Choosing the Best Pulse Sequences, Acquisition Parameters, Postacquisition Processing Strategies, and Probes for Natural Product Structure Elucidation by NMR Spectroscopy

2002 ◽  
Vol 65 (2) ◽  
pp. 221-244 ◽  
Author(s):  
William F. Reynolds ◽  
Raúl G. Enríquez
Keyword(s):  
Nmr Spectroscopy ◽  
Natural Product ◽  
Structure Elucidation ◽  
Pulse Sequences ◽  
Product Structure ◽  
Processing Strategies

scholarly journals The importance of asking “how and why?” in natural product structure elucidation

2017 ◽  
Vol 34 (10) ◽  
pp. 1193-1202 ◽  
Author(s):  
Patrick D. Brown ◽  
Andrew L. Lawrence
Keyword(s):  
Natural Product ◽  
Structure Elucidation ◽  
Biological Function ◽  
Product Structure ◽  
Careful Consideration

This review highlights why careful consideration of the biosynthetic origin (the how) and the biological function (the why) of a natural product can be so useful during the determination of its structure.

scholarly journals Assigning regioisomeric or diastereoisomeric relations of problematic trisubstituted double-bonds through heteronuclear 2D selective J-resolved NMR spectroscopy

RSC Advances ◽  
2015 ◽  
Vol 5 (47) ◽  
pp. 37138-37148 ◽  
Author(s):  
Marie Hoffmann ◽  
Solène Miaskiewicz ◽  
Jean-Marc Weibel ◽  
Patrick Pale ◽  
Aurélien Blanc
Keyword(s):  
Nmr Spectroscopy ◽  
Natural Product ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Double Bonds ◽  
Nmr Methods

Although one of the first 2D NMR methods, but so far neglected, selectiveJ-resolved NMR spectroscopy offers a unique opportunity to help organic chemists in structure elucidation, avoiding natural and non-natural product misassignments.

scholarly journals Sharpening Up Your Spectra: Broadband Homonuclear Decoupling in HSQC by Real-Time Pure Shift Acquisition

Synlett ◽  
2019 ◽  
Vol 30 (09) ◽  
pp. 1015-1025 ◽  
Author(s):  
Peter Kiraly ◽  
Gareth Morris ◽  
Liu Quanxiu ◽  
Mathias Nilsson
Keyword(s):  
Nmr Spectroscopy ◽  
Real Time ◽  
Structure Elucidation ◽  
Method Development ◽  
Pulse Sequences ◽  
Resolution Enhancement ◽  
Daily Routine ◽  
Two Factors ◽  
Nmr Methods ◽  
Processing Techniques

Structure elucidation using NMR spectroscopy has become a vital part of the toolkit of modern synthetic chemistry. Characterisation of final products, quality control of production, analysis of complex mixtures in synthetic method development, and structure elucidation of isolated natural products are examples where NMR spectroscopy is a part of daily routine. The two factors that usually limit the applicability of NMR are resolution and sensitivity. The experimental method described in this Account, real-time pure shift acquisition, yields heteronuclear correlation spectra such as HSQC that offer significant improvements in both resolution and sensitivity, at negligible cost to the analyst. The advantages that real-time pure shift acquisition enjoys over conventional experiments are discussed and illustrated with selected examples including carbohydrate and alkaloid mixtures. Advanced data acquisition and processing techniques that reduce experiment time and are easily combined with pure shift NMR methods are also described.1 Introduction2 Simultaneous Sensitivity and Resolution Enhancement Using Real-Time Acquisition in HSQC3 Processing Pure Shift Data4 Pulse Sequences for Real-Time Pure Shift HSQC5 Conclusions and Future Perspectives

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