relatively low potency at inhibiting of xL3 motility (IC50 ≥ 100 µM). Investigation of the active fractions from the two Haliclona collections led to identification of a mixture of amino alcohol lipids, and, subsequently, a known natural product halaminol A (5). Anthelmintic profiling showed that 5 had limited potency at inhibiting larval development and motility. These data indicate that fromiamycalin, other related pentacyclic guanidine alkaloids and/or halaminols could have potential as anthelmintics following future medicinal chemistry efforts.

Bioactive Guanidine Alkaloids from Two Caribbean Marine Sponges

2009 ◽  
Vol 72 (9) ◽  
pp. 1589-1594 ◽  
Author(s):  
Rémi Laville ◽  
Olivier P. Thomas ◽  
Fabrice Berrué ◽  
Diana Marquez ◽  
Jean Vacelet ◽  
...  
Keyword(s):  
Marine Sponges ◽  
Guanidine Alkaloids

Ilimaquinone and minor metabolites from Polynesian marine sponges: Isolation and ecology

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
A Boufridi ◽  
C Debitus ◽  
A Maciuk ◽  
L Evanno ◽  
E Poupon
Keyword(s):  
Marine Sponges

Agelamadins, bromopyrrole alkaloids from Okinawan marine sponges Agelas spp.

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
N Tanaka ◽  
T Kusama ◽  
Y Kashiwada ◽  
J Kobayashi
Keyword(s):  
Marine Sponges

Production of Novel Bioactive Compounds by the Bacteria Associated with Some Marine Sponges of Gulf of Mannar and Palk Bay, Southeast Coast of India

2018 ◽  
Vol 6 (8) ◽  
pp. 183
Author(s):  
V. Ramadas ◽  
G. Chandralega
Keyword(s):  
Bioactive Compounds ◽  
Bacterial Species ◽  
Marine Sponges ◽  
Marine Organisms ◽  
Gulf Of Mannar ◽  
Bacterial Symbionts ◽  
Palk Bay ◽  
Excellent Source

Sponges, exclusively are aquatic and mostly marine, are found from the deepest oceans to the edge of the sea. There are approximately 15,000 species of sponges in the world, of which, 150 occur in freshwater, but only about 17 are of commercial value. A total of 486 species of sponges have been identified in India. In the Gulf of Mannar and Palk Bay a maximum of 319 species of sponges have been recorded. It has been proved that marine organisms are excellent source of bioactive secondary metabolites and number of compounds of originated from marine organisms had been reported to possess in-vitro and in-vivo immuno stimulatory activity. Extracts from 20 sponge species were tested for bacterial symbionts and bioactive compounds were isolated from such associated bacterial species in the present study.

Neuroprotective Activities of Marine Natural Products from Marine Sponges

2016 ◽  
Vol 23 (4) ◽  
pp. 360-382 ◽  
Author(s):  
Mousa Alghazwi ◽  
Yen Qi Kan ◽  
Wei Zhang ◽  
Wei Ping Gai ◽  
Xiao-Xin Yan
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Marine Sponges
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