Isolation of Cytochrome P450 Inhibitors from Strawberry Fruit,Fragaria ananassa

2004 ◽  
Vol 67 (11) ◽  
pp. 1839-1841 ◽  
Author(s):  
Sachiko Tsukamoto ◽  
Kyoko Tomise ◽  
Maki Aburatani ◽  
Hiroyuki Onuki ◽  
Hiroshi Hirorta ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Fragaria Ananassa ◽  
Strawberry Fruit ◽  
P450 Inhibitors

scholarly journals Cultivation Conditions Change Aroma Volatiles of Strawberry Fruit

Horticulturae ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 81
Author(s):  
Yunduan Li ◽  
Yuanyuan Zhang ◽  
Xincheng Liu ◽  
Yuwei Xiao ◽  
Zuying Zhang ◽  
...  
Keyword(s):  
Volatile Compounds ◽  
Major Contributor ◽  
Fragaria Ananassa ◽  
Strawberry Fruit ◽  
Cultivation Conditions ◽  
Soil Culture ◽  
Aroma Volatiles ◽  
Ms Analysis ◽  
Significant Difference ◽  
Strawberry Cultivars

Volatile compounds principally contribute to flavor of strawberry (Fragaria × ananassa) fruit. Besides to genetics, cultivation conditions play an important role in fruit volatile formation. Compared to soil culture as control, effects of substrate culture on volatile compounds of two strawberry cultivars (‘Amaou’ and ‘Yuexin’) were investigated. GC-MS analysis revealed significant difference in volatile contents of ‘Amaou’ strawberry caused by substrate culture. No significant effect was observed for cultivar ‘Yuexin’. For ‘Amaou’ strawberry from soil culture produced higher volatile contents compared with substrate culture. This difference is contributed by high contents of esters, lactones, ketones, aldehydes, terpenes, hydrocarbons, acids, furans and phenols in ‘Amaou’ strawberry fruit from soil culture. Furanones, beta-linalool, trans-Nerolidol and esters are major contributor to strawberry aroma, whose contents are higher in soil culture planted fruit when compared to substrate culture. Moreover, strawberry fruit from soil culture had higher transcripts related to volatile biosynthesis were observed, including FaQR, FaOMT, FaNES1, FaSAAT and FaAAT2.

Chemical regulation of abscisic acid catabolism in plants by cytochrome P450 inhibitors

2005 ◽  
Vol 13 (14) ◽  
pp. 4491-4498 ◽  
Author(s):  
Nobutaka Kitahata ◽  
Shigeki Saito ◽  
Yutaka Miyazawa ◽  
Taishi Umezawa ◽  
Yukihisa Shimada ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Abscisic Acid ◽  
Chemical Regulation ◽  
P450 Inhibitors

Ruthenium-containing P450 inhibitors for dual enzyme inhibition and DNA damage

2017 ◽  
Vol 46 (7) ◽  
pp. 2165-2173 ◽  
Author(s):  
Ana Zamora ◽  
Catherine A. Denning ◽  
David K. Heidary ◽  
Erin Wachter ◽  
Leona A. Nease ◽  
...  
Keyword(s):  
Dna Damage ◽  
Drug Resistance ◽  
Cytochrome P450 ◽  
Enzyme Inhibition ◽  
Metal Center ◽  
P450 Inhibitors

A light-activated prodrug delivers both a DNA damaging metal center and a cytochrome P450 inhibitor to prevent drug resistance.

Whole-cell amperometric biosensor for screening of cytochrome P450 inhibitors

2016 ◽  
Vol 223 ◽  
pp. 392-399 ◽  
Author(s):  
Tal Yoetz-Kopelman ◽  
Carmit Porat-Ophir ◽  
Yosi Shacham-Diamand ◽  
Amihay Freeman
Keyword(s):  
Cytochrome P450 ◽  
Amperometric Biosensor ◽  
Whole Cell ◽  
P450 Inhibitors

scholarly journals Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery

1996 ◽  
Vol 118 (5) ◽  
pp. 1147-1152 ◽  
Author(s):  
Peter M. Zygmunt ◽  
Gillian Edwards ◽  
Arthur H. Weston ◽  
S. Christopher Davis ◽  
Edward D. Högestätt
Keyword(s):  
Cytochrome P450 ◽  
Hepatic Artery ◽  
P450 Inhibitors

scholarly journals Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein

1996 ◽  
Vol 119 (4) ◽  
pp. 691-701 ◽  
Author(s):  
Gillian Edwards ◽  
Peter M. Zygmunt ◽  
Edward D. Högestätt ◽  
Arthur H. Weston
Keyword(s):  
Cytochrome P450 ◽  
Portal Vein ◽  
Potassium Currents ◽  
Mechanical Activity ◽  
Rat Portal Vein ◽  
P450 Inhibitors

PARTIAL CHARACTERIZATION OF CHLOROPHYLLASE FROM STRAWBERRY FRUIT (FRAGARIA ANANASSA, DUCH.)

1994 ◽  
Vol 18 (4) ◽  
pp. 213-226 ◽  
Author(s):  
GUSTAVO ADOLFO MARTINEZ ◽  
PEDRO MARCOS CIVELLO ◽  
ALICIA RAQUEL CHAVES ◽  
MARÍA CRISTINA AÑÓN
Keyword(s):  
Partial Characterization ◽  
Fragaria Ananassa ◽  
Strawberry Fruit

scholarly journals Restarting antidepressant and antipsychotic medication after intentional overdoses: need for evidence-based guidance

2019 ◽  
Vol 9 ◽  
pp. 204512531983688
Author(s):  
Emma Tay ◽  
Andreas Sotiriou ◽  
Garry G. Graham ◽  
Kay Wilhelm ◽  
Leone Snowden ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Adverse Effects ◽  
Antipsychotic Drugs ◽  
Plasma Concentrations ◽  
Pharmacokinetic Data ◽  
Psychoactive Drugs ◽  
Cytochrome P450 Enzymes ◽  
Psychoactive Medication ◽  
Drug Overdoses ◽  
P450 Inhibitors

Intentional drug overdoses with antidepressant and antipsychotic medications are an increasingly common problem. Currently, there is little guidance with regard to reintroduction of these medications after intentional overdoses. We have used published toxicological and pharmacokinetic data to obtain factors which control the recovery from overdoses. From such data, we have proposed guidance regarding their reintroduction, provided there are no adverse effects or contraindications. Tentatively, we suggest that when adverse effects from the overdose are lost, treatment could recommence after a further mean half-life of elimination. Most antidepressant and antipsychotic drugs are metabolized by cytochrome P450 enzymes and, where cytochrome P450 inhibitors are co-ingested, serial plasma concentrations should optimally be obtained in order to assess a suitable time for reintroduction of the psychoactive drugs. We hope the proposals presented will stimulate research and discussion that lead to better guidance for clinicians concerning reintroduction of psychoactive medication after intentional overdose.

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