Caffeic Acid Phenethyl Ester Inhibits PDGF-Induced Proliferation of Vascular Smooth Muscle Cells via Activation of p38 MAPK, HIF-1α, and Heme Oxygenase-1

2011 ◽  
Vol 74 (3) ◽  
pp. 352-356 ◽  
Author(s):  
Thomas U. Roos ◽  
Elke H. Heiss ◽  
Andrea V. Schwaiberger ◽  
Daniel Schachner ◽  
Irene M. Sroka ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Caffeic Acid ◽  
P38 Mapk ◽  
Vascular Smooth Muscle Cells ◽  
Heme Oxygenase ◽  
Muscle Cells ◽  
Caffeic Acid Phenethyl Ester ◽  
Heme Oxygenase 1

scholarly journals Epigallocatechin Gallate Attenuates Proliferation and Oxidative Stress in Human Vascular Smooth Muscle Cells Induced by Interleukin-1βvia Heme Oxygenase-1

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Po-Len Liu ◽  
Jung-Tung Liu ◽  
Hsuan-Fu Kuo ◽  
Inn-Wen Chong ◽  
Chong-Chao Hsieh
Keyword(s):  
Oxidative Stress ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Green Tea ◽  
Vascular Smooth Muscle Cells ◽  
Heme Oxygenase ◽  
Muscle Cells ◽  
Heme Oxygenase 1 ◽  
And Oxidative Stress

Proliferation of vascular smooth muscle cells (VSMCs) triggered by inflammatory stimuli and oxidative stress contributes importantly to atherogenesis. The association of green tea consumption with cardiovascular protection has been well documented in epidemiological observations, however, the underlying mechanisms remain unclear. This study aimed to elucidate the effects of the most active green tea catechin derivative, (−)-epigallocatechin-3-gallate (EGCG), in human aortic smooth muscle cells (HASMCs), focusing particularly on the role of a potent anti-inflammatory and antioxidative enzyme heme oxygenase-1 (HO-1). We found that pretreatment of EGCG dose- and time-dependently induced HO-1 protein levels in HASMCs. EGCG inhibited interleukin- (IL-)1β-induced HASMC proliferation and oxidative stress in a dose-dependent manner. The HO-1 inducer CoPPIX decreased IL-1β-induced cell proliferation, whereas the HO-1 enzyme inhibitor ZnPPIX significantly reversed EGCG-caused growth inhibition in IL-1β-treated HASMCs. At the molecular level, EGCG treatment significantly activated nuclear factor erythroid-2-related factor (Nrf2) transcription activities. These results suggest that EGCG might serve as a complementary and alternative medicine in the treatment of these pathologies by inducing HO-1 expression and subsequently decreasing VSMC proliferation.

Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells

2013 ◽  
Vol 230 (2) ◽  
pp. 406-413 ◽  
Author(s):  
Gabriel Stulnig ◽  
Marie-Therese Frisch ◽  
Slaven Crnkovic ◽  
Philipp Stiegler ◽  
Michael Sereinigg ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Docosahexaenoic Acid ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Heme Oxygenase ◽  
Muscle Cells ◽  
Heme Oxygenase 1 ◽  
Cytotoxic Effects

scholarly journals Neferine inhibits angiotensin II-stimulated proliferation in vascular smooth muscle cells through heme oxygenase-1

2010 ◽  
Vol 31 (6) ◽  
pp. 679-686 ◽  
Author(s):  
Xiao-chun Li ◽  
Guo-xin Tong ◽  
Yu Zhang ◽  
Shan-xin Liu ◽  
Qi-hui Jin ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Heme Oxygenase ◽  
Muscle Cells ◽  
Heme Oxygenase 1
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