Structures and Aldose Reductase Inhibitory Effects of Bromophenols from the Red AlgaSymphyocladialatiuscula

2005 ◽  
Vol 68 (4) ◽  
pp. 620-622 ◽  
Author(s):  
Wei Wang ◽  
Yoshihito Okada ◽  
Haibo Shi ◽  
Yongqi Wang ◽  
Toru Okuyama
Keyword(s):  
Aldose Reductase ◽  
Inhibitory Effects

Inhibitory effects ofGanoderma applanatum on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues

2005 ◽  
Vol 19 (6) ◽  
pp. 477-480 ◽  
Author(s):  
Sang Hoon Jung ◽  
Yeon Sil Lee ◽  
Sang Hee Shim ◽  
Sanghyun Lee ◽  
Kuk Hyun Shin ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Diabetic Rat ◽  
Rat Tissues ◽  
Inhibitory Effects ◽  
Rat Lens Aldose Reductase

scholarly journals The Inhibitory Effect ofPrunella vulgarisL. on Aldose Reductase and Protein Glycation

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Hong Mei Li ◽  
Jin Kyu Kim ◽  
Jai Man Jang ◽  
Sang Oh Kwon ◽  
Cheng Bi Cui ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Inhibitory Effect ◽  
Protein Glycation ◽  
Prunella Vulgaris ◽  
Inhibitory Effects ◽  
Advanced Glycation ◽  
High Concentration ◽  
Potent Inhibition ◽  
Glycation End Products

To evaluate the aldose reductase (AR) enzyme inhibitory ability ofPrunella vulgarisL. extract, six compounds were isolated and tested for their effects. The components were subjected toin vitrobioassays to investigate their inhibitory assays using rat lens aldose reductase (rAR) and human recombinant AR (rhAR). Among them, caffeic acid ethylene ester showed the potent inhibition, with the IC50values of rAR and rhAR at3.2±0.55 μM and12.58±0.32 μM, respectively. In the kinetic analyses using Lineweaver-Burk plots of 1/velocity and 1/concentration of substrate, this compound showed noncompetitive inhibition against rhAR. Furthermore, it inhibited galactitol formation in a rat lens incubated with a high concentration of galactose. Also it has antioxidative as well as advanced glycation end products (AGEs) inhibitory effects. As a result, this compound could be offered as a leading compound for further study as a new natural products drug for diabetic complications.

scholarly journals Inhibitory effects of Synurus excelsus and Weigela subsessilis on aldose reductase and HPLC-UV analysis of scopolin, scopoletin, and quercetin

2018 ◽  
Vol 61 (2) ◽  
pp. 135-139 ◽  
Author(s):  
Norman G. Quilantang ◽  
Ju Sung Lee ◽  
Seo Hyun Ryu ◽  
Se Hoon Park ◽  
Jae Sang Byun ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Inhibitory Effects ◽  
Weigela Subsessilis

Antioxidant activity and inhibitory effects of 2-hydroxy-3-methylcyclopent-2-enone isolated from ribose–histidine Maillard reaction products on aldose reductase and tyrosinase

2018 ◽  
Vol 9 (3) ◽  
pp. 1790-1799 ◽  
Author(s):  
Seung Hwan Hwang ◽  
Zhiqiang Wang ◽  
Hong-Won Suh ◽  
Soon Sung Lim
Keyword(s):  
Antioxidant Activity ◽  
Amino Acid ◽  
Functional Properties ◽  
Aldose Reductase ◽  
Maillard Reaction ◽  
Maillard Reaction Products ◽  
Reaction Products ◽  
Inhibitory Effects

This study aimed to better understand the functional properties of ribose and 20 amino acid Maillard reaction products (MRPs).

Structures of acylated sucroses and an acylated flavonol glycoside and inhibitory effects of constituents on aldose reductase from the flower buds of Prunus mume

2013 ◽  
Vol 67 (4) ◽  
pp. 799-806 ◽  
Author(s):  
Seikou Nakamura ◽  
Katsuyoshi Fujimoto ◽  
Takahiro Matsumoto ◽  
Tomoe Ohta ◽  
Keiko Ogawa ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Flavonol Glycoside ◽  
Prunus Mume ◽  
Inhibitory Effects ◽  
Flower Buds
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