Antibiotic Structure and Biosynthesis

1986 ◽  
Vol 49 (1) ◽  
pp. 35-47 ◽  
Author(s):  
John W. Westley
Keyword(s):  
Antibiotic Structure

Unified stereochemical model of polyether antibiotic structure and biogenesis

1983 ◽  
Vol 105 (11) ◽  
pp. 3594-3600 ◽  
Author(s):  
David E. Cane ◽  
Walter D. Celmer ◽  
John W. Westley
Keyword(s):  
Antibiotic Structure

Antibiotic glycosyltransferases

2003 ◽  
Vol 31 (3) ◽  
pp. 487-492 ◽  
Author(s):  
C.T. Walsh ◽  
H.C. Losey ◽  
C.L. Freel Meyers
Keyword(s):  
Dna Gyrase ◽  
Glycopeptide Antibiotics ◽  
Initial Characterization ◽  
Antibiotic Structure

In the biosynthesis of several classes of antibiotics, sugars are attached to aglycone scaffolds by antibiotic-specific glycosyltransferases in the latter stages of the pathways. Two glycosylation pathways will be examined: the glycopeptide antibiotics of the vancomycin class and the aminocoumarin antibiotics of the novobiocin class. An oxidatively cross-linked heptapeptide scaffold is sequentially glucosylated and vancosaminylated by GtfE and GtfD, respectively, in vancomycin maturation, while in chloroeremomycin assembly the same heptapeptide is glucosylated by GtfB, then epivancosaminylated at two distinct sites by GtfA and GtfC. The specificity and mechanism of these glycosyltransferases will be discussed. In novobiocin biosynthesis, three enzymes (NovM, NovP and NovN) are thought to act sequentially to transfer an l-noviose moiety to the novobiocic acid aglycone (NovM), followed by 4´-hydroxyl methylation (NovP) and 3´-hydroxyl carbamoylation to produce the mature antibiotic structure, targeting the GyrB subunit of DNA gyrase. Initial characterization of NovM and NovP will be discussed.

ChemInform Abstract: Kedarcidin, a New Chromoprotein Antitumor Antibiotic: Structure Elucidation of Kedarcidin Chromophore.

ChemInform ◽  
2010 ◽  
Vol 24 (3) ◽  
pp. no-no
Author(s):  
J. E. LEET ◽  
D. R. SCHROEDER ◽  
S. J. HOFSTEAD ◽  
J. GOLIK ◽  
K. L. COLSON ◽  
...  
Keyword(s):  
Structure Elucidation ◽  
Antitumor Antibiotic ◽  
Antibiotic Structure

Macrolide antibiotic structure determination by fast atom bombardment/ tandem mas, spectrometry

Tetrahedron ◽  
1993 ◽  
Vol 49 (41) ◽  
pp. 9221-9234 ◽  
Author(s):  
Y. Shida ◽  
L.J. Deterding ◽  
K. O'Hara ◽  
M. Kono ◽  
K.B. Tamer
Keyword(s):  
Structure Determination ◽  
Fast Atom Bombardment ◽  
Macrolide Antibiotic ◽  
Antibiotic Structure

scholarly journals On the perfect diameter condition to optimize the antibiotic nanoencapsulation: case of gramicidin

2019 ◽  
Vol 8 (3) ◽  
pp. 654-660 ◽  
Keyword(s):  
Molecular Dynamics ◽  
Free Energy ◽  
Ionic Transport ◽  
Transport Mechanisms ◽  
Ion Diffusion ◽  
Energy Profiles ◽  
The Stability ◽  
Dynamics Simulations ◽  
Antibiotic Structure ◽  
Free Energy Profiles

In the present work, we propose to investigate the ionic transport mechanisms in a new optimized biomimetic system. Our studies performed using classical molecular dynamics simulations show that it was possible to optimize the geometry of a hydrophobic nanopore in order to stabilize a small antibiotic by confinement. The analyses of the antibiotic structure gathered with the free energy profiles of ion diffusion through the channel of the antibiotic demonstrate the stability and the functional encapsulation of the drug. It opens a new way to build biomimetic nanochannel or nanovector for drug delivery.

scholarly journals PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity.

1986 ◽  
Vol 39 (6) ◽  
pp. 800-803 ◽  
Author(s):  
T. A. SMITKA ◽  
R. H. BUNGE ◽  
J. H. WILTON ◽  
G. C. HOKANSON ◽  
J. C. FRENCH ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Antitumor Antibiotic ◽  
Antibiotic Structure
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