A New Bioactive Derivative of Avarol from the Marine Sponge Dysidea avara

1989 ◽  
Vol 52 (3) ◽  
pp. 646-648 ◽  
Author(s):  
A. Crispino ◽  
A. de Giulio ◽  
S. de Rosa ◽  
G. Strazzullo
Keyword(s):  
Marine Sponge ◽  
Dysidea Avara

scholarly journals Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone

2007 ◽  
Vol 72 (12) ◽  
pp. 1271-1274 ◽  
Author(s):  
Ivana Pajic ◽  
Zoran Vujcic ◽  
Miroslava Vujcic ◽  
Irena Novakovic ◽  
Dusan Sladic ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Isoelectric Focusing ◽  
Marine Sponge ◽  
Protein A ◽  
Hemagglutination Activity ◽  
Sds Page ◽  
Dysidea Avara

The quinone avarone, isolated from the marine sponge Dysidea avara, possesses the ability to chemically modify proteins. In this work, modification of lectin isolated from the coral Gerardia savaglia by avarone was examined. The techniques used for studying the modification were: SDS PAGE, isoelectric focusing and hemagglutination testing. The results of the SDS PAGE indicate dimerization of the protein. A shift of the pI toward lower value occurs upon modification. The change of the hemagglutination activity of the protein confirms that chemical modification of G. savaglia lectin by avarone changes its ability to interact with the membrane of erythrocytes.

Dysidavarones A–D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara

2011 ◽  
Vol 14 (1) ◽  
pp. 202-205 ◽  
Author(s):  
Wei-Hua Jiao ◽  
Xiao-Jun Huang ◽  
Ji-Si Yang ◽  
Fan Yang ◽  
Shu-Jian Piao ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Dysidea Avara

Avarol, a cytostatically active compound from the marine sponge dysidea avara

1985 ◽  
Vol 80 (1) ◽  
pp. 47-52 ◽  
Author(s):  
W.E.G. Müller ◽  
R.K. Zahn ◽  
M.J. Gasić ◽  
N. Dogović ◽  
A. Maidhof ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Active Compound ◽  
Dysidea Avara

scholarly journals Chemical profiling and anti-psoriatic activity of marine sponge (Dysidea avara) in induced imiquimod-psoriasis-skin model

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241582
Author(s):  
Mostafa Khaledi ◽  
Behzad Sharif Makhmal Zadeh ◽  
Annahita Rezaie ◽  
Melika Nazemi ◽  
Mehdi Safdarian ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Skin Permeation ◽  
Clinical Results ◽  
In Vivo Studies ◽  
Area Index ◽  
Methanolic Extracts ◽  
Tnf Α ◽  
Dysidea Avara ◽  
Anti Inflammatory

Since Marine sponge Dysidea avara is regarded as a source of anti-inflammatory compounds, we decided to evaluate its potential anti-psoriatic activity in a psoriasis Imiquimod-induced in the mouse model. Psoriatic mice were treated with three different methanolic extracts of Dysidea avara compared with betamethasone-treated mice in in- vivo studies. Clinical skin severity was assessed with the psoriasis area index (PASI), whilst ELISA detected the expression of TNF-α, IL-17A, and IL-22. Dysidea avara activity was studied by employing GC-MS (to distinguish compounds), HPTLC (for skin permeation and accumulation), and SEA DOCK to predict single compound potential anti-inflammatory activity. After 7 days of treatment, mice treated with Dysidea avara displayed a dose-dependent, statistically significant improvement compared to controls (p< 0.001). In line with the clinical results, ELISA revealed a statistically significant decrease in IL-22, IL-17A, and TNF-α after treatment; the same SEA DOCK analysis suggests a possible anti-psoriatic activity of the extracts.

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