Triterpenoids from the Leaves ofDiospyros kaki(Persimmon) and Their Inhibitory Effects on Protein Tyrosine Phosphatase 1B

2008 ◽  
Vol 71 (10) ◽  
pp. 1775-1778 ◽  
Author(s):  
Phuong Thien Thuong ◽  
Chul Ho Lee ◽  
Trong Tuan Dao ◽  
Phi Hung Nguyen ◽  
Wan Gi Kim ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Inhibitory Effects ◽  
Protein Tyrosine

Pterocarpans with inhibitory effects on protein tyrosine phosphatase 1B from Erythrina lysistemon Hutch.

2009 ◽  
Vol 70 (17-18) ◽  
pp. 2053-2057 ◽  
Author(s):  
Trong Tuan Dao ◽  
Phi Hung Nguyen ◽  
Phuong Thien Thuong ◽  
Keon Wook Kang ◽  
MinKyun Na ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Inhibitory Effects ◽  
Protein Tyrosine

New 5-deoxyflavonoids and their inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) activity

2011 ◽  
Vol 19 (11) ◽  
pp. 3378-3383 ◽  
Author(s):  
Phi Hung Nguyen ◽  
Trong Tuan Dao ◽  
Jayeon Kim ◽  
Do Tuan Phong ◽  
Derek Tantoh Ndinteh ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Inhibitory Effects ◽  
Protein Tyrosine

Oleanane hemiacetal glycosides from Gymnema latifolium and their inhibitory effects on protein tyrosine phosphatase 1B

2020 ◽  
Vol 170 ◽  
pp. 112181 ◽  
Author(s):  
Ha Thanh Tung Pham ◽  
Byeol Ryu ◽  
Hyo Moon Cho ◽  
Ba-Wool Lee ◽  
Woo Young Yang ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Inhibitory Effects ◽  
Protein Tyrosine

Inhibition of Protein Tyrosine Phosphatase 1B by Lutein Derivatives isolated from Mexican Oregano (Lippia graveolens)

2018 ◽  
Vol 17 (3) ◽  
pp. 134-139
Author(s):  
R.M. Perez-Gutierrez
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Inhibitory Activity ◽  
Spectroscopic Data ◽  
Methanol Extract ◽  
Tyrosine Phosphatase ◽  
Positive Control ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Ic50 Value ◽  
Ic50 Values

Methanol extract from Lippia graveolens (Mexican oregano) was studied in order to identify inhibitory bioactives for protein tyrosine phosphatase 1B (PTP1B). Known flavone as lutein (1), and another flavone glycoside such as lutein-7-o-glucoside (2), 6-hydroxy-lutein-7-ohexoside (3) and lutein-7-o-ramnoide (4) were isolated from methanol extract of aerial parts of the Lippia graveolens. All isolates were identified based on extensive spectroscopic data analysis, including UV, IR, NMR, MS and compared with spectroscopic data previously reported. These flavones were evaluated for PTP1B inhibitory activity. Among them, compounds 1 and 3 displayed potential inhibitory activity against PTP1B with IC50 values of 7.01 ± 1.25 μg/ml and 18.4 μg/ml, respectively. In addition, compound 2 and 4 showed moderate inhibitory activity with an IC50 value of 23.8 ± 6.21 and 67.8 ± 5.80 μg/ml respectively. Among the four compounds, luteolin was found to be the most potent PTP1B inhibitor compared to the positive control ursolic acid, with an IC50 value of 8.12 ± 1.06 μg/ml. These results indicate that flavonoids constituents contained in Lippia graveolens can be considered as a natural source for the treatment of type 2 diabetes.

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