Antifungal Activity of Meridine, a Natural Product from the Marine Sponge Corticium sp.

1992 ◽  
Vol 55 (11) ◽  
pp. 1664-1668 ◽  
Author(s):  
Peter J. McCarthy ◽  
Tara P. Pitts ◽  
Geewananda P. Gunawardana ◽  
Michelle Kelly-Borges ◽  
Shirley A. Pomponi
Keyword(s):  
Antifungal Activity ◽  
Natural Product ◽  
Marine Sponge

scholarly journals Oceanalin B, a Hybrid α,ω-Bifunctionalized Sphingoid Tetrahydroisoquinoline β-Glycoside from the Marine Sponge Oceanapia sp.

Marine Drugs ◽  
2021 ◽  
Vol 19 (11) ◽  
pp. 635
Author(s):  
Tatyana N. Makarieva ◽  
Natalia V. Ivanchina ◽  
Pavel S. Dmitrenok ◽  
Alla G. Guzii ◽  
Valentin A. Stonik ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Antifungal Activity ◽  
Natural Product ◽  
Marine Sponge ◽  
Biological Activities ◽  
Chemical Degradation ◽  
Etoh Extract ◽  
Absolute Stereochemistry ◽  
In Vitro Antifungal Activity

Oceanalin B (1), an α,ω-bipolar natural product belonging to a rare family of sphingoid tetrahydoisoquinoline β-glycosides, was isolated from the EtOH extract of the lyophilized marine sponge Oceanapia sp. as the second member of the series after oceanalin A (2) from the same animal. The compounds are of particular interest due to their biogenetically unexpected structures as well as their biological activities. The structure and absolute stereochemistry of 1 as a α,ω-bifunctionalized sphingoid tetrahydroisoquinoline β-glycoside was elucidated using NMR, CD and MS spectral analysis and chemical degradation. Oceanalin B exhibited in vitro antifungal activity against Candidaglabrata with a MIC of 25 μg/mL.

scholarly journals Antifungal Activity of (+)-Curcuphenol, a Metabolite from the Marine Sponge Didiscus oxeata

Marine Drugs ◽  
2004 ◽  
Vol 2 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Helena Gaspar ◽  
Sonia Feio ◽  
Ana Rodrigues ◽  
Rob Van Soest
Keyword(s):  
Antifungal Activity ◽  
Marine Sponge

Natural alkaloid tryptanthrin exhibits novel anticryptococcal activity

2020 ◽  
Author(s):  
Chi-Jan Lin ◽  
Ya-Lin Chang ◽  
Yu-Liang Yang ◽  
Ying-Lien Chen
Keyword(s):  
Cell Cycle ◽  
Antifungal Activity ◽  
Signaling Pathways ◽  
Natural Product ◽  
Cyclosporine A ◽  
Cryptococcal Meningitis ◽  
Synergistic Effects ◽  
Calcineurin Inhibitors ◽  
Genes Encoding ◽  
Cryptococcus Species

Abstract Cryptococcal meningitis is a prevalent invasive fungal infection that causes around 180 000 deaths annually. Currently, treatment for cryptococcal meningitis is limited and new therapeutic options are needed. Historically, medicinal plants are used to treat infectious and inflammatory skin infections. Tryptanthrin is a natural product commonly found in these plants. In this study, we demonstrated that tryptanthrin had antifungal activity with minimum inhibitory concentration (MIC) of 2 μg/ml against Cryptococcus species and of 8 μg/ml against Trichophyton rubrum. Further analysis demonstrated that tryptanthrin exerted fungistatic and potent antifungal activity at elevated temperature. In addition, tryptanthrin exhibited a synergistic effect with the calcineurin inhibitors FK506 and cyclosporine A against Cryptococcus neoformans. Furthermore, our data showed that tryptanthrin induced cell cycle arrest at the G1/S phase by regulating the expression of genes encoding cyclins and the SBF/MBF complex (CLN1, MBS1, PCL1, and WHI5) in C. neoformans. Screening of a C. neoformans mutant library further revealed that tryptanthrin was associated with various transporters and signaling pathways such as the calcium transporter (Pmc1) and protein kinase A signaling pathway. In conclusion, tryptanthrin exerted novel antifungal activity against Cryptococcus species through a mechanism that interferes with the cell cycle and signaling pathways. Lay Summary The natural product tryptanthrin had antifungal activity against Cryptococcus species by interfering cell cycle and exerted synergistic effects with immunosuppressants FK506 and cyclosporine A. Our findings suggest that tryptanthrin may be a potential drug or adjuvant for the treatment of cryptococcosis.

scholarly journals Biological and Chemical Diversity of Marine Sponge-Derived Microorganisms over the Last Two Decades from 1998 to 2017

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 853 ◽  
Author(s):  
Mei-Mei Cheng ◽  
Xu-Li Tang ◽  
Yan-Ting Sun ◽  
Dong-Yang Song ◽  
Yu-Jing Cheng ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Natural Product ◽  
Marine Sponge ◽  
Marine Sponges ◽  
Chemical Diversity ◽  
Comprehensive Overview ◽  
Bioactive Secondary Metabolites ◽  
The Relationship ◽  
Product Chemistry

Marine sponges are well known as rich sources of biologically natural products. Growing evidence indicates that sponges harbor a wealth of microorganisms in their bodies, which are likely to be the true producers of bioactive secondary metabolites. In order to promote the study of natural product chemistry and explore the relationship between microorganisms and their sponge hosts, in this review, we give a comprehensive overview of the structures, sources, and activities of the 774 new marine natural products from sponge-derived microorganisms described over the last two decades from 1998 to 2017.

scholarly journals Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin

2009 ◽  
Vol 8 (10) ◽  
pp. 2852-2860 ◽  
Author(s):  
Galina Kuznetsov ◽  
Karen TenDyke ◽  
Murray J. Towle ◽  
Hongsheng Cheng ◽  
Junke Liu ◽  
...  
Keyword(s):  
Natural Product ◽  
Marine Sponge

Structurally diverse hamigerans from the New Zealand marine sponge Hamigera tarangaensis: NMR-directed isolation, structure elucidation and antifungal activity

2013 ◽  
Vol 11 (46) ◽  
pp. 8041 ◽  
Author(s):  
A. Jonathan Singh ◽  
Jonathan D. Dattelbaum ◽  
Jessica J. Field ◽  
Zlatka Smart ◽  
Ethan F. Woolly ◽  
...  
Keyword(s):  
New Zealand ◽  
Antifungal Activity ◽  
Marine Sponge ◽  
Structure Elucidation

P3-352: Leucettines, a family of pharmacological inhibitors of DYRKs and CLKs derived from the marine sponge: Natural product Leucettamine B

2012 ◽  
Vol 8 (4S_Part_16) ◽  
pp. P580-P580
Author(s):  
Tania Tahtouh ◽  
Emilie Durieu ◽  
François Carreaux ◽  
Jean-Pierre Bazureau ◽  
Johann Meunier ◽  
...  
Keyword(s):  
Natural Product ◽  
Marine Sponge

scholarly journals Yeast-based screening of natural product extracts results in the identification of prion inhibitors from a marine sponge

Prion ◽  
2018 ◽  
Vol 12 (3-4) ◽  
pp. 234-244 ◽  
Author(s):  
Laurence K. Jennings ◽  
Ishtiaq Ahmed ◽  
Alan L. Munn ◽  
Anthony R. Carroll
Keyword(s):  
Natural Product ◽  
Marine Sponge

scholarly journals Antifungal activity of a novel 3-Alkylpyridine analog derived from Marine sponge alkaloids

2021 ◽  
Vol 93 (suppl 4) ◽  
Author(s):  
JÉSSICA T. ANDRADE ◽  
WILLIAM G. LIMA ◽  
CAMILA S. BARBOSA ◽  
ALESSANDRA M.M.N. GONÇALVES ◽  
MAYRA K.P. SILVA ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Marine Sponge
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