scholarly journals Withaferin A, a Steroidal Lactone from Withania somnifera, Induces Mitotic Catastrophe and Growth Arrest in Prostate Cancer Cells

2013 ◽  
Vol 76 (10) ◽  
pp. 1909-1915 ◽  
Author(s):  
Ram V. Roy ◽  
Suman Suman ◽  
Trinath P. Das ◽  
Joe E. Luevano ◽  
Chendil Damodaran
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Withania Somnifera ◽  
Growth Arrest ◽  
Withaferin A ◽  
Mitotic Catastrophe ◽  
Prostate Cancer Cells ◽  
Steroidal Lactone

scholarly journals Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e15288 ◽  
Author(s):  
Qinghe Chen ◽  
Suthakar Ganapathy ◽  
Karan P. Singh ◽  
Sharmila Shankar ◽  
Rakesh K. Srivastava
Keyword(s):  
Prostate Cancer ◽  
Transcription Factors ◽  
Cancer Cells ◽  
Growth Arrest ◽  
Prostate Cancer Cells ◽  
Foxo Transcription Factors

scholarly journals Novel Thienopyrimidine Derivative, RP-010, Induces β-Catenin Fragmentation and Is Efficacious against Prostate Cancer Cells

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 711 ◽  
Author(s):  
Haneen Amawi ◽  
Noor Hussein ◽  
Sai H. S. Boddu ◽  
Chandrabose Karthikeyan ◽  
Frederick E. Williams ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Nuclear Translocation ◽  
Wide Spectrum ◽  
Thiophene Ring ◽  
Mitotic Catastrophe ◽  
Prostate Cancer Cells

Thienopyrimidines containing a thiophene ring fused to pyrimidine are reported to have a wide-spectrum of anticancer efficacy in vitro. Here, we report for the first time that thieno[3,2-d]pyrimidine-based compounds, also known as the RP series, have efficacy in prostate cancer cells. The compound RP-010 was efficacious against both PC-3 and DU145 prostate cancer (PC) cells (IC50 < 1 µM). The cytotoxicity of RP-010 was significantly lower in non-PC, CHO, and CRL-1459 cell lines. RP-010 (0.5, 1, 2, and 4 µM) arrested prostate cancer cells in G2 phase of the cell cycle, and induced mitotic catastrophe and apoptosis in both PC cell lines. Mechanistic studies suggested that RP-010 (1 and 2 µM) affected the wingless-type MMTV (Wnt)/β-catenin signaling pathway, in association with β-catenin fragmentation, while also downregulating important proteins in the pathway, including LRP-6, DVL3, and c-Myc. Interestingly, RP-010 (1 and 2 µM) induced nuclear translocation of the negative feedback proteins, Naked 1 and Naked 2, in the Wnt pathway. In addition, RP-010 (0.5, 1, 2 and 4 µM) significantly decreased the migration of PC cells in vitro. Finally, RP-010 did not produce significant toxic effects in zebrafish at concentrations of up to 6 µM. In conclusion, RP-010 may be an efficacious and relatively nontoxic anticancer compound for prostate cancer. Future mechanistic and in vivo efficacy studies are needed to optimize the hit compound RP-010 for lead optimization and clinical use.

Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells

2008 ◽  
Vol 217 (2) ◽  
pp. 494-501 ◽  
Author(s):  
Francesco Fabbri ◽  
Dino Amadori ◽  
Silvia Carloni ◽  
Giovanni Brigliadori ◽  
Anna Tesei ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Mitotic Catastrophe ◽  
Hormone Refractory Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Hormone Refractory

scholarly journals Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134137 ◽  
Author(s):  
Yukihiro Nishikawa ◽  
Daisuke Okuzaki ◽  
Kohshiro Fukushima ◽  
Satomi Mukai ◽  
Shouichi Ohno ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Withaferin A ◽  
Normal Fibroblast ◽  
Fibroblast Cells ◽  
Prostate Cancer Cells ◽  
Androgen Independent
Sign in / Sign up

Export Citation Format

Share Document