Cytotoxic Furostanol Saponins and a Megastigmane Glucoside fromTribulusparvispinus

2005 ◽  
Vol 68 (10) ◽  
pp. 1549-1553 ◽  
Author(s):  
Angela Perrone ◽  
Alberto Plaza ◽  
Elena Bloise ◽  
Patrizia Nigro ◽  
Arafa I. Hamed ◽  
...  
Keyword(s):  
Furostanol Saponins ◽  
Megastigmane Glucoside

New furostanol saponins from Smilax aspera L. and their in vitro cytotoxicity

Fitoterapia ◽  
2011 ◽  
Vol 82 (2) ◽  
pp. 282-287 ◽  
Author(s):  
Antoaneta Ivanova ◽  
Bozhanka Mikhova ◽  
Tsvetelina Batsalova ◽  
Balik Dzhambazov ◽  
Ivanka Kostova
Keyword(s):  
In Vitro Cytotoxicity ◽  
Furostanol Saponins

scholarly journals Three New Furostanol Saponins from the Bulbs of Ipheion uniflorum.

1994 ◽  
Vol 42 (5) ◽  
pp. 1116-1122 ◽  
Author(s):  
Osamu NAKAMURA ◽  
Yoshihiro MIMAKI ◽  
Yutaka SASHIDA ◽  
Tamotsu NIKAIDO ◽  
Taichi OHMOTO
Keyword(s):  
Furostanol Saponins

scholarly journals Effect of Furostanol Saponins from Allium Macrostemon Bunge Bulbs on Platelet Aggregation Rate and PI3K/Akt Pathway in the Rat Model of Coronary Heart Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Hui Feng ◽  
Zhipeng Wang ◽  
Changsong Wang ◽  
Xinyi Zhu ◽  
Zhigang Liu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Platelet Aggregation ◽  
Akt Phosphorylation ◽  
Aggregation Rate ◽  
Furostanol Saponins ◽  
Sd Rats ◽  
Allium Macrostemon

Aim. To investigate the effect of Furostanol Saponins from Allium Macrostemon Bunge Bulbs (FSAMB) on platelet aggregation rate of rats with coronary heart disease and discuss the mechanism of FSAMB affecting the platelet aggregation rate through PI3K/Akt pathway. We established the rat models with coronary heart disease (CHD) and prepared the platelet-rich plasma. The effect of different concentrations of FSAMB on platelet aggregation in SD rats induced by ADP was observed in vitro and in vivo. And Lactate Dehydrogenase (LDH), Creatine Kinase-MB Form (CK-MB), and Cardiac Troponin I (cTnI) are detected in the blood to know the level of damage to heart cells. The expansion of platelets in the immobilized fibrinogen in different concentrations of FSAMB was observed. Western blot was conducted to detect the phosphorylation level of protein kinase B (also known as Akt) and the expression level of phosphoinositide 3-kinase (PI3K). We found that FSAMB had a significant inhibitory effect on the ADP-induced platelet aggregation in vitro. Intragastric administration of FSAMB also inhibited platelet aggregation induced by ADP in rats. LDH, CK-MB, and cTnI levels in serum of rats in FSAMB (672 mg/kg) group were lower than those in the model control group after the intervention (P<0.01 or P<0.05). FSAMB inhibited the expansion of platelets on immobilized fibrinogen. Also, FSAMB inhibited ADP-induced platelet PI3K expression and Akt phosphorylation. The inhibition of Akt phosphorylation by FSAMB was more obvious after the inhibition of the expression of PI3K. This study demonstrated that FSAMB can reduce the degree of myocardial cell damage and inhibit ADP-induced platelet aggregation in SD rats, possibly by inhibiting platelet PI3K/Akt signaling pathway in vitro and in vivo.

Furostanol saponins and quercetin glycosides from the leaves of Helleborus viridis L.

2004 ◽  
Vol 65 (21) ◽  
pp. 2921-2928 ◽  
Author(s):  
Alessandra Braca ◽  
Josè Maria Prieto ◽  
Nunziatina De Tommasi ◽  
Franca Tomè ◽  
Ivano Morelli
Keyword(s):  
Furostanol Saponins ◽  
Quercetin Glycosides

Furostanol saponins and ecdysones with cytotoxic activity fromHelleborus bocconeissp.intermedius

2009 ◽  
Vol 23 (9) ◽  
pp. 1243-1249 ◽  
Author(s):  
Sergio Rosselli ◽  
Antonella Maggio ◽  
Maurizio Bruno ◽  
Vivienne Spadaro ◽  
Carmen Formisano ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Furostanol Saponins

Two novel furostanol saponins from the tubers ofOphiopogon japonicus

2013 ◽  
Vol 15 (5) ◽  
pp. 459-465 ◽  
Author(s):  
Yu Guo ◽  
Yi-Xun Liu ◽  
Li-Ping Kang ◽  
Tao Zhang ◽  
He-Shui Yu ◽  
...  
Keyword(s):  
Furostanol Saponins

Sequestration of Furostanol Saponins by Monophadnus Sawfly Larvae

2007 ◽  
Vol 33 (3) ◽  
pp. 513-524 ◽  
Author(s):  
José M. Prieto ◽  
Urs Schaffner ◽  
Alison Barker ◽  
Alessandra Braca ◽  
Tiziana Siciliano ◽  
...  
Keyword(s):  
Sawfly Larvae ◽  
Furostanol Saponins

Two novel furostanol saponins from the rhizomes of Dioscorea panthaica Prain et Burkill and their cytotoxic activity

Tetrahedron ◽  
2001 ◽  
Vol 57 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Mei Dong ◽  
Xi-zhi Feng ◽  
Ben-xiang Wang ◽  
Li-jun Wu ◽  
Takashi Ikejima
Keyword(s):  
Cytotoxic Activity ◽  
Furostanol Saponins

Furostanol saponins from Allium tuberosum

1999 ◽  
Vol 52 (8) ◽  
pp. 1611-1615 ◽  
Author(s):  
Shengmin Sang ◽  
Aina Lao ◽  
Hongcheng Wang ◽  
Zhongliang Chen
Keyword(s):  
Allium Tuberosum ◽  
Furostanol Saponins

Furostanol saponins from Chinese onion induce G2/M cell-cycle arrest and apoptosis through mitochondria-mediate pathway in HepG2 cells

Steroids ◽  
2019 ◽  
Vol 148 ◽  
pp. 11-18 ◽  
Author(s):  
Yihai Wang ◽  
Xiaomin Yi ◽  
Limin Xiang ◽  
Yuying Huang ◽  
Zhe Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Hepg2 Cells ◽  
M Cell ◽  
Furostanol Saponins ◽  
Cycle Arrest
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