Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials†

2004 ◽  
Vol 67 (8) ◽  
pp. 1216-1238 ◽  
Author(s):  
David J. Newman ◽  
Gordon M. Cragg
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Preclinical Trials ◽  
Related Compounds

Anticancer agent-based marine natural products and related compounds

2015 ◽  
Vol 17 (2) ◽  
pp. 199-216 ◽  
Author(s):  
Jian-Wei Chen ◽  
Qi-Hao Wu ◽  
David C. Rowley ◽  
Ammar M.Q. Al-Kareef ◽  
Hong Wang
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Anticancer Agent ◽  
Agent Based ◽  
Related Compounds

The discoipyrroles: A multifaceted approach to understand a novel family of marine natural products

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DA Colosimo ◽  
F Cai ◽  
Y Hu ◽  
MB Potts ◽  
MA White ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Multifaceted Approach

Synthesis of Marine Natural Products 1

1992 ◽  
Author(s):  
K. F. Albizati ◽  
V. A. Martin ◽  
M. R. Agharahimi ◽  
D. A. Stolze
Keyword(s):  
Natural Products ◽  
Marine Natural Products

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

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