Discovery of Natural Products fromCurcumalongathat Protect Cells from Beta-Amyloid Insult:  A Drug Discovery Effort against Alzheimer's Disease

2002 ◽  
Vol 65 (9) ◽  
pp. 1227-1231 ◽  
Author(s):  
So-Young Park ◽  
Darrick S. H. L. Kim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Drug Discovery ◽  
Beta Amyloid

Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes

2014 ◽  
Vol 15 ◽  
pp. 116-145 ◽  
Author(s):  
Tiago Silva ◽  
Joana Reis ◽  
José Teixeira ◽  
Fernanda Borges
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Drug Discovery

scholarly journals Pharmacological and Neuroprotective Natural Products in the Treatment of Alzheimer’s Disease

2021 ◽  
Vol 6 (3) ◽  
pp. 366-382
Author(s):  
A.Mary Prashanthi ◽  
Vissarapu Naga Lakshmi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Drug Discovery ◽  
Medical Condition ◽  
Local Area ◽  
Clinical Use ◽  
Pharmacological Agents ◽  
New Methodologies ◽  
Wide Assortment

Alzheimer's illness (AD) is a progressive, neurodegenerative issue and has become an incredible medical condition especially among the old individuals, for the most part happens after the age of 55 years and expansion in frequency with propelling age, however its therapy alternatives are generally not many and inadequate. The reason for AD isn't actually known, yet is thought to incorporate both hereditary and natural elements (multifactorial). There is no known remedy for Alzheimer's sickness, since it is beyond the realm of imagination to expect to invert the demise of synapses however the indications can be overseen by some pharmacological specialists and Neuroprotective Natural Products. In spite of the improvement of various pharmacological methodologies throughout the years pointed toward treating Alzheimer's Disease (AD) without a doubt, not many have been supported for clinical use in patients. To date there still exists no illness adjusting treatment that could forestall or protect the intellectual debilitation, especially of memory aquisition, that is normal for AD. One of the opportunities for this situation may be that most of medication disclosure endeavors centers around result proportions of diminished neuropathological biomarkers normal for AD, without taking into acount neuronal cycles fundamental for the age and support of memory measures. In endeavors to find new methodologies for AD treatment, regular items have stirred interest in the examination local area and in the drug business for their neuroprotective movement, focusing on various obsessive instruments related with AD. A wide assortment of normal items from various beginnings have been assessed preclinically and clinically for their neuroprotective instruments in forestalling and lessening the multifactorial pathologies of AD. It is accepted that normal item blends or concentrates containing different bioactive mixtures that can work additively or synergistically to display various neuroprotective systems may be a compelling methodology in AD drug discovery. Keywords: Alzheimer’s disease (AD); neurodegenerative disease, natural products, pharmacological agents.

Natural Anti-inflammatory compounds as Drug candidates in Alzheimer’s disease

2020 ◽  
Vol 27 ◽  
Author(s):  
Reyaz Hassan Mir ◽  
Abdul Jalil Shah ◽  
Roohi Mohi-ud-din ◽  
Faheem Hyder Potoo ◽  
Mohd. Akbar Dar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Protective Action ◽  
New Drugs ◽  
Huperzine A ◽  
Brain Disorder ◽  
Anti Inflammatory

: Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by memory impairment, dementia, oxidative stress in elderly people. Currently, only a few drugs are available in the market with various adverse effects. So to develop new drugs with protective action against the disease, research is turning to the identification of plant products as a remedy. Natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Phytochemicals including Curcumin, Resveratrol, Quercetin, Huperzine-A, Rosmarinic acid, genistein, obovatol, and Oxyresvertarol were reported molecules for the treatment of AD. Several alkaloids such as galantamine, oridonin, glaucocalyxin B, tetrandrine, berberine, anatabine have been shown anti-inflammatory effects in AD models in vitro as well as in-vivo. In conclusion, natural products from plants represent interesting candidates for the treatment of AD. This review highlights the potential of specific compounds from natural products along with their synthetic derivatives to counteract AD in the CNS.

An Insight in Pathophysiological Mechanism of Alzheimer’s Disease and its Management using Plant Natural Products

2020 ◽  
Vol 20 ◽  
Author(s):  
Zeba Firdaus ◽  
Tryambak Deo Singh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Side Effects ◽  
Neuronal Degeneration ◽  
Acetylcholinesterase Inhibitor ◽  
Pathophysiological Mechanism ◽  
Limited Effectiveness ◽  
Drug Development Research ◽  
Sites Of Action

: Alzheimer’s disease (AD) is an age-associated nervous system disorder and a leading cause of dementia worldwide. Clinically it is described by cognitive impairment, and pathophysiologically by deposition of amyloid plaques and neurofibrillary tangles in the brain and neurodegeneration. This article reviews the pathophysiology, course of neuronal degeneration, and the various possible hypothesis of AD progression. These hypotheses include amyloid cascade, tau hyperphosphorylation, cholinergic disruption, metal dysregulation, vascular dysfunction, oxidative stress, and neuroinflammation. There is an exponential increase in the occurrence of the AD in recent few years that indicate an urgent need to develop some effective treatment. Currently, only 2 classes of drugs are available for AD treatment namely acetylcholinesterase inhibitor and NMDA receptor antagonist. Since AD is a complex neurological disorder and these drugs use a single target approach, alternatives are needed due to limited effectiveness and unpleasant side-effects of these drugs. Currently, plants have been used for drug development research especially because of their multiple sites of action and fewer side effects. Uses of some herbs and phytoconstituents for the management of neuronal disorders like AD have been documented in this article. Phytochemical screening of these plants shows the presence of many beneficial constituents like flavonoids, triterpenes, alkaloids, sterols, polyphenols, and tannins. These compounds show a wide array of pharmacological activities such as anti-amyloidogenic, anticholinesterase, and antioxidant. This article summarizes the present understanding of AD progression and gathers biochemical evidence from various works on natural products that can be useful in the management of this disease.

scholarly journals Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lishu Duan ◽  
Mufeng Hu ◽  
Joseph A. Tamm ◽  
Yelena Y. Grinberg ◽  
Fang Shen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Disease Model ◽  
Mitochondrial Morphology ◽  
Individual Gene ◽  
Human Genes ◽  
Future Drug ◽  
Tau Aggregation

AbstractAlzheimer’s disease (AD) is a common neurodegenerative disease with poor prognosis. New options for drug discovery targets are needed. We developed an imaging based arrayed CRISPR method to interrogate the human genome for modulation of in vitro correlates of AD features, and used this to assess 1525 human genes related to tau aggregation, autophagy and mitochondria. This work revealed (I) a network of tau aggregation modulators including the NF-κB pathway and inflammatory signaling, (II) a correlation between mitochondrial morphology, respiratory function and transcriptomics, (III) machine learning predicted novel roles of genes and pathways in autophagic processes and (IV) individual gene function inferences and interactions among biological processes via multi-feature clustering. These studies provide a platform to interrogate underexplored aspects of AD biology and offer several specific hypotheses for future drug discovery efforts.

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