Sulforaphane Induces Cell-Cycle Arrest and Apoptosis in Cultured Human Lung Adenocarcinoma LTEP-A2 Cells and Retards Growth of LTEP-A2 Xenografts in Vivo

2008 ◽  
Vol 71 (11) ◽  
pp. 1911-1914 ◽  
Author(s):  
Hao Liang ◽  
Baitang Lai ◽  
Qipeng Yuan
Keyword(s):  
Cell Cycle ◽  
Lung Adenocarcinoma ◽  
Cell Cycle Arrest ◽  
Human Lung ◽  
Human Lung Adenocarcinoma ◽  
Cycle Arrest

Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells

2004 ◽  
Vol 68 (7) ◽  
pp. 1453-1464 ◽  
Author(s):  
Gee-Chen Chang ◽  
Shih-Lan Hsu ◽  
Jia-Rong Tsai ◽  
Fong-Pin Liang ◽  
Sheng-Yi Lin ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Lung Adenocarcinoma ◽  
Cell Cycle Arrest ◽  
Molecular Mechanisms ◽  
Human Lung ◽  
A549 Cells ◽  
Human Lung Adenocarcinoma ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
Lung Adenocarcinoma A549

scholarly journals Molecular Mechanisms Underlying Yatein-Induced Cell-Cycle Arrest and Microtubule Destabilization in Human Lung Adenocarcinoma Cells

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1384 ◽  
Author(s):  
Shang-Tse Ho ◽  
Chi-Chen Lin ◽  
Yu-Tang Tung ◽  
Jyh-Horng Wu
Keyword(s):  
Cell Cycle ◽  
Antitumor Activity ◽  
Lung Adenocarcinoma ◽  
Cell Cycle Progression ◽  
Molecular Mechanisms ◽  
Human Lung ◽  
Microtubule Dynamics ◽  
Cycle Progression ◽  
Human Lung Adenocarcinoma

Yatein is an antitumor agent isolated from Calocedrus formosana Florin leaves extract. In our previous study, we found that yatein inhibited the growth of human lung adenocarcinoma A549 and CL1-5 cells by inducing intrinsic and extrinsic apoptotic pathways. To further uncover the effects and mechanisms of yatein-induced inhibition on A549 and CL1-5 cell growth, we evaluated yatein-mediated antitumor activity in vivo and the regulatory effects of yatein on cell-cycle progression and microtubule dynamics. Flow cytometry and western blotting revealed that yatein induces G2/M arrest in A549 and CL1-5 cells. Yatein also destabilized microtubules and interfered with microtubule dynamics in the two cell lines. Furthermore, we evaluated the antitumor activity of yatein in vivo using a xenograft mouse model and found that yatein treatment altered cyclin B/Cdc2 complex expression and significantly inhibited tumor growth. Taken together, our results suggested that yatein effectively inhibited the growth of A549 and CL1-5 cells possibly by disrupting cell-cycle progression and microtubule dynamics.

Novel tetrahydroacridine derivatives inhibit human lung adenocarcinoma cell growth by inducing G1 phase cell cycle arrest and apoptosis

2014 ◽  
Vol 68 (8) ◽  
pp. 959-967 ◽  
Author(s):  
Paulina Olszewska ◽  
Elżbieta Mikiciuk-Olasik ◽  
Katarzyna Błaszczak-Świątkiewicz ◽  
Jacek Szymański ◽  
Paweł Szymański
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Lung Adenocarcinoma ◽  
Cell Cycle Arrest ◽  
Human Lung ◽  
Phase Cell ◽  
G1 Phase ◽  
Adenocarcinoma Cell ◽  
Cycle Arrest ◽  
Human Lung Adenocarcinoma Cell

scholarly journals Overexpression of cyclin L2 induces apoptosis and cell-cycle arrest in human lung cancer cells

2007 ◽  
Vol 120 (10) ◽  
pp. 905-909 ◽  
Author(s):  
Hong-li LI ◽  
Tong-shan WANG ◽  
Xiao-yu LI ◽  
Nan LI ◽  
Ding-zhi HUANG ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Cycle Arrest ◽  
Human Lung Cancer Cells
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