scholarly journals In Vivo Biodistribution and Clearance Studies Using Multimodal Organically Modified Silica Nanoparticles

ACS Nano ◽  
2010 ◽  
Vol 4 (2) ◽  
pp. 699-708 ◽  
Author(s):  
Rajiv Kumar ◽  
Indrajit Roy ◽  
Tymish Y. Ohulchanskky ◽  
Lisa A. Vathy ◽  
Earl J. Bergey ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Modified Silica ◽  
In Vivo Biodistribution ◽  
Organically Modified ◽  
Clearance Studies ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles

scholarly journals Organically Modified Silica Nanoparticles Are Biocompatible and Can Be Targeted to Neurons In Vivo

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29424 ◽  
Author(s):  
Farda Barandeh ◽  
Phuong-Lan Nguyen ◽  
Rajiv Kumar ◽  
Gary J. Iacobucci ◽  
Michelle L. Kuznicki ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles

Folic acid-conjugated organically modified silica nanoparticles for enhanced targeted delivery in cancer cells and tumor in vivo

2015 ◽  
Vol 3 (29) ◽  
pp. 6081-6093 ◽  
Author(s):  
Feng Yin ◽  
Butian Zhang ◽  
Shuwen Zeng ◽  
Guimiao Lin ◽  
Jinglin Tian ◽  
...  
Keyword(s):  
Folic Acid ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
High Selectivity ◽  
Tumor Imaging ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles

Folic acid-conjugated fluorescent silica nanoparticles with biocompatibility and high-selectivity show great potential forin vivotumor imaging.

Organically modified silica nanoparticles as drug delivery vehicles in photodynamic therapy

2011 ◽  
Vol 15 (05n06) ◽  
pp. 401-411 ◽  
Author(s):  
Anurag Gupta ◽  
Lalit N. Goswami ◽  
Manivannan Ethirajan ◽  
Joseph Missert ◽  
K.V.R. Rao ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Encapsulation Efficiency ◽  
Release Kinetics ◽  
Alkyl Ether ◽  
Modified Silica ◽  
Drug Delivery Vehicles ◽  
Organically Modified ◽  
Delivery Vehicles ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles

To investigate the effect of hydrophobicity, charge and size of photosensitizers (PS) on their encapsulation efficiency in organically modified silica nanoparticles (ORMOSIL), a series of alkyl ether analogs of 2-(1′-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) containing varied number of carbon units, HPPH with anionic and cationic functionalities, and HPPH analogs with molecular weight ranging from ~630 to 6000 Daltons were synthesized. Our preliminary results suggest that these factors play a significant role in encapsulation of the photosensitizers and their release from ORMOSIL nanoparticles. The synthesis and characterization of PS-encapsulated ORMOSIL and a comparative study on the effect of PS size, lipophilicity and charge on encapsulation efficiency, photophysical characteristics and release kinetics are discussed.

Covalently Dye-Linked, Surface-Controlled, and Bioconjugated Organically Modified Silica Nanoparticles as Targeted Probes for Optical Imaging

ACS Nano ◽  
2008 ◽  
Vol 2 (3) ◽  
pp. 449-456 ◽  
Author(s):  
Rajiv Kumar ◽  
Indrajit Roy ◽  
Tymish Y. Ohulchanskyy ◽  
Lalit N. Goswami ◽  
Adela C. Bonoiu ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Silica Nanoparticles ◽  
Modified Silica ◽  
Organically Modified ◽  
Organically Modified Silica ◽  
Modified Silica Nanoparticles
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