Scopoletin and Scopolin Isolated from Artemisia iwayomogi Suppress Differentiation of Osteoclastic Macrophage RAW 264.7 Cells by Scavenging Reactive Oxygen Species

2013 ◽  
Vol 76 (4) ◽  
pp. 615-620 ◽  
Author(s):  
Sang-Hyun Lee ◽  
Yan Ding ◽  
Xi Tao Yan ◽  
Young-Ho Kim ◽  
Hae-Dong Jang
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Oxygen Species ◽  
Artemisia Iwayomogi

Danshensu Attenuates Hypoxia-Induced Reactive Oxygen Species Production and Inducible Nitric Oxide Synthase Expression in RAW 264.7 Cells

2019 ◽  
Vol 18 (1) ◽  
pp. 89-95
Author(s):  
Lin Chih-Hung ◽  
Lan Chou-Chin ◽  
Chiu Valeria ◽  
Hsieh Po-Chun ◽  
Kuo Chan-Yen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Oxygen Species ◽  
Species Production ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Danshensu, isolated from Salvia miltiorrhiza (Danshen), is known to have anti-inflammatory properties. Therefore danshen is extensively used in many nutraceutical formulations. Reactive oxygen species are essential for the development of hypoxia-induced inflammation. Generation of reactive oxygen species by infiltrating macrophages is common in various diseases such as cardiovascular disease, neurodegenerative disease, tumor, and aging. To explore the mechanism underlying the attenuation of inflammation, we used RAW 264.7 cells as a model and hypoxia as an inducer of inflammation. The results showed the protective mechanism of danshensu on reactive oxygen species production, hypoxia-inducible factor 1-alpha expression, c-Jun N-terminal kinase phosphorylation, nuclear translocation of nuclear factor kappa B, and inducible nitric oxide synthase expression following hypoxia in RAW 264.7 cells.

IL-1β induces MMP-9 via reactive oxygen species and NF-κB in murine macrophage RAW 264.7 cells

2002 ◽  
Vol 298 (2) ◽  
pp. 251-256 ◽  
Author(s):  
Hyeon G Yoo ◽  
Boo.A Shin ◽  
Jung S Park ◽  
Kee H Lee ◽  
Kee O Chay ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Oxygen Species ◽  
Murine Macrophage

scholarly journals Reactive oxygen species are the major antibacterials against Salmonella Typhimurium purine auxotrophs in the phagosome of RAW 264.7 cells

2008 ◽  
Vol 10 (5) ◽  
pp. 1058-1073 ◽  
Author(s):  
Radha K. R. Mantena ◽  
Odilia L. C. Wijburg ◽  
Christofer Vindurampulle ◽  
Vicki R. Bennett-Wood ◽  
Anna Walduck ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Salmonella Typhimurium ◽  
Reactive Oxygen ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Oxygen Species
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