Spongialactone A, a New Spongian Diterpene from Spongia arabica

1988 ◽  
Vol 51 (6) ◽  
pp. 1243-1245 ◽  
Author(s):  
S. Hirsch ◽  
Y. Kashman
Keyword(s):  
Spongian Diterpene

scholarly journals Three New Spongian Diterpenes from the Fijian Marine Sponge Spongia sp

2009 ◽  
Vol 4 (3) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Harald Gross ◽  
Anthony D. Wright ◽  
Uwe Reinscheid ◽  
Gabriele M. König
Keyword(s):  
Molecular Modeling ◽  
Marine Sponge ◽  
Spectroscopic Data ◽  
Chemical Investigation ◽  
Complete Analysis ◽  
Quantum Mechanical ◽  
Quantum Mechanical Calculations ◽  
Fiji Islands ◽  
Combined Strategy ◽  
Spongian Diterpene

Chemical investigation of the marine sponge Spongia sp., collected from the Fiji Islands resulted in the isolation of three new furanoditerpenoids 1-3, along with the known compounds epispongiatriol (4) and 17,19-dihydroxyspongia-13(16),14-dien-2,3-dione (5) While 1 is a new spongian diterpene with a modified oxidation pattern, compounds 2 and 3 represent two new ring A-contracted spongians, displaying a novel and unprecedented nor-spongian carbon skeleton. Despite their labile nature the structures could be established through a combined strategy including complete analysis of spectroscopic data (NMR, MS), molecular modeling and quantum-mechanical calculations.

Two new spongian diterpene analogues isolated from the marine sponge Acanthodendrilla sp

2018 ◽  
Vol 34 (8) ◽  
pp. 1053-1060 ◽  
Author(s):  
Margarida Costa ◽  
Rogelio Fernández ◽  
Marta Pérez ◽  
Margrét Thorsteinsdottir
Keyword(s):  
Marine Sponge ◽  
Spongian Diterpene

Ceylonins A–F, Spongian Diterpene Derivatives That Inhibit RANKL-Induced Formation of Multinuclear Osteoclasts, from the Marine Sponge Spongia ceylonensis

2016 ◽  
Vol 80 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Ahmed H. El-Desoky ◽  
Hikaru Kato ◽  
Ippei Kagiyama ◽  
Yuki Hitora ◽  
Fitje Losung ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Spongian Diterpene

scholarly journals Cytotoxic Furanoditerpenes from the Sponge Spongia tubulifera Collected in the Mexican Caribbean

Marine Drugs ◽  
2019 ◽  
Vol 17 (7) ◽  
pp. 416 ◽  
Author(s):  
Dawrin Pech-Puch ◽  
Jaime Rodríguez ◽  
Bastien Cautain ◽  
Carlos Alfredo Sandoval-Castro ◽  
Carlos Jiménez
Keyword(s):  
Density Functional ◽  
2D Nmr ◽  
Functional Theory ◽  
Planar Structures ◽  
Mexican Caribbean ◽  
Tumour Cell Lines ◽  
New Compounds ◽  
Ir Spectroscopic ◽  
Human Tumour Cell Lines ◽  
Spongian Diterpene

Two new spongian furanoditerpenes, 3β-hydroxyspongia-13(16),14-dien-2-one (1) and 19-dehydroxy-spongian diterpene 17 (2), along with five known terpenes, the spongian furanoditerpenes 9-nor-3-hydroxyspongia-3,13(16),14-trien-2-one (3), 3β,19 dihydroxyspongia-13(16),14-dien-2-one (epispongiadiol) (4) and spongian diterpene 17 (5), the furanoditerpene ambliol C (6), and the sesterterpene scalarin (7), were isolated from the methanolic extract of the sponge Spongia tubulifera, collected in the Mexican Caribbean. The planar structures of the new compounds were elucidated by 1D/2D NMR and IR spectroscopic analysis, high resolution electrospray mass spectrometry (HRESIMS), and comparison of their spectral data with those reported in the literature. Absolute configurations were determined by comparison of the experimental electronic circular dichroism (ECD) spectrum with those calculated by time-dependent density functional theory (TDDFT). Compounds 1, 4, and 6 displayed weak cytotoxic activity against different human tumour cell lines.

Two new spongian diterpene derivatives from the aquaculture sponge Spongia officinalis Linnaeus, 1759

2021 ◽  
pp. 1-11
Author(s):  
Tianyun Jin ◽  
Pinglin Li ◽  
Cili Wang ◽  
Xuli Tang ◽  
Xiaoli Yv ◽  
...  
Keyword(s):  
Spongian Diterpene ◽  
Spongia Officinalis

scholarly journals Chromolactol, an Oxygenated Diterpene from the Indo-Pacific Nudibranch Goniobranchus coi: Spectroscopic and Computational Studies

2018 ◽  
Vol 71 (10) ◽  
pp. 798 ◽  
Author(s):  
Ariyanti S. Dewi ◽  
Gregory K. Pierens ◽  
Karen L. Cheney ◽  
Joanne T. Blanchfield ◽  
Mary J. Garson
Keyword(s):  
Molecular Modelling ◽  
Density Functional Calculations ◽  
Density Functional ◽  
Biosynthetic Pathway ◽  
Computational Studies ◽  
Relative Configuration ◽  
Data Comparison ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
Spongian Diterpene

A rearranged spongian diterpene chromolactol was obtained from the mantle extract of the Indo-Pacific nudibranch Goniobranchus coi. The structure of chromolactol, either 1a or 1b, which was investigated by extensive NMR experiments and by data comparison as well as by molecular modelling studies and density functional calculations, has a different relative configuration of the 2,8-dioxabicyclo-[3.3.0]-octane ring compared with the co-metabolite norrisolide (2). A biosynthetic pathway leading to the preferred diastereomer of chromolactol (1a) is presented.

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